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Keywords: Roof plate
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Journal Articles
Journal: Development
Development (2019) 146 (2): dev159343.
Published: 16 January 2019
..., the effects of morphological changes on intercellular signaling remain to be fully elucidated. In this study, we examined the effect of morphological changes in Wnt-producing cells on intercellular signaling in the spinal cord. After mid-gestation, roof-plate cells stretched along the dorsoventral axis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (11): 2269–2279.
Published: 1 June 2013
.... Patterns 4 , 35 - 46 . Levy C. , Khaled M. , Fisher D. E. ( 2006 ). MITF: master regulator of melanocyte development and melanoma oncogene . Trends Mol. Med. 12 , 406 - 414 . Liem K. F. Jr , Tremml G. , Jessell T. M. ( 1997 ). A role for the roof plate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (3): 507–518.
Published: 1 February 2010
... activity is directed dorsally to the roof plate and dorsal-most (dI1) interneurons through predicted Tcf- and Cdx-homeodomain binding sites and is repressed ventrally via predicted Tgif homeobox and ventral Lim-homeodomain binding sites. Raldh2 and Math1/Cath1 expression in mouse and chicken highlights...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (5): 889–898.
Published: 1 March 2008
... that it fails to develop because reducing FGF signaling perturbs the balance between vermis and roof plate development in rhombomere 1. We suggest a molecular explanation for this phenomenon by providing evidence that FGF signaling functions to inhibit the BMP signaling that promotes roof plate development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (19): 3449–3460.
Published: 1 October 2007
...Nina L. Hunter; Susan M. Dymecki Both hindbrain roof plate epithelium (hRPe) and hindbrain choroid plexus epithelium (hCPe) produce morphogens and growth factors essential for proper hindbrain development. Despite their importance, little is known about how these essential structures develop...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (15): 2793–2804.
Published: 1 August 2006
... of the neural tube. Mechanisms specifying distinct populations within the early cerebellar anlage are less defined. Using a newly developed gene expression map of the early cerebellar anlage, we demonstrate that secreted signals from the rhombomere 1 roof plate are both necessary and sufficient...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (15): 2905–2913.
Published: 1 August 2006
...Paula Alexandre; Isabelle Bachy; Morgane Marcou; Marion Wassef The roof plate (RP) of the midbrain shows an unusual plasticity, as it is duplicated or interrupted by experimental manipulations involving the mid/hindbrain organizer or FGF8. In previous experiments, we have found that FGF8 induces...
Journal Articles
Journal: Development
Development (2006) 133 (13): 2467–2476.
Published: 1 July 2006
...@virus.kyoto-u.ac.jp ) * Present address: Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan 12 4 2006 © 2006. 2006 bHLH Floor plate Isthmus Rhombomere boundary Roof plate Zona limitans intrathalamica Mouse The developing...
Journal Articles
Journal: Development
Development (2005) 132 (15): 3549–3559.
Published: 1 August 2005
... depends on DM cells in a non-cell-autonomous fashion. References Alexandre, P. and Wassef, M. ( 2003 ). The isthmic organizer links anteroposterior and dorsoventral patterning in the mid/hindbrain by generating roof plate structures. Development 130 , 5331 -5338. Awatramani, R., Soriano, P...
Journal Articles
Journal: Development
Development (2004) 131 (11): 2693–2705.
Published: 1 June 2004
...Victor V. Chizhikov; Kathleen J. Millen Numerous studies have identified the roof plate as an embryonic signaling center critical for dorsal central nervous system patterning, but little is known about mechanisms that control its formation and its separation from clonally related neural crest cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (5): 1017–1028.
Published: 1 March 2004
...Ying Liu; Amy W. Helms; Jane E. Johnson Patterning of the dorsal neural tube involves Bmp signaling, which results in activation of multiple pathways leading to the formation of neural crest,roof plate and dorsal interneuron cell types. We show that constitutive activation of Bmp signaling at early...
Journal Articles
Journal: Development
Development (2003) 130 (23): 5649–5661.
Published: 1 December 2003
..., is required for the migration of cells forming the roof plate of the neural tube and, subsequently, for neural crest migration. These cells are properly determined but remain at their site of origin. Consistent with a possible role in cell movement, Vg1 RBP asymmetrically localizes to extended processes...
Journal Articles
Journal: Development
Development (2003) 130 (22): 5319–5330.
Published: 15 November 2003
... domain located at the mid/hindbrain boundary produce the roof plate of the mid/hindbrain domain. Cells migrating anteriorly from this region populate the caudal midbrain roof plate whereas cells migrating posteriorly populate the cerebellar roof plate. In addition, the adjacent paramedial isthmic...
Journal Articles
Journal: Development
Development (2003) 130 (22): 5331–5338.
Published: 15 November 2003
... of transplantation and ablation experiments in avian embryos, we show here that, in the caudal midbrain, a restricted dorsal domain of the isthmic organizer, that we call the isthmic node, is both necessary and sufficient for the formation and positioning of the roof plate, a signaling structure that marks...
Journal Articles
Journal: Development
Development (2003) 130 (17): 4025–4036.
Published: 1 September 2003
... the effects of Msx1 loss of function in the developing central nervous system. In the mouse, all three Msx genes( Msx1, Msx2 and Msx3 ) are expressed in the dorsal midline of the neural tube ( Robert et al.,1989 ; Catron et al.,1996 ; Shimeld et al.,1996 ; Wang et al.,1996 ). A normal roof plate fails...
Journal Articles
Journal: Development
Development (2002) 129 (4): 983–991.
Published: 15 February 2002
... by expression of dopamine-β-hydroxylase and tyrosine hydroxylase. Bmp5 is expressed in the dorsal neuroepithelium in proximity to Phox2 -expressing cells. BMP inhibition in stage 10 chick embryos resulted in the lack of LC neurones or in their generation at the dorsal midline, and loss of roof plate and rhombic...