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Keywords: Raldh2
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Journal Articles
Journal: Development
Development (2014) 141 (15): 2972–2977.
Published: 1 August 2014
... trunk expression extending into somites and neuroectoderm. Epigenetic analysis using chromatin immunoprecipitation of trunk tissues from E8.25 wild-type and Raldh2 −/− embryos lacking RA synthesis revealed RA-dependent recruitment of the repressive histone marker H3K27me3 and polycomb repressive complex...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2011) 138 (1): 139–148.
Published: 1 January 2011
...Thomas Brade; Sandeep Kumar; Thomas J. Cunningham; Christina Chatzi; Xianling Zhao; Susana Cavallero; Peng Li; Henry M. Sucov; Pilar Ruiz-Lozano; Gregg Duester Epicardial signaling and Rxra are required for expansion of the ventricular myocardial compact zone. Here, we examine Raldh2 –/– and Rxra...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (14): 2649–2659.
Published: 15 July 2006
...Yann Gibert; Alexandra Gajewski; Axel Meyer; Gerrit Begemann Vertebrate forelimbs arise as bilateral appendages from the lateral plate mesoderm (LPM). Mutants in aldh1a2 ( raldh2 ), an embryonically expressed gene encoding a retinoic acid (RA)-synthesizing enzyme, have been used to show that limb...
Journal Articles
Journal: Development
Development (2006) 133 (10): 1901–1910.
Published: 15 May 2006
... expression patterns. Overlapping functions of these enzymes have hampered genetic efforts to elucidate RA function in the eye. Here, we report Raldh1, Raldh2 and Raldh3 single,double and triple null mice exhibiting progressively less or no RA synthesis in the eye. Our genetic studies indicate that RA...
Journal Articles
Journal Articles
Journal: Development
Development (2003) 130 (22): 5363–5374.
Published: 15 November 2003
... and RA signalling. We describe two phases of AP signalling by RA,reflected in RALDH2 expression. The first phase (HH4-7) is characterized by increasing proximity between sino-atrial precursors and the lateral mesoderm expressing RALDH2. In this phase, RA signalling is consistent with diffusion...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (7): 1449–1459.
Published: 1 April 2003
... in the adjacent trunk tissues by RALDH2, and that Cyp26a1 -null animals exhibit spina bifida and caudal agenesis. We now show that, in the absence of Cyp26a1 , retinoic acid receptor gamma (RARγ) mediates ectopic RA-signaling in the tail bud. We also show that activated RARγ results in downregulation of Wnt3a...
Journal Articles
Journal: Development
Development (2002) 129 (18): 4335–4346.
Published: 15 September 2002
... Cyp26 Raldh2 Zebrafish Studies of axis formation in Xenopus laevis have led to models in which two signaling events that are initiated by localized maternal determinants cause mesendoderm induction in the marginal zone, and organizer formation on its dorsal side at blastula-to-gastrula...
Journal Articles
Journal: Development
Development (2002) 129 (15): 3563–3574.
Published: 1 August 2002
... affects limb morphogenesis in mutant mouse embryos deficient for the retinaldehyde dehydrogenase 2 (Raldh2/Aldh1a2). These mutants, which have no detectable embryonic RA except in the developing retina, die at E9.5-E10 without any evidence of limb bud formation, but maternal RA supplementation through...
Journal Articles
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2001) 128 (7): 1109–1118.
Published: 1 April 2001
...@utoronto.ca ) 15 01 2001 13 03 2001 © 2001 by Company of Biologists 2001 Cardiomyocyte differentiation Heart development Left-right patterning Mouse mutant Myocardium Raldh2 Retinaldehyde dehydrogenase Retinoids Tbx5 One of the primary patterning decisions required...
Journal Articles
Journal: Development
Development (2001) 128 (7): 1019–1031.
Published: 1 April 2001
... established in a mammalian system. To block endogenous RA synthesis, we have disrupted the gene encoding RALDH2, the first retinaldehyde dehydrogenase whose expression has been detected during early mouse post-implantation development. We describe here the heart abnormalities of the RA-deficient Raldh2...
Journal Articles
Journal: Development
Development (2000) 127 (18): 3961–3970.
Published: 15 September 2000
... that endogenous Meis expression is maintained by RA signaling, and that stronger RA signaling in proximal versus distal limb regions may determine the proximal restriction of Meis expression. In agreement with this view, the expression of retinaldehyde dehydrogenase 2 ( Raldh2 ), encoding the main RA...
Journal Articles
Journal: Development
Development (2000) 127 (1): 75–85.
Published: 1 January 2000
...Karen Niederreither; Julien Vermot; Brigitte Schuhbaur; Pierre Chambon; Pascal Dollé ABSTRACT Targeted disruption of the murine retinaldehyde dehydrogenase 2 ( Raldh2 ) gene precludes embryonic retinoic acid (RA) synthesis, leading to midgestational lethality (Niederreither, K., Subbarayan, V...