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Keywords: Rho
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Journal Articles
Journal: Development
Development (2017) 144 (21): 3957–3967.
Published: 1 November 2017
... is differentially regulated in ICM and TE cells is poorly understood. Through an inhibitor/activator screen, we have identified Rho as a negative regulator of Hippo in TE cells, and PKA as a positive regulator of Hippo in ICM cells. We further elucidated a novel mechanism by which Rho suppresses Hippo, distinct...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (11): 1937–1947.
Published: 1 June 2017
... differentiation requires dynamic interactions with somatic escort cells. This involves a complex meshwork of escort cell protrusions and is regulated by multiple signalling pathways. Germline stem cells Escort cells Drosophila Stat Erk Rho Cdc42 Protrusion Balancing stem cell maintenance...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (1): 151–161.
Published: 1 January 2006
... kidney, can be used for examining mechanisms of renal progenitor differentiation. 24 10 2005 © 2006. 2006 Progenitor Kidney Colony-forming assay Sall1 Wnt PCP JNK Rho Mouse Mammalian adult kidney, metanephros, is formed by reciprocally inductive...
Journal Articles
Journal: Development
Development (2004) 131 (20): 5053–5063.
Published: 15 October 2004
... is required for cytokinesis in every tissue examined, with mutant cells exhibiting multinucleate and hyperploid phenotypes. Strong genetic interactions were observed between citron and pbl alleles and constructs. Vertebrate studies implicate at least two Rho effector kinases, Citron and Rok, in cytokinesis...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (11): 2641–2651.
Published: 1 June 2004
...Masha Smallhorn; Michael J. Murray; Robert Saint Drosophila pebble ( pbl ) encodes a Rho-family GTP exchange factor (GEF) required for cytokinesis. The accumulation of high levels of PBL protein during interphase and the developmentally regulated expression of pbl in mesodermal tissues suggested...
Journal Articles
Journal: Development
Development (2003) 130 (9): 1825–1835.
Published: 1 May 2003
... in exploring the extracellular surroundings with filopodia-like Actin containing projections. We hypothesized that the small GTPases Rho, Rac and Cdc42 are involved in Actin cytoskeletal rearrangements that underlie peripheral glial migration and nerve ensheathement. To test this, transgenic forms...
Journal Articles
Journal: Development
Development (2003) 130 (4): 671–681.
Published: 15 February 2003
... is necessary for cell movement, but strong adhesion inhibits cell movement. * Author for correspondence (e-mail: perrimon@rascal.med.harvard.edu ) 21 11 2002 © 2003. 2003 Rac Rho Rho kinase Myosin II Myosin phosphatase zipper spaghetti-squash MYPT Dorsal closure Ring...
Journal Articles
Journal: Development
Development (2002) 129 (5): 1215–1223.
Published: 1 March 2002
... cell shape change. Aberrant accumulation of F-actin within the leading edge cells may correspond to the morphological aberrations of such cells. Similar defects were seen in embryos overexpressing Rho-kinase, suggesting that myosin phosphatase and Rho-kinase function antagonistically. The genetic...