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Keywords: Retinoic acid
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Journal Articles
Journal: Development
Development dev.200557.
Published: 10 June 2022
... markers that define such differentiation processes and examine their expression dynamics utilizing computational lineage trajectory methods. We further show that exposure to exogenous retinoic acid causes defects in ventricular chamber size, dysregulation in FGF signaling and a shunt in differentiation...
Journal Articles
Journal: Development
Development (2021) 148 (20): dev199713.
Published: 26 October 2021
..., we show that retinoic acid-mediated signaling is important for the differentiation of precursors towards the Cxcl13 pos follicular dendritic cell (FDC) lineage, and also blocks lymphotoxin-mediated Ccl19 pos fibroblastic reticular cell lineage differentiation. Accordingly, at the day of birth we...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (5): dev194977.
Published: 9 March 2021
...Chun-Wei Feng; Guillaume Burnet; Cassy M. Spiller; Fiona Ka Man Cheung; Kallayanee Chawengsaksophak; Peter Koopman; Josephine Bowles ABSTRACT In mice, the entry of germ cells into meiosis crucially depends on the expression of stimulated by retinoic acid gene 8 ( Stra8 ). Stra8 is expressed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (4): dev193227.
Published: 16 February 2021
...Aditi Dubey; Jianshi Yu; Tian Liu; Maureen A. Kane; Jean-Pierre Saint-Jeannet ABSTRACT All paired sensory organs arise from a common precursor domain called the pre-placodal region (PPR). In Xenopus , Zic1 non-cell autonomously regulates PPR formation by activating retinoic acid (RA) production...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (15): dev192070.
Published: 7 August 2020
...Kazuya Ono; Lisa L. Sandell; Paul A. Trainor; Doris K. Wu ABSTRACT Retinoic acid (RA), a vitamin A (retinol) derivative, has pleiotropic functions during embryonic development. The synthesis of RA requires two enzymatic reactions: oxidation of retinol into retinaldehyde by alcohol dehydrogenases...
Journal Articles
Journal: Development
Development (2020) 147 (10): dev183996.
Published: 26 May 2020
...-range activity of hedgehog signaling peptides . Dev. Biol.   236 , 364 - 386 . 10.1006/dbio.2001.0336 Gupta , S. and Sen , J. ( 2015 ). Retinoic acid signaling regulates development of the dorsal forebrain midline and the choroid plexus in the chick . Development   142 , 1293...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (4): dev181560.
Published: 20 February 2020
...Edward Daniel; Haley R. Barlow; Gabrielle I. Sutton; Xiaowu Gu; Yadanar Htike; Mitzy A. Cowdin; Ondine Cleaver ABSTRACT Proper organ development depends on coordinated communication between multiple cell types. Retinoic acid (RA) is an autocrine and paracrine signaling molecule essential...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2019) 146 (21): dev178665.
Published: 4 November 2019
...Diego Crespo; Luiz H. C. Assis; Henk J. G. van de Kant; Sjors de Waard; Diego Safian; Moline S. Lemos; Jan Bogerd; Rüdiger W. Schulz ABSTRACT Retinoic acid (RA) is crucial for mammalian spermatogonia differentiation, and stimulates Stra8 expression, a gene required for meiosis. Certain fish species...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev167502.
Published: 4 July 2019
...Norbert B. Ghyselinck; Gregg Duester ABSTRACT Retinoic acid (RA), a metabolite of retinol (vitamin A), functions as a ligand for nuclear RA receptors (RARs) that regulate development of chordate animals. RA-RARs can activate or repress transcription of key developmental genes. Genetic studies...
Journal Articles
Journal: Development
Development (2019) 146 (12): dev173088.
Published: 13 May 2019
... as stem cells (self-renewal) or proliferate and differentiate to enter meiosis in response to retinoic acid (RA). Here, we sought to uncover elusive mechanisms regulating a key switch fundamental to spermatogonial fate: the capacity of spermatogonia to respond to RA. Using the developing mouse testis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (15): dev164822.
Published: 2 August 2018
... show that retinoic acid (RA) signaling activity at the site of gland initiation is colocalized with expression of retinol metabolic genes Rdh10 and Aldh1a2 in the underlying SMG mesenchyme. Utilizing a novel ex vivo assay for SMG initiation developed for this study, we show that RDH10 and RA...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2018) 145 (13): dev160465.
Published: 9 July 2018
...Estela J. Jauregui; Debra Mitchell; Traci Topping; Cathryn A. Hogarth; Michael D. Griswold ABSTRACT Spermatogenesis in mammals is a very complex, highly organized process, regulated in part by testosterone and retinoic acid (RA). Much is known about how RA and testosterone signaling pathways...
Journal Articles
Journal: Development
Development (2018) 145 (12): dev161372.
Published: 8 June 2018
...Maja B. Gere-Becker; Claudia Pommerenke; Thomas Lingner; Tomas Pieler ABSTRACT Retinoic acid (RA) is required for pancreas specification in Xenopus and other vertebrates. However, the gene network that is directly induced by RA signalling in this context remains to be defined. By RNA sequencing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (9): dev159418.
Published: 8 May 2018
...Hans-Martin Pogoda; Iris Riedl-Quinkertz; Heiko Löhr; Joshua S. Waxman; Rodney M. Dale; Jacek Topczewski; Stefan Schulte-Merker; Matthias Hammerschmidt ABSTRACT Zebrafish mutants with increased retinoic acid (RA) signaling due to the loss of the RA-inactivating enzyme Cyp26b1 develop a hyper...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (4): 601–611.
Published: 15 February 2017
... to their origin unless treated with retinoic acid (RA), which results in proximodistal (PD) limb duplications. Little is known about the transcriptional network that regulates PD duplication. In this study, we target specific retinoic acid receptors (RARs) to either PD duplicate (RA treatment or RARγ agonist...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (9): 1502–1511.
Published: 1 May 2016
...Yao Chen; Li Ma; Cathryn Hogarth; Gang Wei; Michael D. Griswold; Ming-Han Tong ABSTRACT Retinoic acid (RA) signaling is crucial for spermatogonial differentiation, which is a key step for spermatogenesis. We explored the mechanisms underlying spermatogonial differentiation by targeting expression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (7): 1087–1098.
Published: 1 April 2016
... neurogenesis. These mutants carry lesions in gdf6a , a gene encoding a BMP family member previously implicated in dorsoventral patterning of the eye. We show that gdf6a mutant eyes exhibit expanded retinoic acid (RA) signalling and demonstrate that exogenous activation of this pathway in wild-type eyes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (7): 1205–1216.
Published: 1 April 2016
...Shirine Jeradi; Matthias Hammerschmidt We have previously shown that, in human and zebrafish, hypomorphic mutations of the gene encoding the retinoic acid (RA)-metabolizing enzyme Cyp26b1 result in coronal craniosynostosis, caused by an RA-induced premature transitioning of suture osteoblasts...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (7): 1293–1298.
Published: 1 April 2015
...Sandeep Gupta; Jonaki Sen The developing forebrain roof plate (RP) contains a transient signaling center, perturbations in which have been linked to holoprosencephaly (HPE). Here, we describe a novel domain of retinoic acid (RA) signaling that is specific to the chick RP and demonstrate that RA...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (22): 4375–4384.
Published: 15 November 2014
... or relative axial placement of territories can severely compromise their integration and function. Here, we show that coordination of neural and mesodermal tissue at the zebrafish head-trunk transition crucially depends on two novel activities of the signaling factor retinoic acid (RA): one specifying...
Includes: Supplementary data