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Keywords: Sim2
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Journal Articles
Journal: Development
Development (2021) 148 (17): dev199265.
Published: 6 September 2021
... throughout all stages of curvature was single-minded 2 ( sim2 ), a Down Syndrome-related transcription factor and homolog of a Drosophila gene ( sim ) required for LR asymmetric looping of the fly gut. We demonstrate that sim2 functions downstream of LR patterning cues to regulate key cellular properties...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2005) 132 (24): 5527–5537.
Published: 15 December 2005
.... The bHLH-PAS transcription factors SIM1 and SIM2 are co-expressed in the developing MB. We have found that MB neurons are generated and that they survive at least until E18.5 in embryos lacking both Sim1 and Sim2 ( Sim1 -/- ; Sim2 -/- ). However, the MTT and MTEG are histologically absent in Sim1 -/- ;Sim2...
Journal Articles
Journal: Development
Development (2000) 127 (21): 4701–4709.
Published: 1 November 2000
... with the expression of Sim2. Sim2 encodes a basic helix-loop-helix (bHLH-PAS) PAS domain containing transcriptional regulator whose Drosophila homolog, single-minded , is a master regulator of ventral midline development. Both vertebrate and invertebrate Sim family members were found sufficient for the activation...