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Keywords: Smith-Lemli-Opitz syndrome (SLOS)Close
Development (2006) 133 (12): 2395–2405.
Published: 15 June 2006
...Tetsuya Koide; Tadayoshi Hayata; Ken W. Y. Cho Cholesterol regulates Hedgehog (Hh) signaling during early vertebrate development. Smith-Lemli-Opitz syndrome (SLOS) is caused by defects in 7-dehydrocholesterol reductase (DHCR7), an enzyme catalyzing the final step of cholesterol biosynthesis. Many...
Includes: Supplementary data