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Keywords: Rbpj
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Journal Articles
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Reproductive biology
Journal: Development
Development (2022) 149 (11): dev200300.
Published: 13 June 2022
... data also suggest that the implantation chamber facilitates embryo rotation and its alignment along the uterine mesometrial-antimesometrial axis. Using WNT5A- and RBPJ-deficient mice that display aberrant folds, we show that embryos trapped in longitudinal folds display misalignment of the embryo...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (4): dev199735.
Published: 17 February 2022
... whether Notch signaling, a pathway previously implicated in vascular SMC development, also affects visceral SMC differentiation. We show that mice with a conditional deletion of the unique Notch mediator RBPJ in the undifferentiated ureteric mesenchyme exhibit altered ureter peristalsis with a delayed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (4): dev183665.
Published: 17 February 2020
... the differentiation of Pax2 + precursors into Sox2 + /Fgf3 + /Etv5 + caudal cells, at the expense of Vgll2 + /Irx5 + rostral cells and Neurog2 + dorsal-caudal pre-neural cells. Conversely, inhibition of canonical Notch signalling by deletion of Rbpj led to differentiation of Pax2 + precursors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (23): 4468–4478.
Published: 1 December 2014
... signaling in Sertoli cells has not been demonstrated. To this end, we conditionally ablated recombination signal binding protein for immunoglobulin kappa J region ( Rbpj ), a crucial mediator of NOTCH signaling, in Sertoli cells using Amh-cre . Rbpj knockout mice had: significantly increased testis sizes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (19): 3782–3792.
Published: 1 October 2014
... embryonic AV specification by promoting arterial, as opposed to venous, endothelial cell (EC) fate. To understand the essential role of endothelial Notch signaling in postnatal AV organization, we used inducible Cre-lox P recombination to delete Rbpj , a mediator of canonical Notch signaling, from postnatal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (24): 4536–4548.
Published: 15 December 2012
... cells with high Pax7 expression. By genetically modulating Notch activity, we demonstrate that activated Notch (NICD) blocks terminal differentiation in an Rbpj-dependent manner that is sufficient to sustain stem/progenitor cells throughout embryogenesis, despite the absence of committed progeny...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (16): 2757–2765.
Published: 15 August 2008
...Hassan Nakhai; Jens T. Siveke; Bettina Klein; Lidia Mendoza-Torres; Pawel K. Mazur; Hana Algül; Freddy Radtke; Lothar Strobl; Ursula Zimber-Strobl; Roland M. Schmid The role of the Notch signaling members Notch1, Notch2 and Rbpj in exocrine pancreatic development is not well defined. We therefore...