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Keywords: Six2
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Journal Articles
Journal: Development
Development (2020) 147 (1): dev177022.
Published: 3 January 2020
... human erythropoiesis in vitro . GATA SIX1 SIX2 Retinal determination gene network PAX-SIX-EYA-DACH network Hematopoiesis GATA transcription factors orchestrate the development of diverse tissues across taxa and act at multiple stages during tissue development, including stem...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (24): 4530–4539.
Published: 15 December 2017
... development Wnt4 Six2 Mouse In mammals, nephrons are formed only during development ( McMahon, 2016 ). At the cortex of the developing kidney, mesenchymal nephron progenitors reside adjacent to the branching tips of the collecting duct. At each branching event, a subset of nephron progenitors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (21): 3907–3913.
Published: 1 November 2016
..., Notch signaling promotes the formation of proximal tubules and represses the formation of distal tubules. Here, we present a novel role of Notch in nephrogenesis. We show in mice that differentiation of nephron progenitors requires downregulation of Six2, a transcription factor required for progenitor...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (7): 1442–1452.
Published: 1 April 2014
...Jingyue Xu; Han Liu; Joo-Seop Park; Yu Lan; Rulang Jiang Mammalian kidney organogenesis involves reciprocal epithelial-mesenchymal interactions that drive iterative cycles of nephron formation. Recent studies have demonstrated that the Six2 transcription factor acts cell autonomously to maintain...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (7): 1247–1257.
Published: 1 April 2011
..., at least in part, on the activity of the transcription factor Six2. Six2-positive cells that receive the Wnt9b signal are maintained as progenitors whereas cells with reduced levels of Six2 are induced to differentiate by Wnt9b. Using this simple mechanism, the kidney is able to balance progenitor cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (8): 1463–1470.
Published: 15 April 2008
... the positional information encoded by Hox genes is translated into morphogenetic changes. Here, we conclusively demonstrate that Six2 is a direct downstream target of Hoxa2 in vivo and show that the ectopic expression of Six2 , observed in the absence of Hoxa2, contributes to the Hoxa2 mouse mutant phenotype. We...
Journal Articles
Journal: Development
Development (2005) 132 (3): 469–478.
Published: 1 February 2005
... branchial arch derivatives is unclear. We show that Six2, another transcription factor, is genetically downstream of Hoxa2. High levels of Six2 are observed in the Hoxa2 loss-of-function mutant. By using a transgenic approach to overexpress Six2 in the embryonic area controlled by Hoxa2 , we observed...
Journal Articles
Journal: Development
Development (2003) 130 (14): 3085–3094.
Published: 15 July 2003
...Pin-Xian Xu; Weiming Zheng; Li Huang; Pascal Maire; Christine Laclef; Derek Silvius The murine Six gene family, homologous to Drosophila sine oculis ( so ) which encodes a homeodomain transcription factor, is composed of six members ( Six1-6 ). Among the six members, only the Six2 gene has been...