...Michael L. Kaufman; Noah B. Goodson; Ko Uoon Park; Michael Schwanke; Emma Office; Sophia R. Schneider; Joy Abraham; Austin Hensley; Kenneth L. Jones; Joseph A. Brzezinski ABSTRACT During retinal development, a large subset of progenitors upregulates the transcription factor Otx2 , which is required...

.... Together, these data represent a valuable resource shedding light on transcription factor sequences and guidance cue dynamics during mouse retinal development. * Author for correspondence ( pierre.fabre@unige.ch ) Competing interests The authors declare no competing or financial interests...

... forward. Retinal development Stem cell Regenerative medicine Degenerative retinal diseases Macular degeneration Retina pigment epithelial cells The retina consists of the multi-layered neural retina (NR) and the monolayer of retinal pigment epithelium (RPE). As with other parts...

... and BMP signals play a role in setting up DV polarity in mouse ESC-derived optic cups. Morphogenesis Organoid culture Pattern formation Retinal development Vertebrate eye development is a complex event that requires rigorous polarity regulation with specific gene expression patterns...

... proteins. Fig. 6. Fat3 and Ena/VASP proteins are enriched in the IPL throughout retinal development. (A) Western blot analysis confirmed the presence of Mena, VASP and EVL in retinal lysates from E17.5 to P11, which spans amacrine cell development. Actin loading controls are shown underneath each...

...Andrea Barabino; Vicky Plamondon; Mohamed Abdouh; Wassim Chatoo; Anthony Flamier; Roy Hanna; Shufeng Zhou; Noboru Motoyama; Marc Hébert; Joëlle Lavoie; Gilbert Bernier ABSTRACT Retinal development occurs through the sequential but overlapping generation of six types of neuronal cells and one glial...

... development, a complete eye is formed but is subsequently lost. In Astyanax mexicanus , another blind cavefish, eye loss has been attributed to interference during eye field patterning. To address whether similar pathways have been targeted by evolution independently, we investigated the retinal development...

... by The Company of Biologists Ltd 2013 Cell fate Eye Gsk3β Mitf Optic vesicle patterning Optic cup Retinal development Smad Vsx2 During vertebrate eye development, the optic neuroepithelium is specified into three domains: retinal pigment epithelium (RPE), neural retina (NR...

... and neuronal morphogenesis during embryonic and retinal development. Here we show that Abl is required for photoreceptor cell fate maintenance, as Abl mutant photoreceptors lose neuronal markers during late pupal stages but do not re-enter a proliferative state or undergo apoptosis. Failure to maintain...

... autonomous modes of organogenesis and homeostasis. We also attempt to interpret the results of previous in vivo studies of retinal development in light of the self-organising nature of the retina. * Author for correspondence ( yoshikisasai@cdb.riken.jp ) Competing interests statement The authors...

... interests. 4 5 2010 © 2010. 2010 Neurogenesis Retinal development Transcription regulation Medaka The vertebrate retina is a layered structure composed of six neuronal and one glial cell type, which are organised in three cellular layers: the ganglion cell layer, comprising...

... POU domain MATH5 ATOH7 POU4F2 RGC Retinal development Transcription factor Owing to its easy accessibility and well-organized laminar structure, the retina has long served as an ideal experimental model for studying the central nervous system (CNS). Retinogenesis in vertebrates...

..., Metabolism and Endocrinology, Juntendo University,2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan 30 8 2006 © 2006. 2006 Retinal development Basic helix-loop-helix Amacrine cell Horizontal cell Ganglion cell Lineage tracing Ptf1a Foxn4 Progenitor Cell specification...

...@uni-duesseldorf.de ) 21 2 2005 ©2005. 2005 Zonula adherens crumbs Notch RhoA (Rho1) Retinal development Morphogenesis during animal development involves not only the specification of particular cell fates and differentiation of specific cell types...

... continues to develop as neural retina, indicating that sustained FGF9 stimulation is not necessary for retinal development. Further evidence that a transient signal is sufficient to switch the RPE differentiation pathway comes from the transgenic mice that express FGF9 or activated Ras under the control...

... for correspondence (e-mail: ucbtcne@ucl.ac.uk ) 11 04 1997 © 1997 by Company of Biologists 1997 mouse retina rod photoreceptors retinal development LIF Müller cells The major classes of cells in the vertebrate neural retina, including photoreceptors, neurons and Müller glial cells...

... in a single row. This reorganisation is a prerequisite for the identification of death candidates. Irregular chiasmC-roughest function in retinal development demonstrates the importance of specific cell contacts for assignment of the apoptotic fate. * Author for correspondence 27 03 1996 ©...

... 1995 by Company of Biologists 1995 integrin α 2 β 1 retinal development collagen receptor chick eye extracellular matrix The development of the central nervous system involves both extrinsic and intrinsic signals which influence neuronal differentiation. The retina is an example...

... strongly suggests that the adult mosaic is cryptically present at a time when the photoreceptors are morphologically indistinguishable from one another. © 1990 by Company of Biologists 1990 retinal development double cones cone mosaic photoreceptors cell patterning In the retinas...