... is impaired in mice that lack osteoclasts. Last, we show that rapamycin can suppress the growth of bone lymphatics in our models of GLA and GSD. In summary, we show that bLECs can arise from pre-existing LECs and that rapamycin can prevent the growth of bone lymphatics. References Adams , J. R...

... , whereas lowering autophagy efficiency in the non-aging Hydra vulgaris induces an aging phenotype. Aging model system Autophagy sensor Epithelial stem cells Hydra regeneration Evolution of aging p62/SQSTM1 WIPI2 Rapamycin Studies using short-lived invertebrate organisms...

... not abolish, embryonic and adult myogenesis. Raptor Rictor Protein synthesis Satellite cells Muscle regeneration Rapamycin Myogenesis is a tightly controlled process that results in the formation of skeletal muscle in several distinct myogenic waves. During development, mesodermal...

...Ryan C. Russell; Chong Fang; Kun-Liang Guan The mammalian target of rapamycin (mTOR) is a kinase that responds to a myriad of signals, ranging from nutrient availability and energy status, to cellular stressors, oxygen sensors and growth factors. The finely tuned response of mTOR to these stimuli...