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Keywords: Rho
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Journal Articles
Journal: Development
Development (2024) 151 (3): dev202123.
Published: 7 February 2024
... contractility. Consistent with this, active RhoA was detected throughout these fibers. Given that FGF promotes fiber elongation, we propose that it does so through regulation of Rho activity. * Author for correspondence ( yuki.sugiyama@sydney.edu.au ) Handling Editor: Thomas Lecuit Competing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (21): 3957–3967.
Published: 1 November 2017
... is differentially regulated in ICM and TE cells is poorly understood. Through an inhibitor/activator screen, we have identified Rho as a negative regulator of Hippo in TE cells, and PKA as a positive regulator of Hippo in ICM cells. We further elucidated a novel mechanism by which Rho suppresses Hippo, distinct...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (11): 1937–1947.
Published: 1 June 2017
... differentiation requires dynamic interactions with somatic escort cells. This involves a complex meshwork of escort cell protrusions and is regulated by multiple signalling pathways. Germline stem cells Escort cells Drosophila Stat Erk Rho Cdc42 Protrusion Balancing stem cell maintenance...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (1): 151–161.
Published: 1 January 2006
..., smooth muscle or stroma in addition to epithelia of glomerulus and renal tubules. * Author for correspondence (e-mail: ryuichi@kaiju.medic.kumamoto-u.ac.jp ) 24 10 2005 © 2006. 2006 Progenitor Kidney Colony-forming assay Sall1 Wnt PCP JNK Rho Mouse...
Journal Articles
Journal: Development
Development (2004) 131 (20): 5053–5063.
Published: 15 October 2004
... is required for cytokinesis in every tissue examined, with mutant cells exhibiting multinucleate and hyperploid phenotypes. Strong genetic interactions were observed between citron and pbl alleles and constructs. Vertebrate studies implicate at least two Rho effector kinases, Citron and Rok, in cytokinesis...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (11): 2641–2651.
Published: 1 June 2004
...Masha Smallhorn; Michael J. Murray; Robert Saint Drosophila pebble ( pbl ) encodes a Rho-family GTP exchange factor (GEF) required for cytokinesis. The accumulation of high levels of PBL protein during interphase and the developmentally regulated expression of pbl in mesodermal tissues suggested...
Journal Articles
Journal: Development
Development (2003) 130 (9): 1825–1835.
Published: 1 May 2003
... in exploring the extracellular surroundings with filopodia-like Actin containing projections. We hypothesized that the small GTPases Rho, Rac and Cdc42 are involved in Actin cytoskeletal rearrangements that underlie peripheral glial migration and nerve ensheathement. To test this, transgenic forms...
Journal Articles
Journal: Development
Development (2003) 130 (4): 671–681.
Published: 15 February 2003
... balance of myosin II activity modulated through the phosphorylation state of its regulatory light chain. To assess the relationship between DMYPT regulation of myosin II and signaling via the Rho GTPase family members, we turned to the Drosophila eye where sensitive genetic interactions can...
Journal Articles
Journal: Development
Development (2002) 129 (5): 1215–1223.
Published: 1 March 2002
... cell shape change. Aberrant accumulation of F-actin within the leading edge cells may correspond to the morphological aberrations of such cells. Similar defects were seen in embryos overexpressing Rho-kinase, suggesting that myosin phosphatase and Rho-kinase function antagonistically. The genetic...
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (1999) 126 (23): 5267–5274.
Published: 1 December 1999
... binds to actin in the interaction trap system and in vitro. In addition, SPIRE interacts with the rho family GTPases RHOA, RAC1 and CDC42 in the interaction trap system. Thus, our evidence supports the model that SPIRE links rho family signaling to the actin cytoskeleton. * Author...
Journal Articles
Journal: Development
Development (1999) 126 (23): 5339–5351.
Published: 1 December 1999
...Katrin Wünnenberg-Stapleton; Ira L. Blitz; Chikara Hashimoto; Ken W. Y. Cho The Rho family of small GTPases regulates a variety of cellular functions, including the dynamics of the actin cytoskeleton, cell adhesion, transcription, cell growth and membrane trafficking. We have isolated the first...
Journal Articles
Journal: Development
Development (1998) 125 (24): 5055–5067.
Published: 15 December 1998
... of neural crest differentiation, we performed a PCR-based screen for genes induced by BMPs in chick neural plate cells. We describe the cloning and characterization of one gene obtained from this screen, rhoB , a member of the rho family GTP-binding proteins. rhoB is expressed in the dorsal neural tube...