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Keywords: Semaphorin
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Journal Articles
In collection:
Neural development
Journal: Development
Development (2019) 146 (21): dev176461.
Published: 5 November 2019
... address: University of Milan, Department of Biosciences, Via G. Celoria 26, 20133, Milan, Italy. * Present address: The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. References Alto , L. T. and Terman , J. R. ( 2017 ). Semaphorins and their signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (1): 123–132.
Published: 1 January 2016
.... In search of additional cues that guide these axons to the CZ, we found that Semaphorin 3D (Sema3D) is expressed in the anterior bulb and acts as a repellent that pushes them towards the CZ. Further analysis indicates that Sema3D signaling is mediated through Nrp1a, while Nrp2b also promotes CZ targeting...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (17): 3292–3297.
Published: 1 September 2014
...Bart C. Jongbloets; R. Jeroen Pasterkamp Semaphorins are secreted and membrane-associated proteins that regulate many different developmental processes, including neural circuit assembly, bone formation and angiogenesis. Trans and cis interactions between semaphorins and their multimeric receptors...
Journal Articles
Journal: Development
Development (2014) 141 (12): 2473–2482.
Published: 15 June 2014
... proliferation is unknown. Here, we show that plexina2 (Plxna2), a member of a receptor family best known for its roles in axon and cell guidance, is required alongside the repellent semaphorin 6a (Sema6a) to keep cells integrated within the zebrafish eye vesicle epithelium. sema6a is expressed throughout...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (14): 2933–2941.
Published: 15 July 2013
... show in vivo that neuropilin-1 (Nrp1) and its co-receptor plexinA1 (Plxna1) are necessary to bias the extension of the dendrites of retinal ganglion cells to the apical side of the cell, and ectopically expressed class III semaphorins (Sema3s) disrupt this process. Importantly, the requirement for Nrp1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (19): 3633–3643.
Published: 1 October 2012
... for specifying accurate trajectories. We report here a novel mechanism by which ligand/receptor co-expression in neurons modulates the integration of other guidance cues by the growth cone. Class 3 semaphorins (Sema3 semaphorins) are chemotropic guidance cues for various neuronal projections, among which...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (16): 2978–2987.
Published: 15 August 2012
.... Disruption of hindbrain boundary cell formation alters the organisation of fgf20a -expressing neurons, consistent with a role of chemorepulsion from boundaries. The semaphorins Sema3fb and Sema3gb, which are expressed by boundary cells, and their receptor Nrp2a are required for clustering of fgf20a...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (18): 4085–4095.
Published: 15 September 2011
... M. , Taniguchi M. , Friedel R. H. , Rayburn H. , Tessier-Lavigne M. , Yoshida Y. , Okuno T. , et al . ( 2010 ). Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II . Nat. Immunol. 11 , 594 - 600 . Takazawa T...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (23): 3979–3989.
Published: 1 December 2009
... © 2009. 2009 Semaphorin Glomerular development Podocyte differentiation Endothelial cell migration Mouse Glomerulogenesis requires spatially directed cell migration, cell differentiation and modulation of cell-cell and cell-matrix interactions to generate the tri-layered structure...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (11): 1785–1789.
Published: 1 June 2009
... of the metameric somites, and PNS neurons and glia differentiate from neural crest cells (NCCs) that preferentially migrate into the anterior sclerotome halves. Previous analyses of mice deficient in the class 3 semaphorin (SEMA3)receptors neuropilin (NRP) 1 or 2 raised the possibility that each controlled...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (14): 2361–2371.
Published: 15 July 2008
.... A., Mashimo, H., Schoen, F. J. and Fishman, M. C. ( 1996 ). Semaphorin III is needed for normal patterning and growth of nerves, bones and heart. Nature 383 , 525 -528. Bizzoca, A., Virgintino, D., Lorusso, L., Buttiglione, M.,Yoshida, L., Polizzi, A., Tattoli, M., Cagiano, R., Rossi, F., Kozlov, S...
Journal Articles
Journal: Development
Development (2008) 135 (9): 1605–1613.
Published: 1 May 2008
...Quenten Schwarz; Joaquim M. Vieira; Beatrice Howard; Britta J. Eickholt; Christiana Ruhrberg Neuropilin (NRP) receptors and their class 3 semaphorin (SEMA3) ligands play well-established roles in axon guidance, with loss of NRP1, NRP2, SEMA3A or SEMA3F causing defasciculation and errors in growth...
Journal Articles
Journal: Development
Development (2007) 134 (24): 4491–4501.
Published: 15 December 2007
...Frédéric Moret; Christelle Renaudot; Muriel Bozon; Valérie Castellani Class III semaphorins (SemaIIIs) are intercellular cues secreted by surrounding tissues to guide migrating cells and axons in the developing organism. This chemotropic activity is crucial for the formation of nerves...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (22): 4063–4072.
Published: 15 November 2007
.... With these strains, the patterns of axonal projections of GC-D + neurons to necklace glomeruli can be visualized in whole mounts. We show that deficiency of one of the neuropilin 2 ligands of the class III semaphorin family, Sema3f, but not Sema3b, phenocopies the loss of neuropilin 2 (Nrp2) for axonal wiring of GC...
Journal Articles
Journal: Development
Development (2007) 134 (10): 1833–1843.
Published: 15 May 2007
... diverse ligands, the semaphorin SEMA3A and the VEGF164 isoform of vascular endothelial growth factor. SEMA3A was originally identified as a repulsive cue for developing axons that acts by signalling through receptor complexes containing NRP1 and plexins. In vitro, SEMA3A also inhibits integrin function...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (5): 857–865.
Published: 1 March 2007
... in differential target recognition are unknown. Prior to IPN innervation, we find that only the left habenula expresses the zebrafish homologue of Neuropilin1a (Nrp1a), a receptor for class III Semaphorins (Sema3s). Directional asymmetry of nrp1a expression relies on Nodal signaling and the presence of the left...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (20): 3983–3992.
Published: 15 October 2006
... transition (EMT) in order to migrate to target destinations where they differentiate. Here we report a role for a member of the semaphorin family of cell guidance molecules in NCC development. Morpholino-mediated knockdown of Sema3d inhibits the proliferation of hindbrain neuroepithelial cells. In addition...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (11): 2125–2135.
Published: 1 June 2006
...Joseph C. Ayoob; Jonathan R. Terman; Alex L. Kolodkin Plexin receptors play a crucial role in the transduction of axonal guidance events elicited by semaphorin proteins. In Drosophila , Plexin A(PlexA) is a receptor for the transmembrane semaphorin semaphorin-1a (Sema-1a)and is required for motor...
Journal Articles
Journal: Development
Development (2006) 133 (6): 1035–1044.
Published: 15 March 2006
... directing the midline crossing of contralateral axons, are still not well understood. Here we show that Sema3d,a secreted semaphorin expressed at the midline, guides the crossing of RGC axons in zebrafish. Both Sema3d knockdown and ubiquitous overexpression induced aberrant ipsilateral projections...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (4): 725–735.
Published: 15 February 2006
... optic commissure; black dots mark the position of the optic recess. * Corresponding author (e-mail: Karlstrom@bio.umass.edu ) 19 12 2005 © 2006. 2006 AC Chiasm Commissure Ephrin Gfap Glial bridge Morpholino Netrin POC Semaphorin Slit...