... (SSCs) was not affected. Furthermore, our molecular analyses identified that CK1α loss was accompanied by nuclear stability of p53 protein in mouse spermatogonia, and dual-luciferase reporter and chromatin immunoprecipitation assays revealed that p53 directly targeted the Sox3 gene. In addition, the p53...

... that the transcription factor Sox3 represses multiple steps in the signalling events that lead to organizer formation. Although β-catenin, Bozozok and Squint are known to play major roles in establishing the dorsal organizer in vertebrate embryos, overexpression of any of these is insufficient to induce robust...

... 28 9 2004 © 2004. 2004 Pre-placodal ectoderm Neural crest foxD3 zic2 sox2 sox3 keratin dlx5 dlx6 Cell fate determination Patterning Xenopus It was discovered over a century ago that the cranial sensory organs of vertebrates arise from discrete areas...

... to its competition with β-catenin-regulated TCF-type transcription factors for specific DNA binding sites, but rather to SOX3 binding to sites within the promoter of the early VegT- andβ-catenin-regulated dorsal-mesoderm-inducing gene Xnr5 . Although B1-type SOX proteins, such as XSOX3, are commonly...