...Mingyao Yang; Wenzhi Ma; Jon Oatley; Wan-Sheng Liu ABSTRACT Spermatogenesis begins when cell fate-committed prospermatogonia migrate to the basement membrane and initiate spermatogenesis in response to retinoic acid (RA) in the neonatal testis. The underlying cellular and molecular mechanisms...

... are still poorly understood. We show that inactivating Twist1 in the primitive meninges causes cortical folding in mice. Cell proliferation in the meninges is reduced, causing loss of arachnoid fibroblasts that express Raldh2, an enzyme required for retinoic acid synthesis. Regionalized loss of Raldh2...

...Oleksandr Kirsanov; Taylor A. Johnson; Bryan A. Niedenberger; Taylor N. Malachowski; Benjamin J. Hale; Qing Chen; Brad Lackford; Jiajia Wang; Anukriti Singh; Karen Schindler; Brian P. Hermann; Guang Hu; Christopher B. Geyer ABSTRACT Retinoic acid (RA) is the proposed mammalian ‘meiosis inducing...

... candidate markers that define such differentiation processes and examine their expression dynamics using computational lineage trajectory methods. We further show that exposure to exogenous retinoic acid causes defects in ventricular chamber size, dysregulation in FGF signaling and a shunt...

..., we show that retinoic acid-mediated signaling is important for the differentiation of precursors towards the Cxcl13 pos follicular dendritic cell (FDC) lineage, and also blocks lymphotoxin-mediated Ccl19 pos fibroblastic reticular cell lineage differentiation. Accordingly, at the day of birth we...

...Chun-Wei Feng; Guillaume Burnet; Cassy M. Spiller; Fiona Ka Man Cheung; Kallayanee Chawengsaksophak; Peter Koopman; Josephine Bowles ABSTRACT In mice, the entry of germ cells into meiosis crucially depends on the expression of stimulated by retinoic acid gene 8 ( Stra8 ). Stra8 is expressed...

...Aditi Dubey; Jianshi Yu; Tian Liu; Maureen A. Kane; Jean-Pierre Saint-Jeannet ABSTRACT All paired sensory organs arise from a common precursor domain called the pre-placodal region (PPR). In Xenopus , Zic1 non-cell autonomously regulates PPR formation by activating retinoic acid (RA) production...

...Kazuya Ono; Lisa L. Sandell; Paul A. Trainor; Doris K. Wu ABSTRACT Retinoic acid (RA), a vitamin A (retinol) derivative, has pleiotropic functions during embryonic development. The synthesis of RA requires two enzymatic reactions: oxidation of retinol into retinaldehyde by alcohol dehydrogenases...

...-Linde et al., 2001 ). Our present findings support the importance of NT-somite interactions that are pivotal for the normal patterning of trunk components. For example, opposite gradients of retinoic acid and Fgf8 in mesoderm are required for NT development ( Diez del Corral et al., 2003...

...Edward Daniel; Haley R. Barlow; Gabrielle I. Sutton; Xiaowu Gu; Yadanar Htike; Mitzy A. Cowdin; Ondine Cleaver ABSTRACT Proper organ development depends on coordinated communication between multiple cell types. Retinoic acid (RA) is an autocrine and paracrine signaling molecule essential...

...Diego Crespo; Luiz H. C. Assis; Henk J. G. van de Kant; Sjors de Waard; Diego Safian; Moline S. Lemos; Jan Bogerd; Rüdiger W. Schulz ABSTRACT Retinoic acid (RA) is crucial for mammalian spermatogonia differentiation, and stimulates Stra8 expression, a gene required for meiosis. Certain fish species...

...Norbert B. Ghyselinck; Gregg Duester ABSTRACT Retinoic acid (RA), a metabolite of retinol (vitamin A), functions as a ligand for nuclear RA receptors (RARs) that regulate development of chordate animals. RA-RARs can activate or repress transcription of key developmental genes. Genetic studies...

... as stem cells (self-renewal) or proliferate and differentiate to enter meiosis in response to retinoic acid (RA). Here, we sought to uncover elusive mechanisms regulating a key switch fundamental to spermatogonial fate: the capacity of spermatogonia to respond to RA. Using the developing mouse testis...

... show that retinoic acid (RA) signaling activity at the site of gland initiation is colocalized with expression of retinol metabolic genes Rdh10 and Aldh1a2 in the underlying SMG mesenchyme. Utilizing a novel ex vivo assay for SMG initiation developed for this study, we show that RDH10 and RA...

...Estela J. Jauregui; Debra Mitchell; Traci Topping; Cathryn A. Hogarth; Michael D. Griswold ABSTRACT Spermatogenesis in mammals is a very complex, highly organized process, regulated in part by testosterone and retinoic acid (RA). Much is known about how RA and testosterone signaling pathways...

...Maja B. Gere-Becker; Claudia Pommerenke; Thomas Lingner; Tomas Pieler ABSTRACT Retinoic acid (RA) is required for pancreas specification in Xenopus and other vertebrates. However, the gene network that is directly induced by RA signalling in this context remains to be defined. By RNA sequencing...

...Hans-Martin Pogoda; Iris Riedl-Quinkertz; Heiko Löhr; Joshua S. Waxman; Rodney M. Dale; Jacek Topczewski; Stefan Schulte-Merker; Matthias Hammerschmidt ABSTRACT Zebrafish mutants with increased retinoic acid (RA) signaling due to the loss of the RA-inactivating enzyme Cyp26b1 develop a hyper...

... to their origin unless treated with retinoic acid (RA), which results in proximodistal (PD) limb duplications. Little is known about the transcriptional network that regulates PD duplication. In this study, we target specific retinoic acid receptors (RARs) to either PD duplicate (RA treatment or RARγ agonist...

...Yao Chen; Li Ma; Cathryn Hogarth; Gang Wei; Michael D. Griswold; Ming-Han Tong ABSTRACT Retinoic acid (RA) signaling is crucial for spermatogonial differentiation, which is a key step for spermatogenesis. We explored the mechanisms underlying spermatogonial differentiation by targeting expression...

... neurogenesis. These mutants carry lesions in gdf6a , a gene encoding a BMP family member previously implicated in dorsoventral patterning of the eye. We show that gdf6a mutant eyes exhibit expanded retinoic acid (RA) signalling and demonstrate that exogenous activation of this pathway in wild-type eyes...