... diversification of synovial joint constituents. To address this, we have performed single cell RNA-Seq analysis of 7329 synovial joint progenitor cells from the developing murine knee joint from E12.5 to E15.5. By using a combination of computational analytics, in situ hybridization and in vitro characterization...

... with age. Here, we use time-lapse imaging and single cell RNA-seq to measure activation trajectories and rates in young and aged MuSCs. We find that the activation trajectory is conserved in aged cells, and we develop effective machine-learning classifiers for cell age. Using cell-behavior analysis and RNA...

.... Such differences could be manipulated to reprogram MG for retinal regeneration. Retina Reprogramming miRNAs Single cell RNA-seq Ascl1 Adult In fish and birds, Müller glial cells (MG) respond to injury of the retina by re-entering the cell cycle and generating retinal progenitor-like cells...

...: This Hypothesis proposes a periodic table that aligns cell types according to their developmental stages, connecting them to one another according to the universal axis from stem cells to differentiated cells. Cell atlas Cell states Cell types Periodic table Single cell RNA-seq In 1665, Robert...

... discovered a population of immune cells expressing high levels of Gata1 ( Fig. S1A ). Here, we used single cell transcriptomics to inspect Pitx2 function in cardiac development and left-right cellular specification. Deployment of a high-throughput single cell RNA-seq (scRNA-seq) platform...

.... Kidney development Single cell RNA-seq Organogenesis Nephron progenitor Ureteric epithelium Mammalian kidney development has been studied using the mouse for over 70 years. The developing mammalian kidney consists of three main cell lineages, all of which derive from multipotent progenitors...

... , Y. , Yao , J. , Li , Z. , Huang , Y. and Wang , J. ( 2019 ). Comparative analysis of droplet-based ultra-high-throughput single-cell RNA-seq systems . Mol. Cell   73 , 130 - 142.e5 . 10.1016/j.molcel.2018.10.020 Zheng , J. , Lu , Z. , Kocabas , F...