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Keywords: Small molecule
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Journal Articles
Journal: Development
Development (2017) 144 (20): 3819–3828.
Published: 15 October 2017
... surgically and require complex life-long treatments. Our studies utilized the well-characterized Pax9 −/− mouse model with a consistent cleft palate phenotype to test small-molecule Wnt agonist therapies. We show that the absence of Pax9 alters the expression of Wnt pathway genes including Dkk1 and Dkk2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (19): 3540–3548.
Published: 1 October 2016
... to fertilization are essential for mediating the oocyte-to-embryo transition. Here, we describe a comprehensive small-molecule screen focused on identifying compounds that affect early embryonic events in Caenorhabditis elegans . We identify a single novel compound that disrupts early embryogenesis with remarkable...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (23): 4788–4796.
Published: 1 December 2013
... and the hypostome-specific gene HyBra2 are unchanged. Structure-activity relationship studies have identified features of DAC-2-25 that are required for activity and potency. This study shows that small molecule screens in Hydra can be used to dissect patterning processes. Cnidaria Hydra Pattern...
Includes: Supplementary data