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Keywords: Smith-Lemli-Opitz syndrome (SLOS)
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Journal Articles

Negative regulation of Hedgehog signaling by the cholesterogenic enzyme 7-dehydrocholesterol reductase

Tetsuya Koide, Tadayoshi Hayata, Ken W. Y. Cho
Journal: Development
Development (2006) 133 (12): 2395–2405.
https://doi.org/10.1242/dev.02393
Published: 15 June 2006
...Tetsuya Koide; Tadayoshi Hayata; Ken W. Y. Cho Cholesterol regulates Hedgehog (Hh) signaling during early vertebrate development. Smith-Lemli-Opitz syndrome (SLOS) is caused by defects in 7-dehydrocholesterol reductase (DHCR7), an enzyme catalyzing the final step of cholesterol biosynthesis. Many...
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Includes: Supplementary data