...Isabel Mogollón; Jacqueline E. Moustakas-Verho; Minna Niittykoski; Laura Ahtiainen ABSTRACT Signaling centers, or organizers, regulate many aspects of embryonic morphogenesis. In the mammalian molar tooth, reiterative signaling in specialized centers called enamel knots (EKs) determines tooth...

..., root-forming cervical loops and enamel-forming ameloblasts. Enamel knots are signaling centers that define the positions of cusp tips in a tooth by instructing the adjacent epithelium to fold and proliferate. Here, we show that the forkhead-box transcription factor Foxi3 inhibits formation of enamel...

... development than previously recognized, and emphasize that two major signaling centers interact antagonistically to pattern cerebral cortex. Hem ablation had less obvious effects on indicators of BMP signaling, possibly because BMP ligands are secreted by choroid plexus epithelium (CPe), and are available...

... 1 2013 © 2013. Published by The Company of Biologists Ltd 2013 Astrocytes Ependymal zone Hedgehog Oligodendrocytes Stem cells Signaling center Mouse During vertebrate embryogenesis, pattern formation and cell fate specification are directed by signaling...

...Victor V. Chizhikov; Anne G. Lindgren; D. Spencer Currle; Matthew F. Rose; Edwin S. Monuki; Kathleen J. Millen During embryogenesis, the isthmic organizer, a well-described signaling center at the junction of the mid-hindbrain, establishes the cerebellar territory along the anterior/posterior axis...

...Lori M. Zeltser The zona limitans intrathalamica (ZLI) is located at the border between the prospective ventral thalamus and dorsal thalamus, and functions as a diencephalic signaling center. Little is known about the mechanism controlling ZLI formation. Using a combination of fate-mapping studies...