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Keywords: Smad7
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Journal Articles
Journal: Development
Development (2016) 143 (21): 4016–4026.
Published: 1 November 2016
..., but developmental roles for this molecule have not been identified. We show that Tril function is required both upstream and downstream of Bmp receptor-mediated Smad1 phosphorylation for induction of Bmp target genes. Mechanistically, Tril triggers degradation of the Bmp inhibitor Smad7. Tril-dependent...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (23): 5529–5540.
Published: 1 December 2002
... inducers has been elucidated, the relevance of intracellular BMP inhibitors in neural induction is not clear. In order to address this issue and to identify downstream targets after BMP inhibition, we have monitored the transcriptional changes in ectodermal explants neuralized by Smad7 using a Xenopus...