1-20 of 61
Keywords: Signaling
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
Journal: Development
Development (2021) 148 (23): dev199465.
Published: 14 December 2021
... muscle depends on Anaplastic Lymphoma Kinase (Alk) receptor tyrosine kinase (RTK) signaling, which specifies founder cells (FCs) in the circular visceral mesoderm (VM). Although Alk activation by its ligand Jelly Belly (Jeb) is well characterized, few target molecules have been identified. Here, we used...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (9): dev195552.
Published: 29 April 2021
...Emily K. Ho; Tim Stearns ABSTRACT The mechanisms of vertebrate Hedgehog signaling are linked to the biology of the primary cilium, an antenna-like organelle that projects from the surface of most vertebrate cell types. Although the advantages of restricting signal transduction to cilia are often...
Journal Articles
Journal: Development
Development (2021) 148 (8): dev197087.
Published: 23 April 2021
...José Esteban-Collado; Montserrat Corominas; Florenci Serras ABSTRACT Regeneration after damage requires early signals to trigger the tissue repair machinery. Reactive oxygen species (ROS) act as early signals that are sensed by the MAP3 kinase Ask1, which in turn activates by phosphorylation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (5): dev189753.
Published: 9 March 2021
... replenishment versus cell incorporation into organ primordia. The WUSCHEL (WUS)/CLAVATA (CLV) negative feedback loop is central to SAM size regulation. Its correct function depends on accurate spatial expression of WUS and CLV3 . A signaling pathway, consisting of ERECTA family (ERf) receptors and EPIDERMAL...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (9): dev188573.
Published: 4 May 2020
... to dysfunction in a human 3D model of placental microvasculature through VEGF-Ang-Tie2 signaling . Adv. Sci.   6 , 1900878 . 10.1002/advs.201900878 Hyun , I. , Munsie , M. , Pera , M. F. , Rivron , N. C. and Rossant , J. ( 2020 ). Toward guidelines for research on human embryo...
Journal Articles
Journal: Development
Development (2020) 147 (7): dev184507.
Published: 6 April 2020
... and myoblast pools. We reveal that the non-cell-autonomous effect of MyHC-emb on myogenic progenitors and myoblasts is mediated by the fibroblast growth factor (FGF) signaling pathway, and exogenous FGF rescues the myogenic differentiation defects upon loss of MyHC-emb function in vitro . Adult Myh3 null mice...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev175067.
Published: 22 October 2019
... cell cycle dynamics and cortical actomyosin contractility during early Drosophila embryogenesis. They adopted an optogenetic system to stimulate Rho signaling and apical constriction ( Fig. 4 C,D; see below) ( Izquierdo et al., 2018 ) to increase the contractility of cortical actomyosin during early...
Journal Articles
Journal: Development
Development (2019) 146 (13): dev167502.
Published: 4 July 2019
... in mouse and zebrafish embryos that are deficient in RA-generating enzymes or RARs have been instrumental in identifying RA functions, revealing that RA signaling regulates development of many organs and tissues, including the body axis, spinal cord, forelimbs, heart, eye and reproductive tract...
Journal Articles
Journal: Development
Development (2019) 146 (10): dev173328.
Published: 28 May 2019
... and FGF signaling in culture. The analysis of gremlin 1 ( Grem1 )-deficient forelimb buds showed that JAG1-expressing LMPs are protected from apoptosis by GREM1-mediated BMP antagonism. At the same stage, the osteo-chondrogenic progenitors (OCPs) located in the core mesenchyme are already actively...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (3): dev172148.
Published: 1 February 2019
... in development and disease. Recent studies suggest that this versatility in Notch function may not necessarily arise from complex and context-dependent integration of Notch signaling with other developmental signals, but instead arises, in part, from signaling dynamics. Here, we review recent findings...
Journal Articles
Journal: Development
Development (2018) 145 (24): dev166850.
Published: 12 December 2018
...Cecile Giordano; Laurent Ruel; Candice Poux; Pascal Therond ABSTRACT Hedgehog (Hh) is a conserved morphogen that controls cell differentiation and tissue patterning in metazoans. In Drosophila , the Hh signal is transduced from the G protein-coupled receptor Smoothened (Smo) to the cytoplasmic Hh...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (13): dev163378.
Published: 2 July 2018
...Tania Papoutsi; Luis Luna-Zurita; Belén Prados; Stéphane Zaffran; José Luis de la Pompa ABSTRACT Signaling interactions between the myocardium and endocardium pattern embryonic cardiac regions, instructing their development to fulfill specific functions in the mature heart. We show that ectopic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev152595.
Published: 8 January 2018
...Delong Meng; Anderson R. Frank; Jenna L. Jewell ABSTRACT The mammalian target of rapamycin (mTOR) senses nutrients and growth factors to coordinate cell growth, metabolism and autophagy. Extensive research has mapped the signaling pathways regulated by mTOR that are involved in human diseases...
Journal Articles
Journal: Development
Development (2017) 144 (22): 4148–4158.
Published: 15 November 2017
... matrix interactions. Integrins are heterodimeric transmembrane receptors consisting of α and β subunits; crucial integrins in the kidney collecting system express the β1 subunit. The β1 cytoplasmic tail has two NPxY motifs that mediate functions by binding to cytoplasmic signaling and scaffolding...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2017) 144 (12): 2187–2199.
Published: 15 June 2017
... housekeeping function, as well as an extracellular signaling function mediated by the secreted MSPd. Here we show that the C. elegans VAP homolog VPR-1 is essential for gonad development. vpr-1 null mutants are maternal effect sterile due to arrested gonadogenesis following embryo hatching. Somatic gonadal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (23): 4521–4532.
Published: 1 December 2016
... underlying cavefish sensory evolution, we analyzed the roles of Shh, Fgf8 and Bmp4 signaling, which are known to be fundamental in patterning the vertebrate head and are subtly modulated in space and time during cavefish embryogenesis. Modulating these signaling systems at the end of gastrulation shifted...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2016) 143 (18): 3238–3248.
Published: 15 September 2016
...Marc Somssich; Byoung Il Je; Rüdiger Simon; David Jackson Shoot meristems are maintained by pluripotent stem cells that are controlled by CLAVATA-WUSCHEL feedback signaling. This pathway, which coordinates stem cell proliferation with differentiation, was first identified in Arabidopsis...
Journal Articles
Journal: Development
Development (2016) 143 (12): 2228–2237.
Published: 15 June 2016
...Sho Ohta; Baolin Wang; Suzanne L. Mansour; Gary C. Schoenwolf The inner ear consists of two otocyst-derived, structurally and functionally distinct components: the dorsal vestibular and ventral auditory compartments. BMP signaling is required to form the vestibular compartment, but how...
Journal Articles
Journal: Development
Development (2015) 142 (19): 3253–3262.
Published: 1 October 2015
... can produce diverse signals that have a profound impact on neighboring cells and tissues. For example, apoptotic cells can release factors that influence the proliferation and survival of adjacent tissues. Apoptosis can also affect tissue movement and morphogenesis by modifying tissue tension...
Journal Articles
Journal: Development
Development (2015) 142 (8): 1480–1491.
Published: 15 April 2015
...Kevin Legent; Hui Hua Liu; Jessica E. Treisman Endocytic trafficking of signaling receptors is an important mechanism for limiting signal duration. Components of the Endosomal Sorting Complexes Required for Transport (ESCRT), which target ubiquitylated receptors to intra-lumenal vesicles (ILVs...
Includes: Supplementary data