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Keywords: Ret
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Journal Articles
In collection:
Neural development
Journal: Development
Development (2021) 148 (16): dev197020.
Published: 12 August 2021
... that Lrig1 acts through this mechanism to inhibit Ret activity. However, it is unclear whether other Lrig family members play similar roles. Here, we show that Lrig1 and Lrig3 are co-expressed in Ret-positive mouse dorsal root ganglion (DRG) neurons. Lrig3, like Lrig1, interacts with Ret and inhibits GDNF...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2017) 144 (12): 2282–2293.
Published: 15 June 2017
... of the prostatic epithelium. However, the nature of the AR-regulated morphogenetic genes and the mechanisms whereby AR controls prostate development are not understood. Glial cell line-derived neurotrophic factor (GDNF) binds GDNF family receptor α1 (GFRα1) and signals through activation of RET tyrosine kinase...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (15): 2696–2703.
Published: 1 August 2015
... indicates that both genes play partially redundant roles in ureterovesical junction formation. Aspects of the Yap −/− phenotype resemble hypersensitivity to RET signaling, including excess budding of the ND, increased phospho-ERK and increased expression of Crlf1 , Sprouty1 , Etv4 and Etv5 . Importantly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (13): 2405–2415.
Published: 1 July 2012
...Masato Hoshi; Ekatherina Batourina; Cathy Mendelsohn; Sanjay Jain Mutations in the receptor tyrosine kinase RET are associated with congenital anomalies of kidneys or urinary tract (CAKUT). RET tyrosine Y1015 is the docking site for PLCγ, a major regulator of RET signaling. Abrogating signaling via...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (18): 3007–3011.
Published: 15 September 2008
... and colonises the entire gastrointestinal tract to form the enteric nervous system(ENS). The colonisation of embryonic gut by NCCs has been studied extensively in chick embryos, and genetic studies in mice have identified genes crucial for ENS development, including Ret . Here, we have combined mouse embryo...
Journal Articles
Journal: Development
Development (2004) 131 (21): 5503–5513.
Published: 1 November 2004
...Sanjay Jain; Cathy K. Naughton; Mao Yang; Amy Strickland; Kiran Vij; Mario Encinas; Judy Golden; Akshay Gupta; Robert Heuckeroth; Eugene M. Johnson, Jr; Jeffrey Milbrandt The Ret receptor tyrosine kinase mediates physiological signals of glial cell line-derived neurotrophic factor (GDNF) family...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (14): 3345–3356.
Published: 15 July 2004
... the Ret receptor and another gene Wnt11 in the ureteric bud (B,C). At the same developmental stage, Gdnf (A′) and Wnt11 (C′) expression is reduced in response to human SPRY2 expression, while Ret remains unchanged(B′). Note that there are less ureteric tips in the kidneys expressing human SPRY2...
Journal Articles
Journal: Development
Development (2004) 131 (1): 241–249.
Published: 1 January 2004
... along its length. Both gfra1a and gfra1b as well as ret are expressed at this time, while gfra2 expression, the receptor component that binds the GDNF-related ligand neurturin, is not detected until the precursors have migrated along the gut. Gfra genes are also expressed in regions of the zebrafish...
Journal Articles
Journal: Development
Development (2003) 130 (14): 3175–3185.
Published: 15 July 2003
... branching morphogenesis defects and consequent kidney hypoplasia in newborn mice. Wnt11 functions, in part, by maintaining normal expression levels of the gene encoding glial cell-derived neurotrophic factor (Gdnf). Gdnf encodes a mesenchymally produced ligand for the Ret tyrosine kinase receptor...
Journal Articles
Journal: Development
Development (2003) 130 (10): 2187–2198.
Published: 15 May 2003
...Scott Gianino; John R. Grider; Jennifer Cresswell; Hideki Enomoto; Robert O. Heuckeroth To clarify the role of Ret signaling components in enteric nervous system(ENS) development, we evaluated ENS anatomy and intestinal contractility in mice heterozygous for Ret, GFRα1 and Ret ligands...
Journal Articles
Journal: Development
Development (2002) 129 (22): 5151–5160.
Published: 15 November 2002
... in a rostrocaudal direction, colonise in an orderly fashion the rest of the foregut, the midgut and the hindgut. We provide evidence that activation of the receptor tyrosine kinase RET by glial cell line-derived neurotrophic factor (GDNF) is required for the directional migration of ENS progenitors towards...
Journal Articles
Journal: Development
Development (2001) 128 (20): 3963–3974.
Published: 15 October 2001
... occurs following the primary sympathetic chain formation, where precursors of sympathetic neurons migrate and project axons along or toward blood vessels. We demonstrate that, in Ret -deficient mice, neuronal precursors throughout the entire sympathetic nervous system fail to migrate and project axons...
Journal Articles
Journal: Development
Development (2001) 128 (19): 3773–3782.
Published: 1 October 2001
... at early embryonic ages almost entirely suppresses ciliary axon outgrowth. These results demonstrate that target-derived GDNF is necessary for ciliary ganglion neurons to innervate ciliary muscle in the eye. Since the down-regulation of GDNF in the eye is accompanied by down-regulation of GFRα1 and Ret...