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Keywords: Skin
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Journal Articles
Journal: Development
Development (2022) 149 (14): dev200154.
Published: 14 July 2022
... defense. In murine tail skin, interfollicular epidermis patterns into pigmented ‘scale’ and hypopigmented ‘interscale’ epidermis. Why and how mature melanocytes accumulate in scale epidermis is unresolved. Here, we delineate a cellular hierarchy among epidermal cell types that determines skin patterning...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2022) 149 (8): dev199781.
Published: 26 October 2021
...René Reitermaier; Tanya Ayub; Julia Staller; Philip Kienzl; Nikolaus Fortelny; Pablo Augusto Vieyra-Garcia; Christof Worda; Christian Fiala; Clement Staud; Wolfgang Eppel; Anke Scharrer; Thomas Krausgruber; Adelheid Elbe-Bürger ABSTRACT The adult human skin contains a vast number of T cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev194100.
Published: 15 November 2020
... of PNPLA1 or CERS3 in humans results in barrier disruption and skin defects ( Ting et al., 2005 ; de la Garza et al., 2013 ; Eckl et al., 2013 ; Grond et al., 2017 ). Consistent with these findings, Urwyler-Rösselet and colleagues showed that epidermal differentiation defects seen in RIPK4-null...
Journal Articles
Journal: Development
Development (2018) 145 (19): dev168468.
Published: 8 October 2018
... to the skin surface. Here, we demonstrate that the randomly oriented hair phenotype observed in frizzled 6 ( Fzd6 ) mutants results from a partial loss of the polarity, due to the functional redundancy of another closely related frizzled gene, Fzd3 . Double knockout of Fzd3 and Fzd6 globally, or only...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (15): dev165399.
Published: 1 August 2018
... mechanisms of cell fate regulation through niche-derived cues, with a particular focus on epithelial stem cells of the mammalian skin, intestine and lung. We discuss a spectrum of niche-derived biochemical, mechanical and architectural inputs that define stem cell states during morphogenesis, homeostasis...
Journal Articles
Journal: Development
Development (2018) 145 (10): dev160184.
Published: 17 May 2018
...% PFA at 4°C. Embryos were then washed in PBS and skins were dissected and processed for immunostaining as described above. After incubation with secondary antibody, skins were washed extensively in PBS and incubated in the Click-iT reaction cocktail for 1 h at room temperature. Skins were then washed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (22): 4078–4090.
Published: 15 November 2017
...Blair A. Jenkins; Ellen A. Lumpkin The sensation of touch is mediated by mechanosensory neurons that are embedded in skin and relay signals from the periphery to the central nervous system. During embryogenesis, axons elongate from these neurons to make contact with the developing skin...
Journal Articles
Journal: Development
Development (2016) 143 (12): 2077–2088.
Published: 15 June 2016
... cellular processes that take place both within the epidermis and in other participating tissues. Re-epithelialization of partial- or full-thickness skin wounds of adult zebrafish, however, is extremely rapid and largely independent of the other processes of wound healing. Live imaging after treatment...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (12): 2194–2202.
Published: 15 June 2015
... and Ift27 −/− skin at various developmental stages ( Fig. 4 A; supplementary material Fig. S7 ; data not shown). Scanning electron microscopy of primary keratinocytes isolated from control and Ift27 −/− embryos also revealed primary cilia of comparable appearance ( supplementary material Fig. S8...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (24): 4690–4696.
Published: 15 December 2014
...Carolina N. Perdigoto; Evan S. Bardot; Victor J. Valdes; Francis J. Santoriello; Elena Ezhkova Merkel cell–neurite complexes are located in touch-sensitive areas of the mammalian skin and are involved in recognition of the texture and shape of objects. Merkel cells are essential for these tactile...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (20): 3944–3954.
Published: 15 October 2014
... interests. 15 3 2014 14 8 2014 © 2014. Published by The Company of Biologists Ltd 2014 Planar cell polarity Skin Brain Hair follicle Tongue Mouse Complex metazoan animals are replete with structures that exhibit a high degree of spatial order. One type of order...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (4): 807–815.
Published: 15 February 2014
... ontogeny has not been determined yet. These elusive precursors are believed to migrate into the embryonic skin and to express primitive surface markers, including CD36, but not typical LC markers such as CD1a, CD1c and CD207. The aim of this study was to further characterize the phenotype of LC precursors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (18): 3809–3818.
Published: 15 September 2013
... follicle stem cells are maintained in a quiescent state until they receive signals to proliferate. We found that the forkhead transcription factor Foxp1 is crucial for maintaining the quiescence of hair follicle stem cells. Loss of Foxp1 in skin epithelial cells leads to precocious stem cell activation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (8): 1655–1664.
Published: 15 April 2013
... Skin Mouse The hair follicle (HF) has emerged as an informative system in which to study adult stem cell biology because it is characterized by predictable and precisely choreographed phases of growth (anagen), regression (catagen) and rest (telogen; Fig. 1A ). Hair growth is, in part...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (7): 1517–1527.
Published: 1 April 2013
...Barbara A. Schmidt; Valerie Horsley Acute wound healing in the skin involves the communication of multiple cell types to coordinate keratinocyte and fibroblast proliferation and migration for epidermal and dermal repair. Many studies have focused on the interplay between hematopoietic cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (22): 4152–4161.
Published: 15 November 2012
...Zhu Juan Li; Erica Nieuwenhuis; Weilun Nien; Xiaoyun Zhang; Jennifer Zhang; Vijitha Puviindran; Brandon J. Wainwright; Peter C. W. Kim; Chi-chung Hui Abnormal activation of Hedgehog (Hh) signaling leads to basal cell carcinoma (BCC) of the skin, the most common human cancer. Gli2, the major...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (22): 4210–4219.
Published: 15 November 2012
... defense against micro-organisms and in the pathophysiology of several inflammatory skin diseases. To understand the role of TLRs in the acquisition of immunological competence, we conducted a comprehensive study to evaluate TLR expression and function in the developing human skin before and after birth...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (8): 1405–1416.
Published: 15 April 2012
...; however, little is known of their functions in postnatal hair growth. We compared the effects of deleting the essential miRNA biogenesis enzymes Drosha and Dicer in mouse skin epithelial cells at successive postnatal time points. Deletion of either Drosha or Dicer during an established growth phase...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (4): 740–748.
Published: 15 February 2012
...Seung-Hyun Woo; Yoshichika Baba; Alexa M. Franco; Ellen A. Lumpkin; David M. Owens The piloneural collar in mammalian hairy skin comprises an intricate pattern of circumferential and longitudinal sensory afferents that innervate primary and secondary pelage hairs. The longitudinal afferents tightly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (22): 4843–4852.
Published: 15 November 2011
... essential roles in morphogenesis and patterning of ectodermal derivatives as well as in controlling stem cell activity. Here, we show that during murine skin morphogenesis, Lhx2 is expressed in the hair follicle (HF) buds, whereas in postnatal telogen HFs Lhx2 + cells reside in the stem cell-enriched...
Includes: Supplementary data