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Keywords: Raldh2
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Journal Articles
Journal: Development
Development (2014) 141 (15): 2972–2977.
Published: 1 August 2014
... trunk expression extending into somites and neuroectoderm. Epigenetic analysis using chromatin immunoprecipitation of trunk tissues from E8.25 wild-type and Raldh2 −/− embryos lacking RA synthesis revealed RA-dependent recruitment of the repressive histone marker H3K27me3 and polycomb repressive complex...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (6): 1093–1097.
Published: 15 March 2011
... to relate to a retinoic acid (RA) receptor-dependent mechanism. RA is a potent morphogen synthesised by Raldh enzymes, Raldh2 being the predominant one in mesodermal tissues. Despite the importance of epicardial retinoid signalling in the heart, the molecular mechanisms controlling cardiac Raldh2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (1): 139–148.
Published: 1 January 2011
...Thomas Brade; Sandeep Kumar; Thomas J. Cunningham; Christina Chatzi; Xianling Zhao; Susana Cavallero; Peng Li; Henry M. Sucov; Pilar Ruiz-Lozano; Gregg Duester Epicardial signaling and Rxra are required for expansion of the ventricular myocardial compact zone. Here, we examine Raldh2 –/– and Rxra...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (14): 2649–2659.
Published: 15 July 2006
...Yann Gibert; Alexandra Gajewski; Axel Meyer; Gerrit Begemann Vertebrate forelimbs arise as bilateral appendages from the lateral plate mesoderm (LPM). Mutants in aldh1a2 ( raldh2 ), an embryonically expressed gene encoding a retinoic acid (RA)-synthesizing enzyme, have been used to show that limb...
Journal Articles
Journal: Development
Development (2006) 133 (10): 1901–1910.
Published: 15 May 2006
... expression patterns. Overlapping functions of these enzymes have hampered genetic efforts to elucidate RA function in the eye. Here, we report Raldh1, Raldh2 and Raldh3 single,double and triple null mice exhibiting progressively less or no RA synthesis in the eye. Our genetic studies indicate that RA...
Journal Articles
Journal: Development
Development (2005) 132 (7): 1611–1621.
Published: 1 April 2005
.... Here, we have investigated the functions of local RA synthesis in the process of motoneuron specification and early differentiation using a conditional knockout strategy that ablates the function of the retinaldehyde dehydrogenase 2 (Raldh2) synthesizing enzyme essentially in brachial motoneurons...
Journal Articles
Journal: Development
Development (2003) 130 (22): 5363–5374.
Published: 15 November 2003
... and RA signalling. We describe two phases of AP signalling by RA,reflected in RALDH2 expression. The first phase (HH4-7) is characterized by increasing proximity between sino-atrial precursors and the lateral mesoderm expressing RALDH2. In this phase, RA signalling is consistent with diffusion...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (7): 1449–1459.
Published: 1 April 2003
... in the adjacent trunk tissues by RALDH2, and that Cyp26a1 -null animals exhibit spina bifida and caudal agenesis. We now show that, in the absence of Cyp26a1 , retinoic acid receptor gamma (RARγ) mediates ectopic RA-signaling in the tail bud. We also show that activated RARγ results in downregulation of Wnt3a...
Journal Articles
Journal: Development
Development (2002) 129 (18): 4335–4346.
Published: 15 September 2002
... and Wnts to promote expression of these posterior genes depends upon RA. In part, this is likely to be due to the ability of Fgfs and Wnts to promote RA activity through suppression of cyp26 expression, but is also likely to be due to additional regulatory events, such as promotion of raldh2 expression...
Journal Articles
Journal: Development
Development (2002) 129 (15): 3563–3574.
Published: 1 August 2002
... affects limb morphogenesis in mutant mouse embryos deficient for the retinaldehyde dehydrogenase 2 (Raldh2/Aldh1a2). These mutants, which have no detectable embryonic RA except in the developing retina, die at E9.5-E10 without any evidence of limb bud formation, but maternal RA supplementation through...
Journal Articles
Journal: Development
Development (2002) 129 (12): 2851–2865.
Published: 15 June 2002
... the identification and expression pattern of the zebrafish retinaldehyde dehydrogenase2 ( raldh2/aldh1a2 ) gene. Raldh2 synthesises retinoic acid (RA) from its immediate precursor retinal. It is expressed in a highly ordered spatial and temporal fashion during gastrulation in the involuting mesoderm and during later...
Journal Articles
Journal: Development
Development (2002) 129 (9): 2271–2282.
Published: 1 May 2002
...Felix A. Mic; Robert J. Haselbeck; Arnold E. Cuenca; Gregg Duester Retinoid control of vertebrate development depends upon tissue-specific metabolism of retinol to retinoic acid (RA). The RA biosynthetic enzyme RALDH2 catalyzes much, but not all, RA production in mouse embryos, as revealed here...
Journal Articles
Journal: Development
Development (2001) 128 (16): 3081–3094.
Published: 15 August 2001
... acid in signalling between the paraxial mesoderm and neural tube. To investigate whether loss of RALDH2 activity could account for the nls phenotype, we injected raldh2 -specific morpholino antisense oligonucleotides into wild-type embryos and assayed the ensuing effects by in situ hybridisation...