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Keywords: Slit
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Journal Articles
Journal: Development
Development (2020) 147 (20): dev196055.
Published: 29 October 2020
...Riley Kellermeyer; Leah M. Heydman; Taylor Gillis; Grant S. Mastick; Minmin Song; Thomas Kidd ABSTRACT Slit is a secreted protein that has a canonical function of repelling growing axons from the CNS midline. The full-length Slit (Slit-FL) is cleaved into Slit-N and Slit-C fragments, which have...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2018) 145 (2): dev150375.
Published: 17 January 2018
.... It has previously been shown that Slit chemorepellents and their receptors, Robo1 and Robo2, might control the migration of precerebellar neurons in a repulsive manner. Here, we have used a conditional knockout strategy in mice to test this hypothesis. We show that the targeted inactivation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (21): 3990–4001.
Published: 1 November 2017
... that in Drosophila guts lacking the WD40 domain of Atg16, pre-enteroendocrine (pre-EE) cells accumulate that fail to differentiate into properly functioning secretory EE cells. Mechanistically, loss of Atg16 or its binding partner Rab19 impairs Slit production, which normally inhibits EE cell generation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (17): 3037–3044.
Published: 1 September 2016
...Heike Blockus; Alain Chédotal Slits are secreted proteins that bind to Roundabout (Robo) receptors. Slit-Robo signaling is best known for mediating axon repulsion in the developing nervous system. However, in recent years the functional repertoire of Slits and Robo has expanded tremendously...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (20): 3512–3518.
Published: 15 October 2015
...Elly Ordan; Talila Volk Coordinated locomotion of an organism relies on the development of proper musculoskeletal connections. In Drosophila , the Slit-Robo signaling pathway guides muscles to tendons. Here, we show that the Slit receptor Roundabout 2 (Robo2) plays a non-cell-autonomous role...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (8): 1431–1436.
Published: 15 April 2015
... of muscles to tendons, essential for proper locomotion. Previously, the repulsive protein Slit, secreted by tendon cells, has been proposed to be an attractant for muscle migration. However, our findings demonstrate that through tight control of its distribution, Slit repulsion is used for both directing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (8): 1435–1446.
Published: 15 April 2012
... guidance receptor as a likely downstream effector of Nkx2.9; loss of Nkx2.9 leads to a reduction in Robo2 mRNA and protein within SACMNs and SACMN axons fail to exit the spinal cord in Robo2 -deficient mice. Consistent with short-range interactions between Robo2 and Slit ligands regulating SACMN axon exit...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (17): 2885–2894.
Published: 1 September 2010
.... We then searched for the engrailed -dependent agent responsible for these repellent properties. We found slit to be expressed in the P compartment and, using genetic mosaics, present evidence that Slit is the responsible molecule. Blocking the activity of the three Robo genes (putative receptors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (14): 2417–2426.
Published: 15 July 2010
...Hope A. Coleman; Juan-Pablo Labrador; Rebecca K. Chance; Greg J. Bashaw Slits and their Roundabout (Robo) receptors mediate repulsive axon guidance at the Drosophila ventral midline and in the vertebrate spinal cord. Slit is cleaved to produce fragments with distinct signaling properties...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (22): 3643–3653.
Published: 15 November 2008
... trajectories parallel to the floor plate. To identify longitudinal guidance mechanisms in vivo, the overall role of floor plate tissue and the specific roles of Slit/Robo signals were tested. Ectopic induction or genetic deletion of the floor plate diverted longitudinal axons into abnormal trajectories...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (21): 3795–3804.
Published: 1 November 2007
...Marie-Pierre Furrer; Irina Vasenkova; Daichi Kamiyama; Yaira Rosado; Akira Chiba The molecular mechanisms that generate dendrites in the CNS are poorly understood. The diffusible signal molecule Slit and the neuronally expressed receptor Robo mediate growth cone collapse in vivo. However...
Journal Articles
Journal: Development
Development (2007) 134 (2): 273–284.
Published: 15 January 2007
... exhibit a redistribution of β-Spectrin to the axon scaffold.β -spectrin mutants show specific dose-dependent genetic interactions with the midline repellent slit and its neuronal receptor roundabout ( robo ), but not with other guidance molecules. The results suggest that β-Spectrin contributes to midline...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (11): 2243–2252.
Published: 1 June 2006
...William Andrews; Anastasia Liapi; Céline Plachez; Laura Camurri; Jiangyang Zhang; Susumu Mori; Fujio Murakami; John G. Parnavelas; Vasi Sundaresan; Linda J. Richards The Slit genes encode secreted ligands that regulate axon branching,commissural axon pathfinding and neuronal migration...
Journal Articles
Journal: Development
Development (2006) 133 (5): 823–832.
Published: 1 March 2006
... phenotype. To begin an investigation into whether SLITs and ROBOs play a role in mammary gland development, we examined the expression patterns of Slit1,Slit2, Slit3, Robo1 and Robo2 . As Robo4 expression is reported to be specific to the vasculature( Huminiecki et al., 2002 ; Park et al...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (4): 725–735.
Published: 15 February 2006
... optic commissure; black dots mark the position of the optic recess. * Corresponding author (e-mail: Karlstrom@bio.umass.edu ) 19 12 2005 © 2006. 2006 AC Chiasm Commissure Ephrin Gfap Glial bridge Morpholino Netrin POC Semaphorin Slit...
Journal Articles
Journal: Development
Development (2005) 132 (20): 4483–4495.
Published: 15 October 2005
... which molecules mediate this effect in vivo. We show that Slit and Robo proteins are candidate motor axon guidance molecules, as Robo proteins are expressed by cranial motoneurons, and Slit proteins are expressed by the tissues that delimit motor axon trajectories, i.e. the floor plate and the rhombic...
Journal Articles
Journal: Development
Development (2005) 132 (16): 3643–3656.
Published: 15 August 2005
... the expression of Slit guidance molecules that then help to regulate glial cell position and axon guidance across the midline of the forebrain. 3 6 2005 ©2005. 2005 Zebrafish Cyclopamine Morpholino Axon guidance POC Chiasm Gfap Glia hedgehog slit you-too We have...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (23): 5947–5958.
Published: 1 December 2004
... that regulatory elements for the transcription of mau-2 reside more than 1 kb upstream of the gene. * Author for correspondence (e-mail: siegfried.hekimi@mcgill.ca ) 7 9 2004 © 2004. 2004 mau-2 Migration Guidance slt-1 slit Caenorhabditis elegans Maternal effect Cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (15): 3705–3715.
Published: 1 August 2004
...Toshio Miyashita; Sang-Yeob Yeo; Yoshikazu Hirate; Hiroshi Segawa; Hironori Wada; Melissa H. Little; Toshiya Yamada; Naoki Takahashi; Hitoshi Okamoto Slit is a secreted protein known to repulse the growth cones of commissural neurons. By contrast, Slit also promotes elongation and branching...
Journal Articles
Journal: Development
Development (2004) 131 (11): 2587–2594.
Published: 1 June 2004
... evolutionarily conserved signaling molecules, Netrin and Slit, are expressed in the CNS midline cells. Netrin acts primarily as an attractive signaling cue, whereas Slit mediates repulsive functions. Here, we describe a detailed analysis of the Drosophila gene schizo , which is required for commissure formation...