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Keywords: Repression
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Journal Articles
Journal: Development
Development (2019) 146 (10): dev172486.
Published: 15 May 2019
...Megan E. Dowdle; Sookhee Park; Susanne Blaser Imboden; Catherine A. Fox; Douglas W. Houston; Michael D. Sheets ABSTRACT Bicaudal-C (Bicc1) is a conserved RNA-binding protein that represses the translation of selected mRNAs to control development. In Xenopus embryos, Bicc1 binds and represses...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (20): 4256–4265.
Published: 15 October 2013
... more than one, with Drosophila Brinker (Brk) recruiting the co-repressors CtBP and Groucho (Gro), in addition to possessing a third repression domain, 3R. Previous studies indicated that Gro is sufficient for Brk to repress targets in the wing, questioning why it should need to recruit CtBP, a short...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (9): 1892–1902.
Published: 1 May 2013
...Qi Dai; Celia Andreu-Agullo; Ryan Insolera; Li Chin Wong; Song-Hai Shi; Eric C. Lai The activity of the Notch pathway revolves around a CSL-class transcription factor, which recruits distinct complexes that activate or repress target gene expression. The co-activator complex is deeply conserved...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (9): 1547–1556.
Published: 1 May 2012
...Yun Li; Jean Z. Maines; Ömür Y. Tastan; Dennis M. McKearin; Michael Buszczak In the Drosophila ovary, bone morphogenetic protein (BMP) ligands maintain germline stem cells (GSCs) in an undifferentiated state. The activation of the BMP pathway within GSCs results in the transcriptional repression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (19): 4291–4299.
Published: 1 October 2011
... scintillation cocktail (MPI 882470) were added and the vial was loaded into a liquid scintillation counter (Beckman LS6000 LL). The probe was diluted to 20,000 cpm/μl using 10 mM Tris (pH 8.0). Combinatorial control Embryogenesis Repression Transcription Drosophila Establishing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (18): 4075–4084.
Published: 15 September 2011
... declare no competing financial interests. 15 7 2011 © 2011. Cis-regulatory modules Gene expression Drosophila melanogaster snail Developmental patterning Repression Huckebein Our data show that expression of the Drosophila snail gene in embryos...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (5): 829–837.
Published: 1 March 2008
... induces expression of tll and hkb by locally inhibiting repression exerted by Gro and Cic ( Jiménez et al., 2000 ; Paroush et al.,1997 ). Phosphorylation of Cic by MAPK is one molecular mechanism employed by the Torso pathway to relieve repression in terminal regions( Astigarraga et al., 2007 );once...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (20): 3585–3592.
Published: 15 October 2007
... these interactions might affect target gene activation or repression. We find that two Smad proteins, effectors of the Drosophila Dpp/TGF-β pathway, that are genetically required for the activation of the spalt ( sal ) gene in the wing,collaborate with the Hox protein Ultrabithorax (Ubx) to directly repress sal...
Journal Articles
Journal: Development
Development (2005) 132 (17): 3963–3976.
Published: 1 September 2005
...). PcG genes are essential genes in higher eukaryotes responsible for the maintenance of the spatially distinct repression of developmentally important regulators such as the homeotic genes. Their absence, as well as overexpression, causes transformations in the axial organization of the body. Although...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (24): 6071–6081.
Published: 15 December 2004
...Stephanie E. Winter; Gerard Campbell Patterning along developing body axes is regulated by gradients of transcription factors, which activate or repress different genes above distinct thresholds. Understanding differential threshold responses requires knowledge of how these factors regulate...
Journal Articles
Journal: Development
Development (2004) 131 (17): 4189–4200.
Published: 1 September 2004
.... * Author for correspondence (e-mail: thompsonc@kennedykrieger.org ) 9 6 2004 © 2004. 2004 Hair follicle Alopecia Nuclear receptor Repression Epidermis hr The skin is a dynamic and complex organ. To serve its function as a barrier to the environment, the skin must maintain...
Journal Articles
Journal: Development
Development (2004) 131 (10): 2419–2429.
Published: 15 May 2004
...Paolo Struffi; Maria Corado; Meghana Kulkarni; David N. Arnosti The Drosophila Knirps protein is a short-range transcriptional repressor that locally inhibits activators by recruiting the CtBP co-repressor. Knirps also possesses CtBP-independent repression activity. The functional importance...
Journal Articles
Journal: Development
Development (2002) 129 (21): 4931–4940.
Published: 1 November 2002
... in all nuclei anterior to the stripe 2 position. The gap gene giant ( gt ) is involved in a repression mechanism that sets the anterior stripe border, but genetic removal of gt (or deletion of Gt-binding sites) causes stripe expansion only in the anterior subregion that lies adjacent to the stripe border...
Journal Articles
Journal: Development
Development (2002) 129 (12): 2917–2927.
Published: 15 June 2002
... Xmyf-5 ( Xtmyf-5 ) genomic DNA fragment that accurately recapitulates the expression of the endogenous gene. Deletion and mutational analysis has identified HBX2, an essential element, approximately 1.2 kb upstream from the start of transcription, which is necessary for both activation and repression...
Journal Articles
Journal: Development
Development (2001) 128 (24): 5189–5199.
Published: 15 December 2001
... transcriptional repressor with a minimal 36 amino acid repression domain which can mediate promoter-specific repression by suppressing the activity of homeodomain-containing activator proteins. Mutations in HESX1 associated with pituitary disease appear to modulate the DNA-binding affinity of HESX1 rather than...
Journal Articles
Journal: Development
Development (2001) 128 (21): 4361–4370.
Published: 1 November 2001
... ranging from sex determination to embryonic patterning and neuroblast specification. We have characterized a function of Gro in imaginal development, namely the repression of hedgehog ( hh ) in anterior wing pouch cells. hh encodes a secreted morphogen with potent patterning activities. In Drosophila...
Journal Articles
Journal: Development
Development (2001) 128 (15): 2975–2987.
Published: 1 August 2001
... by VP16-Gsc was fully rescued by Frzb, a secreted Wnt inhibitor, indicating that activation of ectopic Wnt signaling was responsible, at least in part, for the anterior defects. Supporting this idea, Xwnt8 expression was activated by VP16-Gsc in animal explants and the dorsal marginal zone, and repressed...