... GC axons, which presumably contribute to the planar dendrite arborization in vivo . We show that βIII spectrin, a causal protein for spinocerebellar ataxia type 5, is required for the biased growth of dendrites. βIII spectrin deficiency causes actin mislocalization and excessive microtubule invasion...

...Jörn Hülsmeier; Jan Pielage; Christof Rickert; Gerd M. Technau; Christian Klämbt; Tobias Stork Cell-shape changes during development require a precise coupling of the cytoskeleton with proteins situated in the plasma membrane. Important elements controlling the shape of cells are the Spectrin...

...David S. Garbe; Amlan Das; Ronald R. Dubreuil; Greg J. Bashaw α- and β-Spectrin are major components of a submembrane cytoskeletal network connecting actin filaments to integral plasma membrane proteins. Besides its structural role in red blood cells, the Spectrin network is thought to function...

... actin organization in the epidermis. Loss of function in the spectrin SMA-1 partly bypasses the requirement for VAB-19 in elongation, suggesting that VAB-19 and SMA-1/spectrin might play antagonistic roles in regulation of the actin cytoskeleton. We thank J. Lewis for isolating e1036 , S. George...

... in the hypoblast layer and subsequently 200-250 positive cells were found anteriorly in the germinal crescent due to morphogenetic movement. Furthermore, in the oocytes, CVH protein was predominantly localized in granulofibrillar structures surrounding the mitochondrial cloud and spectrin protein- enriched...

...Graham H. Thomas; Daniela C. Zarnescu; Amy E. Juedes; Mark A. Bales; Amy Londergan; Carol C. Korte; Daniel P. Kiehart ABSTRACT The spectrin membrane skeleton is a ubiquitous cytoskeletal structure with several cellular roles, including the maintenance of cell integrity, determination of cell shape...

... isolated vary in phenotypic severity, with the most severe alleles showing the greatest decrease in elongation rate. The sma-1 gene encodes a homolog of β H -spectrin, a novel β-spectrin isoform first identified in Drosophila. sma-1 RNA is expressed in epithelial tissues in the C. elegans embryo...

...John K. Lee; Eric Brandin; Daniel Branton; Lawrence S. B. Goldstein ABSTRACT To understand the role of the spectrin-based membrane skeleton in generating epithelial polarity, we characterized the distribution of membrane skeletal components in Drosophila ovarian follicle cells and in somatic clones...

...Margaret de Cuevas; John K. Lee; Allan C. Spradling ABSTRACT During Drosophila oogenesis, developing germline cysts are spanned by a large cytoplasmic structure called a fusome, containing α-spectrin and the adducin-like product of the hu-li tai shao (hts) gene. We found that fusomes contain two...

.... By necessity, if such a contractile system is to exert a force, these filaments must be anchored in some way to the cell membrane. In this study, the presence of the actin-binding protein, spectrin (fodrin), is demonstrated in the neurectoderm of neurulating mouse embryos using antispectrin antibodies...