... pop-1 , support the model that POP-1 TCF induces differentiation at a high nuclear level, whereas low nuclear POP-1 promotes seam cell self-renewal. Before symmetric division, the transcriptional regulator RNT-1 Runx and cofactor BRO-1 CBFβ temporarily bypass Wnt/β-catenin asymmetry by downregulating...

...Renaud Mevel; Julia E. Draper; Michael Lie-a-Ling; Valerie Kouskoff; Georges Lacaud ABSTRACT RUNX transcription factors orchestrate many different aspects of biology, including basic cellular and developmental processes, stem cell biology and tumorigenesis. In this Primer, we introduce...

..., the genetic pathway regulating sternal development remains obscure. In this paper we identified a distinct role of the Runx family in sternal development. Interestingly, it has previously been reported that mesenchymal-specific Sox9 -deficient mice ( Prx1 Cre/ Sox9 f/ f mice) completely lack the sternum...

... deficiency. † Author for correspondence (e-mail: tshiga@md.tsukuba.ac.jp ) * These authors contributed equally to this work 3 3 2008 © 2008. 2008 Runx Transcription factor Dorsal root ganglion Proprioceptive neuron TrkC (Ntrk3) TrkA (Ntrk1) Parvalbumin Cell fate...

... of the mammalian CBFβ-interacting Runx factors), caused by failed cell divisions in the seam lineages. Our studies indicate that BRO-1 and RNT-1 form a cell proliferation-promoting complex, and that BRO-1 increases both the affinity and specificity of RNT-1-DNA interactions. Overexpression of bro-1 ,like rnt-1...

... (GCM) and GCM2 control plasmatocyte development, whereas the RUNX factor Lozenge (LZ) is required for crystal cell differentiation. We have investigated the segregation process that leads to the formation of these two cell types, and the interplay between LZ and GCM/GCM2. We show that,surprisingly, gcm...

... for the Runx protein Lozenge ( Canon and Banerjee,2003 ). In this case, the presence of binding sites for the Cut homeodomain protein helps to stabilize a complex that leads to repression of deadpan transcription in the same cells in which Lozenge is responsible for activation of Drosophila Pax2...

... lozenge runt Runx Eye development Ommatidium CBFβ RNAi A fundamental problem in biology is determining how different cell types are specified during the development of a multicellular organism. This process is usually initiated by extracellular cues that activate signal transduction...