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Keywords: Smooth muscle
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Journal Articles
Journal: Development
Development dev.200625.
Published: 1 August 2022
... various pharmacological inhibitors and BAPX1 gene overexpression in vivo . We found that the enteric nervous system determines the onset of the synchronized contractions in the stomach. Moreover, alteration of smooth muscle fiber organization led to an impairment of this functional activity. Altogether...
Journal Articles
Journal: Development
Development (2022) 149 (4): dev199735.
Published: 17 February 2022
...Jennifer Kurz; Anna-Carina Weiss; Hauke Thiesler; Fairouz Qasrawi; Lena Deuper; Jaskiran Kaur; Carsten Rudat; Timo H. Lüdtke; Irina Wojahn; Herbert Hildebrandt; Mark-Oliver Trowe; Andreas Kispert ABSTRACT The contractile phenotype of smooth muscle cells (SMCs) is transcriptionally controlled...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (10): dev184499.
Published: 22 May 2020
... Morphogen gradients Mechanical stress Smooth muscle Here, we review the biochemical signaling and physical processes that drive branching morphogenesis, and we emphasize how they are integrated to build current conceptual models of the development of the mammalian lung, kidney, salivary gland...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (20): 3733–3741.
Published: 15 October 2016
...Melinda Snitow; MinMin Lu; Lan Cheng; Su Zhou; Edward E. Morrisey During development, the lung mesoderm generates a variety of cell lineages, including airway and vascular smooth muscle. Epigenetic changes in adult lung mesodermal lineages are thought to contribute towards diseases...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (18): 3001–3011.
Published: 15 September 2010
...Mary Redmond Hutson; Xiaopei Lily Zeng; Andrew J. Kim; Emily Antoon; Stephen Harward; Margaret L. Kirby During heart development, a subpopulation of cells in the heart field maintains cardiac potential over several days of development and forms the myocardium and smooth muscle of the arterial pole...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (5): 755–765.
Published: 1 March 2010
... in undifferentiated smooth muscle (SM) progenitors, but was downregulated in differentiating SM cells (SMCs) and had disappeared by E18.5. In Six1 –/– mice, the ureteral mesenchymal precursors failed to condense and differentiate into normal SMCs and showed increased cell death, indicating that Six1 is required...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (19): 3301–3310.
Published: 1 October 2008
... unilateral ureteropelvic junction obstruction in newborn by urinary proteome analysis. Nat. Med. 12 , 398 -400. dell'Agnola, C. A., Carmassi, L. M., Merlo, D. and Tadini,B. ( 1990 ). Duration and severity of congenital hydronephrosis as a cause of smooth muscle deterioration in pyelo-ureteral...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (3): 525–533.
Published: 1 February 2007
... the contribution of these tissues to the bladder and external genitalia. We discovered that development of smooth muscle myosin-positive embryonic bladder mesenchyme requires Shh signaling,and that the bladder mesenchyme and dorsal (upper) external genitalia derive from Shh-responsive peri-cloacal mesenchyme. Thus...
Journal Articles
Journal: Development
Development (2006) 133 (21): 4245–4256.
Published: 1 November 2006
... cardiovascular development, myocardin is the earliest known marker specific to both the cardiac and smooth muscle lineages during embryogenesis. To understand how the expression of this early transcriptional regulator is initiated and maintained, we scanned 90 kb of genomic DNA encompassing the myocardin gene...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (4): 737–749.
Published: 15 February 2006
... is predominantly in the hypaxial somite, adjacent to labelled smooth muscle cells in the aorta. Analysis of Pax3 GFP/+ embryos shows that these cells are Pax3 negative but GFP positive, with fluorescent cells in the intervening region between the aorta and the somite. This is consistent with the direct migration...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (5): 987–997.
Published: 1 March 2005
...Eric M. Small; Andrew S. Warkman; Da-Zhi Wang; Lillian B. Sutherland; Eric N. Olson; Paul A. Krieg Myocardin is a cardiac- and smooth muscle-specific cofactor for the ubiquitous transcription factor serum response factor (SRF). Using gain-of-function approaches in the Xenopus embryo, we show...
Journal Articles
Journal: Development
Development (2004) 131 (9): 2195–2204.
Published: 1 May 2004
... to compensate for the loss of Hand1 . The most striking aspect of the vascular defect in Hand1 mutant yolk sacs is the abnormal distribution of smooth muscle cells. During normal angiogenesis,vascular smooth muscle precursors are recruited to the peri-endothelial tissue before differentiation, however, in Hand1...
Journal Articles
Journal: Development
Development (2002) 129 (22): 5301–5312.
Published: 15 November 2002
..., regulates the timing of differentiation of smooth muscle progenitor cells, and sets the pattern of mesenchymal differentiation through its dose-dependent inhibition of smooth muscle formation. In addition, we also show that bone morphogenetic protein 4 is a downstream target gene of sonic hedgehog signaling...
Journal Articles
Journal: Development
Development (2002) 129 (8): 1905–1912.
Published: 15 April 2002
...Axel A. Thomson; Barry G. Timms; Lesley Barton; Gerald R. Cunha; Oliver C. Grace We have examined the role that smooth muscle plays during prostatic organogenesis and propose that differentiation of a smooth muscle layer regulates prostatic induction by controlling mesenchymal/epithelial...