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Keywords: Slit
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Journal Articles
Journal: Development
Development (2020) 147 (20): dev196055.
Published: 29 October 2020
...Riley Kellermeyer; Leah M. Heydman; Taylor Gillis; Grant S. Mastick; Minmin Song; Thomas Kidd ABSTRACT Slit is a secreted protein that has a canonical function of repelling growing axons from the CNS midline. The full-length Slit (Slit-FL) is cleaved into Slit-N and Slit-C fragments, which have...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (2): dev150375.
Published: 17 January 2018
.... It has previously been shown that Slit chemorepellents and their receptors, Robo1 and Robo2, might control the migration of precerebellar neurons in a repulsive manner. Here, we have used a conditional knockout strategy in mice to test this hypothesis. We show that the targeted inactivation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (21): 3990–4001.
Published: 01 November 2017
... that in Drosophila guts lacking the WD40 domain of Atg16, pre-enteroendocrine (pre-EE) cells accumulate that fail to differentiate into properly functioning secretory EE cells. Mechanistically, loss of Atg16 or its binding partner Rab19 impairs Slit production, which normally inhibits EE cell generation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (17): 3037–3044.
Published: 01 September 2016
...Heike Blockus; Alain Chédotal Slits are secreted proteins that bind to Roundabout (Robo) receptors. Slit-Robo signaling is best known for mediating axon repulsion in the developing nervous system. However, in recent years the functional repertoire of Slits and Robo has expanded tremendously...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (20): 3512–3518.
Published: 15 October 2015
...Elly Ordan; Talila Volk Coordinated locomotion of an organism relies on the development of proper musculoskeletal connections. In Drosophila , the Slit-Robo signaling pathway guides muscles to tendons. Here, we show that the Slit receptor Roundabout 2 (Robo2) plays a non-cell-autonomous role...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (8): 1431–1436.
Published: 15 April 2015
... of muscles to tendons, essential for proper locomotion. Previously, the repulsive protein Slit, secreted by tendon cells, has been proposed to be an attractant for muscle migration. However, our findings demonstrate that through tight control of its distribution, Slit repulsion is used for both directing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (8): 1435–1446.
Published: 15 April 2012
... guidance receptor as a likely downstream effector of Nkx2.9; loss of Nkx2.9 leads to a reduction in Robo2 mRNA and protein within SACMNs and SACMN axons fail to exit the spinal cord in Robo2 -deficient mice. Consistent with short-range interactions between Robo2 and Slit ligands regulating SACMN axon exit...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (17): 2885–2894.
Published: 01 September 2010
.... We then searched for the engrailed -dependent agent responsible for these repellent properties. We found slit to be expressed in the P compartment and, using genetic mosaics, present evidence that Slit is the responsible molecule. Blocking the activity of the three Robo genes (putative receptors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (14): 2417–2426.
Published: 15 July 2010
...Hope A. Coleman; Juan-Pablo Labrador; Rebecca K. Chance; Greg J. Bashaw Slits and their Roundabout (Robo) receptors mediate repulsive axon guidance at the Drosophila ventral midline and in the vertebrate spinal cord. Slit is cleaved to produce fragments with distinct signaling properties...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (22): 3643–3653.
Published: 15 November 2008
... trajectories parallel to the floor plate. To identify longitudinal guidance mechanisms in vivo, the overall role of floor plate tissue and the specific roles of Slit/Robo signals were tested. Ectopic induction or genetic deletion of the floor plate diverted longitudinal axons into abnormal trajectories...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (21): 3795–3804.
Published: 01 November 2007
...Marie-Pierre Furrer; Irina Vasenkova; Daichi Kamiyama; Yaira Rosado; Akira Chiba The molecular mechanisms that generate dendrites in the CNS are poorly understood. The diffusible signal molecule Slit and the neuronally expressed receptor Robo mediate growth cone collapse in vivo. However...
Journal Articles
Journal: Development
Development (2007) 134 (2): 273–284.
Published: 15 January 2007
... exhibit a redistribution of β-Spectrin to the axon scaffold.β -spectrin mutants show specific dose-dependent genetic interactions with the midline repellent slit and its neuronal receptor roundabout ( robo ), but not with other guidance molecules. The results suggest that β-Spectrin contributes to midline...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (11): 2243–2252.
Published: 01 June 2006
...William Andrews; Anastasia Liapi; Céline Plachez; Laura Camurri; Jiangyang Zhang; Susumu Mori; Fujio Murakami; John G. Parnavelas; Vasi Sundaresan; Linda J. Richards The Slit genes encode secreted ligands that regulate axon branching,commissural axon pathfinding and neuronal migration...
Journal Articles
Journal: Development
Development (2006) 133 (5): 823–832.
Published: 01 March 2006
... as an adhesive cue,acting in parallel with NTN1 to generate cell boundaries along ducts during bi-layered tube formation. † Author for correspondence (e-mail: hinck@biology.ucsc.edu ) * These authors contributed equally to the work 21 12 2005 © 2006. 2006 Slit Robo Netrin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (4): 725–735.
Published: 15 February 2006
... Morpholino Netrin POC Semaphorin Slit The anterior commissure (AC), post-optic commissure (POC) and the optic chiasm are the first major axon pathways to cross the midline of the vertebrate forebrain during embryonic development. The POC is formed as neurons in the lateral diencephalon...
Journal Articles
Journal: Development
Development (2005) 132 (20): 4483–4495.
Published: 15 October 2005
... which molecules mediate this effect in vivo. We show that Slit and Robo proteins are candidate motor axon guidance molecules, as Robo proteins are expressed by cranial motoneurons, and Slit proteins are expressed by the tissues that delimit motor axon trajectories, i.e. the floor plate and the rhombic...
Journal Articles
Journal: Development
Development (2005) 132 (16): 3643–3656.
Published: 15 August 2005
... the expression of Slit guidance molecules that then help to regulate glial cell position and axon guidance across the midline of the forebrain. ‡ Author for correspondence (e-mail: karlstrom@bio.umass.edu ) * Present address: Biology Department, Smith College, Northampton, MA 01063,USA...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (23): 5947–5958.
Published: 01 December 2004
... mutants. Interestingly, the Gly residue that is mutated in qm4 is conserved through evolution in all animals. * Author for correspondence (e-mail: siegfried.hekimi@mcgill.ca ) 7 9 2004 © 2004. 2004 mau-2 Migration Guidance slt-1 slit Caenorhabditis elegans Maternal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (15): 3705–3715.
Published: 01 August 2004
...Toshio Miyashita; Sang-Yeob Yeo; Yoshikazu Hirate; Hiroshi Segawa; Hironori Wada; Melissa H. Little; Toshiya Yamada; Naoki Takahashi; Hitoshi Okamoto Slit is a secreted protein known to repulse the growth cones of commissural neurons. By contrast, Slit also promotes elongation and branching...
Journal Articles
Journal: Development
Development (2004) 131 (11): 2587–2594.
Published: 01 June 2004
... evolutionarily conserved signaling molecules, Netrin and Slit, are expressed in the CNS midline cells. Netrin acts primarily as an attractive signaling cue, whereas Slit mediates repulsive functions. Here, we describe a detailed analysis of the Drosophila gene schizo , which is required for commissure formation...