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Keywords: Sex determination
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Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (16): dev199646.
Published: 23 August 2021
... and juxtacortical medulla, independently of the supporting cell sex lineage. TGIF1 Ovarian cortex Juxtacortical medulla Gonadal development Sex determination Chicken embryo Australian Research Council http://dx.doi.org/10.13039/501100000923 200100709 Vertebrate gonadal sex...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (17): dev192856.
Published: 11 September 2020
... maintains female identity in Drosophila germ cells . Nat. Commun.   9 , 4155 . 10.1038/s41467-018-06697-x Staab , S. , Heller , A. and Steinmann-Zwicky , M. ( 1996 ). Somatic sex-determining signals act on XX germ cells in Drosophila embryos . Development   122 , 4065 - 4071...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (4): dev181693.
Published: 25 February 2020
.... For manipulation of oestrogen levels after sex determination (late treatment), eggs were incubated at 37.7°C pointed end down. At D7-7.5 (HH31) or D9 (HH35) a first injection in the air chamber was performed through a hole made at the rounded end. To downregulate oestrogen, the P450 aromatase inhibitor fadrozole...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (19): dev179663.
Published: 23 August 2019
...://www.biologists.com/user-licence-1-1/ Summary: CLAMP-MSL2 and MSL2(CXC)-DNA interactions contribute cooperatively to the recruitment of the dosage compensation complex to the X chromosome in Drosophila . MSL CLAMP Sex determination Transcription factor C2H2 zinc finger CXC In Drosophila...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (7): dev162537.
Published: 9 April 2018
... ). Evolution of an expanded sex-determining locus in Volvox . Science   328 , 351 - 354 . 10.1126/science.1186222 Fukada , K. , Inoue , T. and Shiraishi , H. ( 2006 ). A posttranslationally regulated protease, VheA, is involved in the liberation of juveniles from parental spheroids...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2018) 145 (1): dev150821.
Published: 8 January 2018
... underlying their female-specific generation. We demonstrate that programmed cell death (PCD) eliminates FS-Ilp7 motoneurons in males, and that this requires male-specific splicing of the sex-determination gene fruitless ( fru ) into the Fru MC isoform. However, in females, fru alleles that only generate Fru...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (4): 720–730.
Published: 15 February 2017
... challenging in the context of developing tissues where material is limited and cell types are mixed. To identify regulatory sites during sex determination, we subjected Sertoli cells from mouse fetal testes to DNaseI-seq and ChIP-seq for H3K27ac. DNaseI-seq identified putative regulatory sites around genes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (10): 1633–1637.
Published: 15 May 2016
... was this mouse so special? The mouse in question was a chromosomal female (XX) made male by the presence of a transgene containing the Y chromosome gene Sry . This sex-reversal provided clear experimental proof that Sry was the elusive mammalian sex-determining gene. Twenty-five years on, we reflect on what...
Journal Articles
Journal: Development
Development (2015) 142 (6): 1083–1088.
Published: 15 March 2015
...Liang Zhao; Terje Svingen; Ee Ting Ng; Peter Koopman Genes related to Dmrt1 , which encodes a DNA-binding DM domain transcription factor, act as triggers for primary sex determination in a broad range of metazoan species. However, this role is fulfilled in mammals by Sry , a newly evolved gene...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (3): 575–586.
Published: 1 February 2015
...Quan Wu; Kurumi Fukuda; Michael Weinstein; Jonathan M. Graff; Yumiko Saga The sex of primordial germ cells (PGCs) is determined in developing gonads on the basis of cues from somatic cells. In XY gonads, sex-determining region Y (SRY) triggers fibroblast growth factor 9 (FGF9) expression in somatic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (11): 2195–2205.
Published: 1 June 2014
...Christian Larney; Timothy L. Bailey; Peter Koopman Mammalian sex determination hinges on the development of ovaries or testes, with testis fate being triggered by the expression of the transcription factor sex-determining region Y ( Sry ). Reduced or delayed Sry expression impairs testis...
Journal Articles
Journal: Development
Development (2011) 138 (13): 2761–2771.
Published: 1 July 2011
.... 2011 DamID Doublesex Evolution Sex determination Transcription factor binding site Although many of the regulatory hierarchies governing development have been elucidated, progress has been slow in identifying the direct targets of the terminal regulatory genes in these hierarchies...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (9): 1759–1769.
Published: 1 May 2011
... at times when HES family members are active and limits Hey and HES family activity during sex determination, segmentation and neurogenesis. We show that Dgrn interacts with the Notch signaling pathway by it antagonizing the activity of E(spl)-C proteins. dgrn null mutants are female sterile, producing...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (23): 3921–3930.
Published: 1 December 2010
...Kenichi Kashimada; Peter Koopman SRY, the mammalian Y-chromosomal testis-determining gene, induces male sex determination. Recent studies in mice reveal that the major role of SRY is to achieve sufficient expression of the related gene Sox9, in order to induce Sertoli cell differentiation, which...
Journal Articles
Journal: Development
Development (2010) 137 (15): 2519–2526.
Published: 1 August 2010
...Shin Yoshimoto; Nozomi Ikeda; Yumi Izutsu; Tadayoshi Shiba; Nobuhiko Takamatsu; Michihiko Ito A Y-linked gene, DMY/dmrt1bY , in teleost fish medka and a Z-linked gene, DMRT1 , in chicken are both required for male sex determination. We recently isolated a W-linked gene, DM-W , as a paralogue...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (2): 323–332.
Published: 15 January 2010
... the tools for dissecting how neurogenesis and neuronal differentiation are modulated by the Drosophila sex-determination regulatory genes to produce nervous system sexual dimorphisms. Here we report studies aimed at illuminating the basis of the sexual dimorphic axonal projection patterns of foreleg...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (23): 3881–3887.
Published: 1 December 2009
... animals (1X:2A=0.5) develop as males. TRA-1, the worm ortholog of Drosophila Cubitus interruptus and mammalian Gli (Glioma-associated homolog) proteins, is the terminal transcription factor of the C. elegans sex-determination pathway, which specifies hermaphrodite fate by repressing male-specific genes...
Journal Articles
Journal: Development
Development (2009) 136 (22): 3821–3830.
Published: 15 November 2009
...Abbie L. Casper; Mark Van Doren The establishment of sexual identity is a crucial step of germ cell development in sexually reproducing organisms. Sex determination in the germline is controlled differently than in the soma, and often depends on communication from the soma. To investigate how...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (14): 2373–2382.
Published: 15 July 2008
...D. Adam Mason; Jeremy S. Rabinowitz; Douglas S. Portman Although sexual dimorphism is ubiquitous in animals, the means by which sex determination mechanisms trigger specific modifications to shared structures is not well understood. In C. elegans, tail tip morphology is highly dimorphic: whereas...
Journal Articles
Journal: Development
Development (2007) 134 (23): 4199–4208.
Published: 1 December 2007
... functional testes. We show that the chick gonads already have distinct morphological and molecular left-right(L-R) characteristics in both sexes at indifferent (genital ridge) stages and that these persist, becoming more elaborate during sex determination and differentiation, but have no consequences...
Includes: Supplementary data