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Keywords: Single cell RNA-seq
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Journal Articles
Journal: Development
Development (2023) 150 (23): dev201972.
Published: 6 December 2023
... exploration of molecular signalling in the human developmental haematopoietic stem cell niche at the spatial and single cell level. Haematopoiesis Human development Spatial transcriptomics Single cell RNA-seq AGM region Medical Research Council http://dx.doi.org/10.13039/501100000265...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (14): dev185777.
Published: 20 July 2020
... diversification of synovial joint constituents. To address this, we have performed single cell RNA-Seq analysis of 7329 synovial joint progenitor cells from the developing murine knee joint from E12.5 to E15.5. By using a combination of computational analytics, in situ hybridization and in vitro characterization...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (9): dev183855.
Published: 5 May 2020
... with age. Here, we use time-lapse imaging and single cell RNA-seq to measure activation trajectories and rates in young and aged MuSCs. We find that the activation trajectory is conserved in aged cells, and we develop effective machine-learning classifiers for cell age. Using cell-behavior analysis and RNA...
Includes: Supplementary data
Journal Articles
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Neural development
Journal: Development
Development (2019) 146 (17): dev179556.
Published: 2 September 2019
.../ Highlighted Article: Differences in miRNA expression in Müller glia and retinal progenitor cells account for the dissimilarities in their neurogenic potential. Such differences could be manipulated to reprogram MG for retinal regeneration. Retina Reprogramming miRNAs Single cell RNA-seq Ascl1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (12): dev169854.
Published: 27 June 2019
... Single cell RNA-seq In 1665, Robert Hooke coined the term ‘cell’ to describe the micro unit of biological tissues ( Hooke, 1665 ). Continued efforts on cells culminated in ‘cell theory’, the central tenet of which is the now well-accepted assertion of the cell as the basic unit of all living...
Journal Articles
Journal: Development
Development (2019) 146 (12): dev180398.
Published: 14 June 2019
.../ Summary: Using single cell transcriptomics to inspect Pitx2 function in cardiac development and left-right cellular specification, this study characterizes all deviations in cell composition, cellular state and differentiation trajectories. Pitx2 Left-right asymmetry Single cell RNA-seq Cardiac...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2019) 146 (12): dev174177.
Published: 11 April 2019
... with partially overlapping but distinct transcriptional signatures. Muscle stem cells Satellite cells Single cell RNA-seq Muscle regeneration Mouse Growth and homeostasis of the skeletal muscle system, a tissue/organ constituting approximately 35% of the human total body mass ( Janssen et al...
Includes: Supplementary data