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Keywords: Self-organization
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Journal Articles
Journal: Development
Development (2023) 150 (3): dev200851.
Published: 31 January 2023
...Pierre-Yves Gires; Mithun Thampi; Sebastian W. Krauss; Matthias Weiss ABSTRACT Self-organization of cells into higher-order structures is key for multicellular organisms, for example via repetitive replication of template-like founder cells or syncytial energids. Yet, very similar spatial...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (16): dev199672.
Published: 23 August 2021
... of new therapies is lagging compared with other fields. One major bottleneck hindering progress is the lack of self-organizing human cardiac models that recapitulate key aspects of human heart development, physiology and disease. Current in vitro cardiac three-dimensional systems are either engineered...
Journal Articles
Journal: Development
Development (2021) 148 (14): dev193268.
Published: 19 July 2021
... development and tissue homeostasis are similar, and that interactions between these disciplines will be beneficial for both research fields. Embryonic development Patterning Self-organization Signalling Stem cell control Tissue homeostasis European Research Council http://dx.doi.org...
Journal Articles
Journal: Development
Development (2021) 148 (7): dev199133.
Published: 15 April 2021
..., revealing a modular organization in which progenitor differentiation and neurogenesis are self-organized and highly regulated. Our findings position Igf signaling as a key module for controlling retinal size and composition, with important evolutionary implications. * Present address: Research...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2019) 146 (14): dev175430.
Published: 25 July 2019
... of dorsal spinal cell types in mouse and human pluripotent stem cell-derived organoids. Bone morphogenetic proteins Patterning Organoid Relay and associating spinal dorsal interneurons Pluripotent stem cells differentiation Self-organization The rise of methods to generate pluripotent...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (4): dev156836.
Published: 14 February 2018
... cells, and the posterior-anterior axis is self-organized as the central-peripheral axis. This method is applicable to chemical-library screening and will facilitate the analysis of the molecular nature of the segmentation clock. References Aulehla , A. , Wehrle , C. , Brand-Saberi , B...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (7): 1261–1272.
Published: 1 April 2017
... a myofibrillogenesis model in which mechanical tension and spontaneous muscle twitching synchronize the simultaneous self-organization of different sarcomeric protein complexes to build highly regular cross-striated myofibrils spanning the length of large muscle fibers. * These authors contributed equally...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (7): 1211–1220.
Published: 1 April 2017
..., the molecular mechanisms that are essential for thalamic differentiation are still unknown. Here, we have succeeded in generating thalamic neurons from mouse embryonic stem cells (mESCs) by modifying the default method that induces the most-anterior neural type in self-organizing culture. A low concentration...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (6): 976–985.
Published: 15 March 2017
...Mijo Simunovic; Ali H. Brivanlou ABSTRACT Cells have an intrinsic ability to self-assemble and self-organize into complex and functional tissues and organs. By taking advantage of this ability, embryoids, organoids and gastruloids have recently been generated in vitro , providing a unique...
Journal Articles
Journal: Development
Development (2016) 143 (19): 3514–3521.
Published: 1 October 2016
...Joseph Pickering; Matthew Towers In an influential model of pattern formation, a gradient of Sonic hedgehog (Shh) signalling in the chick wing bud specifies cells with three antero-posterior positional values, which give rise to three morphologically different digits by a self-organizing mechanism...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (14): 2745–2749.
Published: 15 July 2014
...Daniel Goldman The RIKEN Center for Developmental Biology in Kobe, Japan, hosted a meeting entitled ‘Regeneration of Organs: Programming and Self-Organization’ in March, 2014. Scientists from across the globe met to discuss current research on regeneration, organ morphogenesis and self-organization...
Journal Articles
Journal: Development
Development (2007) 134 (19): 3539–3548.
Published: 1 October 2007
... initiation. We propose that de novo shoot meristem induction is an easily accessible system for the study of patterning and self-organization in the well-studied model organism Arabidopsis . * Author for correspondence (e-mail: meyerow@caltech.edu ) 21 7 2007 © 2007. 2007 Auxin...
Includes: Supplementary data