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Keywords: Retroviral insertional mutagenesis
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Journal Articles
Journal: Development
Development (2003) 130 (7): 1367–1379.
Published: 1 April 2003
... to be essential for normal head development by targeted gene disruption in mice. However, studies using such knockout techniques are limited to known genes. Through retroviral insertional mutagenesis and genetic screening approaches, we have identified a null-mutant mouse strain with complete forebrain truncation...