...Tyler A. Square; Emma J. Mackey; Shivani Sundaram; Naama C. Weksler; Zoe Z. Chen; Sujanya N. Narayanan; Craig T. Miller ABSTRACT Most vertebrate species undergo tooth replacement throughout adult life. This process is marked by the shedding of existing teeth and the regeneration of tooth organs...

...Clayton J. Becker; Valentina Cigliola; Pierre Gillotay; Ashley Rich; Alessandro De Simone; Yanchao Han; Stefano Di Talia; Kenneth D. Poss Identification of signaling events that contribute to innate spinal cord regeneration in zebrafish can inform new targets for modulating injury responses...

...Yu-Lieh Lin; Ling Yu; Mingquan Yan; Katherine Zimmel; Osama Qureshi; Felisha Imholt; Tao Li; Ivan Ivanov; Regina Brunauer; Lindsay Dawson; Ken Muneoka ABSTRACT A mouse organoid culture model was developed to regenerate articular cartilage by sequential treatment with BMP2 and BMP9 (or GDF2...

...Ahmed I. Mahmoud ABSTRACT Metabolic switches are a crucial hallmark of cellular development and regeneration. In response to changes in their environment or physiological state, cells undergo coordinated metabolic switching that is necessary to execute biosynthetic demands of growth and repair...

...Bidushi Chandra; Matthew G. Voas; Erin L. Davies; Rachel H. Roberts-Galbraith ABSTRACT Glia play multifaceted roles in nervous systems in response to injury. Depending on the species, extent of injury and glial cell type in question, glia can help or hinder the regeneration of neurons. Studying...

...Jonathan D. Louie; Benjamin H. Bromberg; Matthew J. Zunitch; James E. Schwob ABSTRACT Horizontal basal cells (HBCs) residing within severely damaged olfactory epithelium (OE) mediate OE regeneration by differentiating into odorant-detecting olfactory sensory neurons (OSNs) and other tissue...

... was suppressed by rapamycin-mediated inhibition of TOR signaling. As TOR signaling is also required for heart restoration after cryoinjury, we compared transcriptomes of hyperplastic and regenerating ventricles. Both conditions were associated with upregulation of cardiomyocyte dedifferentiation...

... in adult zebrafish. Using a newly generated CreER T2 transgenic line, we show that the cells directing expression of the bridging glial marker ctgfa give rise to regenerating glia after injury, with negligible contribution to either neuronal or oligodendrocyte lineages. A 1 kb sequence upstream...

... expression during zebrafish sensory hair cell regeneration . Dev. Cell 57 , 799 - 819.e6 . 10.1016/j.devcel.2022.03.001 Bodor , D. L. , Pönisch , W. , Endres , R. G. and Paluch , E. K. ( 2020 ). Of cell shapes and motion: the physical basis of animal cell migration . Dev...

...Sorrel Tran; Yun-Fan Stephanie Chen; Dawei Xu; Madalene Ison; Li Yang ABSTRACT De novo root regeneration (DNRR) is a developmental process that regenerates adventitious roots from wounded tissues. Phytohormone signaling pathways involved in microbial resistance are mobilized after cutting...

... on cardiomyocyte proliferation during postnatal development, we sought to evaluate whether Runx1 can similarly induce cardiomyocyte proliferation and myocardial regeneration in an injury context. Here, we simulated myocardial infarction (MI) by permanent ligation of the left anterior descending (LAD) artery...

... , T. , Murawala , P. , Knapp , D. , Masselink , W. , Schuez , M. , Hermann , S. , Gac-Santel , M. , Nowoshilow , S. , Kageyama , J. , Khattak , S. et al. ( 2018 ). Single-cell analysis uncovers convergence of cell identities during axolotl limb regeneration...

...Aldine R. Amiel; Stephanie L. Tsai; Daniel Wehner ABSTRACT The eighth EMBO conference in the series ‘The Molecular and Cellular Basis of Regeneration and Tissue Repair’ took place in Barcelona (Spain) in September 2022. A total of 173 researchers from across the globe shared their latest advances...

... and increased cell death leading to IVD degeneration. Moreover, Ccn2a overexpression promotes regeneration through accelerating cell proliferation and suppressing cell death in wild-type aged IVDs. Mechanistically, Ccn2a maintains IVD homeostasis and promotes IVD regeneration by enhancing outer annulus fibrosus...

... organoids in vitro from embryonic, fetal and adult cells, as well as pluripotent stem cells. We discuss how these systems have been used to learn new aspects of pancreas development, regeneration and disease, as well as their limitations and potential for future discoveries. * Author for correspondence...

... , A. ( 2008 ). Comparative aspects of animal regeneration . Annu. Rev. Cell Dev. Biol. 24 , 525 - 549 . 10.1146/annurev.cellbio.24.110707.175336 Brooks , A. , Kohl , K. , Brucker , R. , van Opstal , E. and Bordenstein , S. ( 2016 ). Phylosymbiosis: relationships...

... regenerate. In contrast, a graft of area opaca (without the posterior region) induced a thin ring of ASTL expression in the adjacent area pellucida in some embryos (5/13 with expression) ( P =0.0954, Boschloo's test) ( Fig. 1 F). Likewise, the isolated area opaca did not express ASTL (0/13; Fig. S1C...

...Hannah Brunsdon; Alessandro Brombin; Samuel Peterson; John H. Postlethwait; E. Elizabeth Patton ABSTRACT Melanocyte stem cells (McSCs) in zebrafish serve as an on-demand source of melanocytes during growth and regeneration, but metabolic programs associated with their activation and regenerative...

... repair and regeneration. We conclude by suggesting that comprehensive analyses of the immune system may enable biomedical applications in stem cell biology and regenerative medicine. National Institute of General Medical Sciences http://dx.doi.org/10.13039/100000057 R01GM132753...

... repair by scar formation and the initiation of tissue regeneration. They initially assume inflammatory phenotypes, releasing pro-inflammatory cytokines and removing dead and dying tissue, before entering a reparative stage, replacing dead muscle tissue with a non-contractile scar. In this Review, we...