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Keywords: Serrate
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Journal Articles
Journal: Development
Development (2007) 134 (12): 2369–2378.
Published: 15 June 2007
... for correspondence (e-mail: n.daudet@ucl.ac.uk ) * These authors contributed equally to this work 26 3 2007 © 2007. 2007 Notch signalling Serrate Delta Chick embryo Inner ear Otic placode Neuroblasts Hair cell Lateral inhibition Lateral induction The vertebrate inner ear...
Journal Articles
Journal: Development
Development (2006) 133 (23): 4771–4781.
Published: 1 December 2006
... concerning the genes required for survival during the early cell-proliferation phase. Here, we show that Lobe ( L ) and the Notch (N) ligand Serrate ( Ser ), which are both involved in ventral eye growth, are required for cell survival in the early eye disc. We observed that the loss-of-ventral-eye phenotype...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (12): 2883–2894.
Published: 15 June 2005
...Weidong Wang; Gary Struhl Ligands of the Delta/Serrate/Lag2 (DSL) family must normally be endocytosed in signal-sending cells to activate Notch in signal-receiving cells. DSL internalization and signaling are promoted in zebrafish and Drosophila , respectively, by the ubiquitin ligases Mind bomb...
Journal Articles
Journal Articles
Journal: Development
Development (2005) 132 (1): 123–132.
Published: 1 January 2005
... for an active protease domain in Kul. A similar mutation abolished the catalytic activity of Kuz ( Pan and Rubin,1997 ). Fig. 1. Several Drosophila ADAM metalloproteases cleave Delta and Serrate in S2 cells. (A) Phylogenetic tree of ADAM metalloproteases. Drosophila in bold, Anopheles in gray, C...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (4): 733–742.
Published: 15 February 2004
... on the differential expression pattern of T-Sp8 in the appendages of the head and the thorax and the RNAi phenotype, we hypothesise that T-Sp8 is involved in the regulation of limb-length in relation to body size - a process called allometric growth. Tribolium Sp8 Leg elongation Allometric growth Serrate...
Journal Articles
Journal: Development
Development (2004) 131 (2): 285–298.
Published: 15 January 2004
... signaling molecules. In order to understand how the integration of multiple signaling pathways and selector proteins can be achieved during wing development, we studied the regulatory network that controls the expression of Serrate (Ser), a ligand for the Notch(N) signaling pathway, which is essential...
Journal Articles
Journal: Development
Development (2003) 130 (25): 6351–6360.
Published: 22 December 2003
... pannier ( pnr ) controls Iroquois-Complex ( Iro-C ) genes to establish the dorsal eye fate whereas Lobe ( L ), which is involved in controlling a Notch ligand Serrate ( Ser ), is specifically required for ventral growth. However, fate of eye disc cells before the onset of dorsal expression of pnr and Iro...
Journal Articles
Journal: Development
Development (2003) 130 (24): 6089–6099.
Published: 15 December 2003
... of the Hes1 promoter that was functional in Notch response assays (data not shown). We therefore tested whether BMP4 altered the levels of mRNA for the two most commonly analyzed Notch ligands, Dll1 and Serrate 1 . Expression was analyzed at 0 and 5 days after the induction of differentiation...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2001) 128 (22): 4511–4521.
Published: 15 November 2001
... arise. I further demonstrate that the proximal-distal patterning genes homothorax and dachshund are positively required, while Distal-less is unexpectedly negatively required, to establish the segmental pattern of Notch ligand and fringe expression. Two Serrate enhancers that respond to regulation...
Journal Articles
Journal Articles
Journal: Development
Development (2000) 127 (17): 3865–3876.
Published: 1 September 2000
... evidence that activation of Notch by its ligand Serrate apportions myogenic and non-myogenic cell fates within the early Xenopus heart field. The crescent-shaped field of heart mesoderm is specified initially as cardiomyogenic. While the ventral region of the field forms the myocardial tube...
Journal Articles
Journal Articles
Journal: Development
Development (2000) 127 (14): 3069–3078.
Published: 15 July 2000
... development by its target gene dLMO . Apterous-dependent expression of Serrate and fringe in dorsal cells leads to the restricted activation of Notch along the dorsoventral compartment boundary. We present evidence that the ability of cells to participate in this Apterous-dependent cell-interaction is under...
Journal Articles
Journal: Development
Development (1999) 126 (13): 2993–3003.
Published: 1 July 1999
...S. A. Bishop; T. Klein; A. Martinez Arias; J. P. Couso ABSTRACT The receptor protein NOTCH and its ligands SERRATE and DELTA are involved in many developmental processes in invertebrates and vertebrates alike. Here we show that the expression of the Serrate and Delta genes patterns the segments...
Journal Articles
Journal: Development
Development (1999) 126 (9): 1985–1995.
Published: 1 May 1999
... architecture. We have identified the Drosophila signaling protein Serrate as the product of a Hox downstream gene that acts in many segments as a component of such pathways. In the embryonic epidermis, Serrate is required for morphogenesis of normal abdominal denticle belts and maxillary mouth hooks, both Hox...
Journal Articles
Journal: Development
Development (1998) 125 (23): 4637–4644.
Published: 1 December 1998
... gene expression. Similar misregulation of delta genes is seen in the ear, along with misregulation of a Serrate homologue, serrateB , coding for an alternative Notch ligand. Most dramatically, the sensory patches in the mind bomb ear consist solely of hair cells, which are produced in great excess...
Journal Articles
Journal: Development
Development (1998) 125 (22): 4531–4540.
Published: 15 November 1998
...Thomas L. Jacobsen; Keith Brennan; Alfonso Martinez Arias; Marc A. T. Muskavitch ABSTRACT We find that ectopic expression of Delta or Serrate in neurons within developing bristle organs is capable of non-autonomously inducing the transformation of the pre-trichogen cell into a tormogen cell...
Journal Articles
Journal: Development
Development (1998) 125 (15): 2951–2962.
Published: 1 August 1998
..., which regulates the expression of the Notch ligand, Serrate, and the Fringe signalling molecule. The other Notch ligand, Delta, also plays a role in the development and patterning of the wing. It has been proposed that Fringe modulates the ability of Serrate and Delta to signal through Notch and thereby...