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Keywords: Self-renewal
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Journal Articles
Journal: Development
Development (2022) 149 (24): dev200988.
Published: 21 December 2022
...Anish Dattani; Tao Huang; Corin Liddle; Austin Smith; Ge Guo ABSTRACT Propagation of human naïve pluripotent stem cells (nPSCs) relies on the inhibition of MEK/ERK signalling. However, MEK/ERK inhibition also promotes differentiation into trophectoderm (TE). Therefore, robust self-renewal requires...
Includes: Supplementary data
Journal Articles
Journal: Development
Series: REVIEW COMMONS TRANSFER
Development (2022) 149 (19): dev200986.
Published: 3 October 2022
... of nephron progenitors during renal development. Organogenesis Tissue-specific progenitors Pycr1/Pycr2 Self-renewal Differentiation Development Metabolism Receptor tyrosine kinase signaling Intracellular signaling cascades Academy of Finland http://dx.doi.org/10.13039/501100002341...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (13): dev200171.
Published: 6 July 2022
... to study lineage specification of placental tissues; however, the regulatory network controlling self-renewal remains elusive. Here, we present a single-cell atlas of human trophoblast development from zygote to mid-gestation together with single-cell profiling of hTSCs. We determine the transcriptional...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2021) 148 (11): dev194399.
Published: 8 June 2021
... show that a self-renewing cell type – if defined as suggested by this framework – must reside at the top of any homeostatic renewing lineage hierarchy, and only there. This architecture arises as a natural consequence of homeostasis, and indeed is the only possible way that lineage architectures can...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (6): dev173146.
Published: 26 March 2019
... propagation. Differentiation Embryonic stem cells Pluripotency Self-renewal Summary: Detailed protocols for the propagation, manipulation and differentiation of mouse embryonic stem cells, with tips for minimising variability and improving the efficiency, reproducibility and reliability...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (4): dev156059.
Published: 18 February 2019
..., are generated. Recent studies have significantly modified earlier views on the mechanisms of NSC self-renewal and neurogenesis in the adult brain. Here, we discuss the molecular control, heterogeneity, regional specification and cell division modes of V-SVZ NSCs, and draw comparisons with NSCs in the SGZ. We...
Journal Articles
Journal Articles
Journal: Development
Development (2017) 144 (2): 235–247.
Published: 15 January 2017
... for myogenic commitment and differentiation, timely repression of their activity is necessary for the self-renewal and maintenance of muscle stem cells (satellite cells). Here, we define Ascl2 as a novel inhibitor of MRFs. During mouse development, Ascl2 is transiently detected in a subpopulation of Pax7...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2016) 143 (17): 3097–3108.
Published: 1 September 2016
... that facilitates the membrane localization of GLP-1 /Notch. Self-renewal Differentiation STRIPAK Far complex Germ cells Endoplasmic reticulum (ER) is the site of synthesis and folding of all secreted and transmembrane proteins, including the ligands and receptors of some key signaling pathways...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (16): 2930–2945.
Published: 15 August 2016
...Jun Yu; Xiang Lan; Xia Chen; Chao Yu; Yiwen Xu; Yujuan Liu; Lingna Xu; Heng-Yu Fan; Chao Tong The homeostasis of self-renewal and differentiation in stem cells is controlled by intrinsic signals and their niche. We conducted a large-scale RNA interference (RNAi) screen in Drosophila testes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (4): 575–581.
Published: 15 February 2016
... fate decision Stem cell Self-renewal Differentiation Whereas differential exposure to environmental cues can instruct asymmetric fates, varying mitotic spindle orientation can produce intrinsically asymmetric cell divisions by segregating fate determinants unequally in the daughter cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (9): 1572–1581.
Published: 1 May 2015
... re-enter the cell cycle to proliferate and subsequently exit the cell cycle to differentiate or self-renew. Recent studies have demonstrated that satellite cells are heterogeneous and that subpopulations of satellite stem cells are able to perform asymmetric divisions to generate myogenic progenitors...
Journal Articles
Journal: Development
Development (2015) 142 (7): 1228–1241.
Published: 1 April 2015
...Yuwen Li; Jiao Liu; Wencheng Li; Aaron Brown; Melody Baddoo; Marilyn Li; Thomas Carroll; Leif Oxburgh; Yumei Feng; Zubaida Saifudeen Contrary to its classic role in restraining cell proliferation, we demonstrate here a divergent function of p53 in the maintenance of self-renewal of the nephron...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2014) 141 (24): 4697–4709.
Published: 15 December 2014
...Chen-yan Ma; Mao-jin Yao; Qi-wei Zhai; Jian-wei Jiao; Xiao-bing Yuan; Mu-ming Poo The balance between self-renewal and differentiation of adult neural stem cells (aNSCs) is essential for the maintenance of the aNSC reservoir and the continuous supply of new neurons, but how this balance is fine...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (21): 4087–4097.
Published: 1 November 2014
...Sowmya Parameswaran; Xiaohuan Xia; Ganapati Hegde; Iqbal Ahmad In vertebrate retina, histogenesis occurs over an extended period. To sustain the temporal generation of diverse cell types, retinal progenitor cells (RPCs) must self-renew. However, self-renewal and regulation of RPCs remain poorly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (8): 1649–1659.
Published: 15 April 2014
... and differentiation of LRCs in vitro and impaired satellite cell self-renewal after muscle injury. By contrast, loss of p21 cip1 only affected nonLRCs, in which myogenic commitment was inhibited. Our results provide evidence that restriction of self-renewal potential to LRCs is established early in life...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (20): 4155–4164.
Published: 15 October 2013
... cell self-renewal and differentiation; they divide asymmetrically to self-renew and generate the neurons and glia of the CNS. Here we report the identification of midlife crisis ( mdlc ; CG4973 ) as a gene required for the maintenance of neuronal differentiation and for neuroblast proliferation...
Includes: Supplementary data