... , F. , Liao , Y. et al. ( 2013 ). Retinoid signaling in progenitors controls specification and regeneration of the urothelium . Dev. Cell 26 , 469 - 482 . 10.1016/j.devcel.2013.07.017 Georgas , K. M. , Armstrong , J. , Keast , J. R. , Larkins , C. E. , McHugh...

.... * Authors for correspondence ( rhinn@igbmc.fr ; dolle@igbmc.fr ) Competing interests statement The authors declare no competing financial interests. © 2012. Retinoids Retinoic acid Retinol dehydrogenase (RDH) Retinaldehyde dehydrogenase (RALDH) CYP26 Hindbrain Forebrain...

... Retinoids Hydronephrosis Lower urinary tract Mouse The mature urinary tract consists of kidneys that filter and regulate blood homeostasis, the bladder and urethra that store and excrete urine, and the ureters that conduct urine from the kidneys to the bladder. The upper (kidney and ureter...

... the anterior presomitic mesoderm (PSM) and the somites attenuates Fgf signalling and allows neural progenitors to initiate differentiation. A recent study implicated canonical Wnt signalling in mediating the transition from Fgf to retinoid activity ( Olivera-Martinez and Storey, 2007 ). The acquisition...

...: Department of Pharmacology, Weill Medical College of Cornell University, 1300 York Avenue, Box 70, New York, NY 10065, USA 7 11 2008 © 2009. 2009 Retinoids Nolz1 Grg5 Motoneuron Identity Repressor The establishment of a functional nervous system depends upon the coordinated...

... ) * These authors contributed equally to this work 9 11 2005 © 2006. 2006 Retinoids Forebrain development Eye development Neural crest Telencephalon Diencephalon Optic vesicle Pituitary Sonic hedgehog FGF Mouse Aldh1a2 The embryonic forebrain...

... of the diffusible mesodermal signals that pattern the pharyngeal endoderm. * Author for correspondence (e-mail: dolle@igbmc.u-strasbg.fr ) 24 2 2003 © 2003. 2003 Retinoids Branchial arches Pharyngeal endoderm DiGeorge syndrome Hirschprung's disease Mouse mutant Conotruncal...

...Aida Halilagic; Maija H. Zile; Michèle Studer Retinoids, and in particular retinoic acid (RA), are known to induce posterior fates in neural tissue. However, alterations in retinoid signalling dramatically affect anterior development. Previous reports have demonstrated a late role for retinoids...

... Retinoids Retinoic acid Teratogenesis Spina bifida Caudal regression Cyp26a1 RARγ Wnt3a Brachyury Fgf8 Hnf3b Cdx4 Hoxd11 Tbx6 Raldh2 Retinoic acid (RA), a biologically active metabolite of vitamin A(retinol), is a signaling molecule required for normal embryogenesis...

... treatments at these stages. We demonstrated by in ovo electroporation of a dominant negative retinoid receptor construct( dnRAR ) that retinoid signaling is required to initiate expression. Elevating CDX activity by ectopic expression of an activated form of a Xenopus Cdx gene ( XcadVP16 ) in the hindbrain...

..., J. P., Goering, L., Thaller, C. and Eichele, G. ( 1997 ). Retinoid signaling is required for the establishment of a ZPA and for the expression of Hoxb-8, a mediator of ZPA formation. Development 124 , 1643 -1651. MacLean, G., Abu-Abed, S., Dollé, P., Tahayato, P., Chambon, P. and Petkovich...

... for normal neural tube and limb development. Dev. Biol . 185 , 42 -54. Eichele, G. and Thaller, C. ( 1987 ). Characterization of concentration gradients of a morphogenetically active retinoid in the chick limb bud. J. Cell Biol . 105 , 1917 -1923. Francis, P. H., Richardson, M. K...

...@utoronto.ca ) 15 01 2001 13 03 2001 © 2001 by Company of Biologists 2001 Cardiomyocyte differentiation Heart development Left-right patterning Mouse mutant Myocardium Raldh2 Retinaldehyde dehydrogenase Retinoids Tbx5 One of the primary patterning decisions required...

... mutant Myocardium Raldh2 Retinaldehyde dehydrogenase Retinoids Tbx5 Retinoic acid (RA), the active metabolite of vitamin A, is an important signaling molecule for the vertebrate embryo. Administration of excess RA has striking teratogenic effects on early heart development. According...

... (e-mail: dolle@igbmc.u-strasbg.fr ) 25 10 1999 08 12 1999 © 1999 by Company of Biologists 1999 Anteroposterior patterning Mouse Nervous system Neural crest Raldh2 Retinaldehyde dehydrogenase Retinoids Rhombomeres Regional diversity in the vertebrate hindbrain...

... course analysis indicates that only the newly formed mesoderm at the headfold-presomite stage is competent for these retinoid effects. We conclude that retinoic acid, the active derivative of vitamin A, is essential for heart situs determination and morphogenesis. * Author for correspondence (e...

... expression in the wild-type, heterozygous and RXRα mutant mice. This gene was also downregulated in a retinoid-deficient rat embryo model. ATP content and medium Acyl-CoA dehydrogenase mRNA were lower in RXRα mutant hearts compared to wild-type mice. Ultrastructural studies showed that the density...

...-mail: m.maden@kcl.ac.uk ) 12 05 1997 © 1997 by Company of Biologists 1997 apoptosis retinoic acid retinoids nervous system development hindbrain Msx-2 Bmp-4 quail Studies of apoptosis in vertebrates, both in the organism as a whole and in the developing nervous system...

...Valerie Dupé; Marc Davenne; Jacques Brocard; Pascal Dollé; Manuel Mark; Andrée Dierich; Pierre Chambon; Filippo M. Rijli ABSTRACT Retinoids are essential for normal development and both deficiency and excess of retinoic acid (RA) are teratogenic. Retinoic acid response elements (RAREs) have been...

... in the normal development of photoreceptor cells in vivo. 11 05 1994 © 1994 by Company of Biologists 1994 rod photoreceptors neural retina neurogenesis retinoids rat development During the development of the vertebrate central nervous system, the proliferating cells...