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Keywords: Smoothened
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Journal Articles
Journal: Development
Development (2021) 148 (19): dev199867.
Published: 04 October 2021
... degradation of the Hh transducer Smoothened (SMO). Deficiency of the MMM component MOSMO results in elevated SMO and increased Hh signaling, causing multiple birth defects. In utero exposure to a teratogen that directly inhibits SMO reduces the penetrance and expressivity of birth defects in Mosmo −/− embryos...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (10): dev166892.
Published: 15 May 2019
... by patched on target cells, transduced across the cell membrane by smoothened, and transmitted to the nucleus by GLI proteins to influence gene-expression programs. PKA activity can be increased or decreased by a signaling cascade initiated by GPCRs ( Fig. 5 ). When GPCRs are activated by ligands...
Journal Articles
Journal: Development
Development (2018) 145 (24): dev166850.
Published: 12 December 2018
...Cecile Giordano; Laurent Ruel; Candice Poux; Pascal Therond ABSTRACT Hedgehog (Hh) is a conserved morphogen that controls cell differentiation and tissue patterning in metazoans. In Drosophila , the Hh signal is transduced from the G protein-coupled receptor Smoothened (Smo) to the cytoplasmic Hh...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (17): 3134–3144.
Published: 01 September 2017
... to adjacent cells of the anterior compartment. We monitored Hh:GFP after pulsed expression, and analyzed the movement and colocalization of Hh, Patched (Ptc) and Smoothened (Smo) proteins tagged with GFP or mCherry and expressed at physiological levels from bacterial artificial chromosome transgenes. Hh:GFP...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (10): 1841–1850.
Published: 15 May 2017
...Matthieu Sanial; Isabelle Bécam; Line Hofmann; Julien Behague; Camilla Argüelles; Vanessa Gourhand; Lucia Bruzzone; Robert A. Holmgren; Anne Plessis Smoothened (SMO) is a G-protein-coupled receptor-related protein required for the transduction of Hedgehog (HH). The HH gradient leads to graded...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (7): 1317–1327.
Published: 01 April 2017
... and branching, but did not phenocopy transgenic expression of activated smoothened ( SmoM2 ). The epithelium showed no evidence of canonical hedgehog signaling, and hyperproliferation was not blocked by smoothened (SMO) inhibition, suggesting a non-canonical function of PTCH1. Consistent with this possibility...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (21): 4027–4037.
Published: 01 November 2016
... pp patterning and organ development. We used tissue-specific Cre driver strains to selectively delete or ectopically activate SHH signaling in NC mesenchyme or pharyngeal endoderm by expression or activity of the SHH signaling transducer smoothened ( Smo ). Loss of SHH signaling to NC mesenchyme did...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (3): 612–621.
Published: 01 February 2012
... Smoothened (Smo), a member of the G-protein-coupled receptor (GPCR) superfamily. The extracellular (EC) loops of canonical GPCRs harbor cysteine residues that engage in disulfide bonds, affecting active and inactive signaling states through regulating receptor conformation, dimerization and/or ligand binding...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (1): 85–94.
Published: 01 January 2012
...Shuofei Cheng; Dominic Maier; David R. Hipfner G-protein-coupled receptor kinases (GRKs) play a conserved role in Hedgehog (Hh) signaling. In several systems, GRKs are required for efficient Hh target gene expression. Their principal target appears to be Smoothened (Smo), the intracellular signal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (23): 5121–5134.
Published: 01 December 2011
...Samantha England; Manuel F. Batista; John K. Mich; James K. Chen; Katharine E. Lewis In mouse, Hedgehog (Hh) signalling is required for most ventral spinal neurons to form. Here, we analyse the spinal cord phenotype of zebrafish maternal-zygotic smoothened ( MZsmo ) mutants that completely lack Hh...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (8): 1263–1273.
Published: 15 April 2010
... of a patched homolog, At-ptc , that encodes a putative negative regulator of Hedgehog (Hh) signaling, prevented initiation of the symmetry-breaking cell migration. Knockdown of a smoothened homolog, At-smo , showed that Hh signaling inactivation also arrested the cells at the germ disc center, whereas moderate...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (24): 4111–4121.
Published: 15 December 2009
...) represses Smoothened (Smo) signaling by an unknown catalytic mechanism that correlates with reduced Smo levels on the basolateral membrane. Ptc contains a sterol-sensing domain and is similar to the Niemann-Pick type C-1 protein, suggesting that Ptc might regulate lipid trafficking to repress Smo. However...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (22): 3789–3799.
Published: 15 November 2008
.... Development 132 , 2251 -2262. Chen, J. K., Taipale, J., Cooper, M. K. and Beachy, P. A. ( 2002 ). Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev 16 , 2743 -2748. Chen, J. N., Haffter, P., Odenthal, J., Vogelsang, E., Brand,M., van Eeden, F. J., Furutani...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (22): 4987–4998.
Published: 15 November 2005
... is not statistically significant. † Author for correspondence (e-mail: SAA2007@med.cornell.edu ) * These authors contributed equally to this work 14 9 2005 ©2005. 2005 Nkx2.1 Parvalbumin Somatostatin Conditional knockout Smoothened Cell fate determination in the cerebral...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (20): 4461–4470.
Published: 15 October 2005
..., C. ( 1998 ). Zebrafish segmentation and pair-rule patterning. Dev. Genet. 23 , 65 -76. Varga, Z. M., Amores, A., Lewis, K. E., Yan, Y. L.,Postlethwait, J. H., Eisen, J. S. and Westerfield, M. ( 2001 ). Zebrafish smoothened functions in ventral neural tube specification and axon tract...
Journal Articles
Journal: Development
Development (2005) 132 (7): 1579–1590.
Published: 01 April 2005
..., whereas dlx3b and dlx4b are required to restrict pituitary placode size. In smoothened mutant embryos that cannot transduce Hedgehog signals,median pituitary precursors are mis-specified and form an ectopic lens. Moreover, overexpression of sonic hedgehog ( shh ) blocks lens formation, and derivatives...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (17): 3951–3963.
Published: 01 September 2003
... are mediated by the balance between repressor and activator forms of Cubitus interruptus, CiR and CiA. Hedgehog regulates this balance through its receptor, Patched, which acts through Smoothened and thence a regulatory complex that includes Fused, Costal, Suppressor of Fused and Cubitus interruptus...
Journal Articles
Journal: Development
Development (2002) 129 (23): 5323–5337.
Published: 01 December 2002
..., we have used the Cre-loxP system to remove Smoothened(Smo) activity in the dental epithelium. Smo, a seven-pass membrane protein is essential for the transduction of all Hh signals. Hence, removal of Smo activity from the dental epithelium should block Shh signaling within dental epithelial...
Journal Articles
Journal: Development
Development (2001) 128 (18): 3485–3495.
Published: 15 September 2001
... for motoneuron development because the other two can compensate for its loss. Our results also suggest that Twhh and Shh are more important for motoneuron development than Ehh. Hh Smoothened Motoneuron syu smu cyc flh shh ehh twhh Morpholino Ventral neural tube Floor plate Spinal...
Journal Articles
Journal: Development
Development (2001) 128 (12): 2385–2396.
Published: 15 June 2001
... smoothened is unclear, and the role of hedgehog activity in zebrafish is controversial. We show that inactivation of smoothened by retroviral insertions in zebrafish results in defects that are characteristic of hedgehog deficiencies, including abnormalities in body size, the central nervous system, adaxial...