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Keywords: Scleraxis
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Journal Articles
Journal: Development
Development (2020) 147 (12): dev185389.
Published: 24 June 2020
... progenitors through the Ets transcription factors Pea3 and Erm to regulate scleraxis expression . Development   131 , 3885 - 3896 . 10.1242/dev.01275 Brent , A. E. , Schweitzer , R. and Tabin , C. J. ( 2003 ). A somitic compartment of tendon progenitors . Cell   113 , 235 - 248...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (9): dev186239.
Published: 12 May 2020
... sternum ossification at the boundary of the lateral and somitic mesoderm. Pre-osteoblast Sternum Fibroblast Runx2 Scleraxis Lateral plate mesenchyme cells The sternum protects the heart and lungs in vertebrates and constitutes the most ventral part of the thoracic skeleton. The sternum...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev182782.
Published: 4 October 2019
...Alice H. Huang; Spencer S. Watson; Lingyan Wang; Brendon M. Baker; Haruhiko Akiyama; John V. Brigande; Ronen Schweitzer ABSTRACT The transcription factor scleraxis ( Scx ) is required for tendon development; however, the function of Scx is not fully understood. Although Scx is expressed by all...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (14): dev167882.
Published: 26 July 2019
... Article: The development of protrusions, such as eminences and condyles, along long bones in mice is coordinated by a patterning mechanism involving global and regional genetic regulation. Cartilage Patterning Morphology Superstructure Sox9 Scleraxis Modularity Gli3 Pbx Hox Mouse...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (4): dev167452.
Published: 28 February 2019
.... Sesamoid bone Joint Sox9 Scleraxis Tgfβ BMP Mouse Sesamoid bones constitute a special group of bones that are integral to the skeletons of many vertebrate species ( Abdala et al., 2017 ; Bizarro, 1921 ; Corina Vera et al., 2015 ; Jerez et al., 2009 ; Maisano, 2002 ; Ponssa et al., 2010...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (20): 3839–3851.
Published: 15 October 2016
... tendon formation. Chick Limb Tendon Mechanobiology Scleraxis Tendon is a connective tissue that transmits the forces generated by muscle to bone and allows body motion. Type I collagen is the main structural and functional component of tendons. The signals regulating the production...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (10): 1831–1839.
Published: 15 May 2015
... - 431 . Schweitzer , R. , Chyung , J. H. , Murtaugh , L. C. , Brent , A. E. , Rosen , V. , Olson , E. N. , Lassar , A. and Tabin , C. J. ( 2001 ). Analysis of the tendon cell fate using Scleraxis, a specific marker for tendons and ligaments . Development 128...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (4): 787–796.
Published: 15 February 2015
... that scleraxis (Scx) and osterix (Osx) antagonistically regulate tensile force-responsive PDL fibrogenesis and osteogenesis. In the developing PDL, Scx was induced during tooth eruption and co-expressed with Osx. Scx was highly expressed in elongated fibroblastic cells aligned along collagen fibers, whereas Osx...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (19): 3683–3696.
Published: 1 October 2014
... identified. We have undertaken a transcriptome analysis of mouse limb tendon cells that were isolated at different stages of development based on scleraxis ( Scx ) expression. Microarray comparisons allowed us to establish a list of genes regulated in tendon cells during mouse limb development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (5): 791–801.
Published: 1 March 2009
.... In order to identify the molecular mechanisms that control the differentiation of the visceral mesenchyme into SMCs in the vertebrate stomach, we developed microarrays to analyze the gene expression profiles of undifferentiated and differentiated avian stomachs. We identify Scleraxis , a basic-helix-loop...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (14): 2697–2708.
Published: 15 July 2007
...Nicholas D. Murchison; Brian A. Price; David A. Conner; Douglas R. Keene; Eric N. Olson; Clifford J. Tabin; Ronen Schweitzer The scleraxis ( Scx ) gene, encoding a bHLH transcription factor, is expressed in the progenitors and cells of all tendon tissues. To determine Scx function, we produced...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (6): 1305–1314.
Published: 15 March 2005
... extensively. By contrast,the interactions between cells from different regions within the somite are less well characterised. Here, we demonstrate that myotomally derived FGFs act through the MAPK signal transduction cascade and in particular, ERK1/2 to activate scleraxis expression in a population...
Journal Articles
Journal: Development
Development (2005) 132 (3): 515–528.
Published: 1 February 2005
... for correspondence (e-mail: tabin@genetics.med.harvard.edu ) 26 11 2004 ©2005. 2005 Somite Syndetome Sclerotome Myotome Tendon Scleraxis Myf5 Myod1 ( MyoD ) Sox5 Sox6 FGF Mouse We next looked at formation of the mature axial tendons in Sox5 -/- ; Sox6 -/- double...
Journal Articles
Journal: Development
Development (2004) 131 (16): 3885–3896.
Published: 15 August 2004
...Ava E. Brent; Clifford J. Tabin During somite development, a fibroblast growth factor (FGF) signal secreted from the myotome induces formation of a scleraxis ( Scx )-expressing tendon progenitor population in the sclerotome, at the juncture between the future lineages of muscle and cartilage. While...
Journal Articles
Journal: Development
Development (2001) 128 (19): 3855–3866.
Published: 1 October 2001
...Ronen Schweitzer; Jay H. Chyung; Lewis C. Murtaugh; Ava E. Brent; Vicki Rosen; Eric N. Olson; Andrew Lassar; Clifford J. Tabin Little is known about the genesis and patterning of tendons and other connective tissues, mostly owing to the absence of early markers. We have found that Scleraxis, a bHLH...