... for neuroendocrine neurons to migrate into the hypothalamus and release gonadotropins into the circulation. GnRH neuron Olfactory bulb Testes Axon guidance Plexin Semaphorin Hypogonadotropic hypogonadism Kallmann syndrome GnRH-secreting neurons are hypothalamic neuroendocrine cells that regulate...

.... In search of additional cues that guide these axons to the CZ, we found that Semaphorin 3D (Sema3D) is expressed in the anterior bulb and acts as a repellent that pushes them towards the CZ. Further analysis indicates that Sema3D signaling is mediated through Nrp1a, while Nrp2b also promotes CZ targeting...

...Bart C. Jongbloets; R. Jeroen Pasterkamp Semaphorins are secreted and membrane-associated proteins that regulate many different developmental processes, including neural circuit assembly, bone formation and angiogenesis. Trans and cis interactions between semaphorins and their multimeric receptors...

... proliferation is unknown. Here, we show that plexina2 (Plxna2), a member of a receptor family best known for its roles in axon and cell guidance, is required alongside the repellent semaphorin 6a (Sema6a) to keep cells integrated within the zebrafish eye vesicle epithelium. sema6a is expressed throughout...

... show in vivo that neuropilin-1 (Nrp1) and its co-receptor plexinA1 (Plxna1) are necessary to bias the extension of the dendrites of retinal ganglion cells to the apical side of the cell, and ectopically expressed class III semaphorins (Sema3s) disrupt this process. Importantly, the requirement for Nrp1...

... for specifying accurate trajectories. We report here a novel mechanism by which ligand/receptor co-expression in neurons modulates the integration of other guidance cues by the growth cone. Class 3 semaphorins (Sema3 semaphorins) are chemotropic guidance cues for various neuronal projections, among which...

.... Disruption of hindbrain boundary cell formation alters the organisation of fgf20a -expressing neurons, consistent with a role of chemorepulsion from boundaries. The semaphorins Sema3fb and Sema3gb, which are expressed by boundary cells, and their receptor Nrp2a are required for clustering of fgf20a...

... for correspondence ( yutaka.yoshida@cchmc.org ) * These authors contributed equally to this work Competing interests statement The authors declare no competing financial interests. 29 6 2011 © 2011. Semaphorin Plexin Spinal cord Synapse formation Oligodendrocyte...

... 2009. 2009 Semaphorin Glomerular development Podocyte differentiation Endothelial cell migration Mouse Glomerulogenesis requires spatially directed cell migration, cell differentiation and modulation of cell-cell and cell-matrix interactions to generate the tri-layered structure...

... of the metameric somites, and PNS neurons and glia differentiate from neural crest cells (NCCs) that preferentially migrate into the anterior sclerotome halves. Previous analyses of mice deficient in the class 3 semaphorin (SEMA3)receptors neuropilin (NRP) 1 or 2 raised the possibility that each controlled...

... to this work 15 5 2008 © 2008. 2008 Axon guidance Endocytosis Neural cell-adhesion molecule Semaphorin Sensory neurons Mouse Cntn2 Somatosensory neurons located in the mammalian dorsal root ganglion (DRG)comprise a number of different subclasses defined by the sensory...

...Quenten Schwarz; Joaquim M. Vieira; Beatrice Howard; Britta J. Eickholt; Christiana Ruhrberg Neuropilin (NRP) receptors and their class 3 semaphorin (SEMA3) ligands play well-established roles in axon guidance, with loss of NRP1, NRP2, SEMA3A or SEMA3F causing defasciculation and errors in growth...

...Frédéric Moret; Christelle Renaudot; Muriel Bozon; Valérie Castellani Class III semaphorins (SemaIIIs) are intercellular cues secreted by surrounding tissues to guide migrating cells and axons in the developing organism. This chemotropic activity is crucial for the formation of nerves...

.... With these strains, the patterns of axonal projections of GC-D + neurons to necklace glomeruli can be visualized in whole mounts. We show that deficiency of one of the neuropilin 2 ligands of the class III semaphorin family, Sema3f, but not Sema3b, phenocopies the loss of neuropilin 2 (Nrp2) for axonal wiring of GC...

... diverse ligands, the semaphorin SEMA3A and the VEGF164 isoform of vascular endothelial growth factor. SEMA3A was originally identified as a repulsive cue for developing axons that acts by signalling through receptor complexes containing NRP1 and plexins. In vitro, SEMA3A also inhibits integrin function...

... in differential target recognition are unknown. Prior to IPN innervation, we find that only the left habenula expresses the zebrafish homologue of Neuropilin1a (Nrp1a), a receptor for class III Semaphorins (Sema3s). Directional asymmetry of nrp1a expression relies on Nodal signaling and the presence of the left...

... transition (EMT) in order to migrate to target destinations where they differentiate. Here we report a role for a member of the semaphorin family of cell guidance molecules in NCC development. Morpholino-mediated knockdown of Sema3d inhibits the proliferation of hindbrain neuroepithelial cells. In addition...

...Joseph C. Ayoob; Jonathan R. Terman; Alex L. Kolodkin Plexin receptors play a crucial role in the transduction of axonal guidance events elicited by semaphorin proteins. In Drosophila , Plexin A(PlexA) is a receptor for the transmembrane semaphorin semaphorin-1a (Sema-1a)and is required for motor...

... directing the midline crossing of contralateral axons, are still not well understood. Here we show that Sema3d,a secreted semaphorin expressed at the midline, guides the crossing of RGC axons in zebrafish. Both Sema3d knockdown and ubiquitous overexpression induced aberrant ipsilateral projections...

... Morpholino Netrin POC Semaphorin Slit The anterior commissure (AC), post-optic commissure (POC) and the optic chiasm are the first major axon pathways to cross the midline of the vertebrate forebrain during embryonic development. The POC is formed as neurons in the lateral diencephalon...