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Keywords: Rac1
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Journal Articles
Journal: Development
Development (2021) 148 (23): dev200001.
Published: 2 December 2021
... ion channel Piezo1 on the migration of the neural crest, a multipotent embryonic cell population. We identify that Piezo1 is required for the migration of Xenopus cephalic neural crest. We show that loss of Piezo1 promotes focal adhesion turnover and cytoskeletal dynamics by controlling Rac1 activity...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (1): 174–184.
Published: 1 January 2015
..., followed by their correct spacing and planar orientation. Here, we report a novel role for ELMO-DOCK1, which is a bipartite guanine nucleotide exchange factor complex for the small GTPase Rac1, and for the membrane-cytoskeletal linker Ezrin, in regulating centriole/basal body migration, docking and spacing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (8): 1551–1562.
Published: 15 April 2011
... guanine nucleotide exchange factor (GEF) Mbc plays a fundamental role in the FCMs, where it functions to activate Rac1, but is not required in the founder cells for fusion. Mbc, active Rac1 and F-actin foci are highly enriched in the FCMs, where they localize to the Sns:Kirre junction. Furthermore, Mbc...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (10): 1771–1780.
Published: 15 May 2008
... Wnt signaling PCP RhoA Rac1 © 2008. 2008 19 3 2008 * Author for correspondence (e-mail: r.mayor@ucl.ac.uk ) This highly localized expression of syn4 prompted us to analyze its function in NC development. Two morpholino antisense oligonucleotides(MO1, MO2) were developed...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (19): 4309–4316.
Published: 1 October 2005
...-specific kinase, a component of the agrin receptor complex, abolished these effects of agrin. Agrin-induced repulsive growth-cone turning requires the activity of PI3-kinase and Ca 2+ signaling. In addition, the expression of dominant-negative Rac1 inhibited neurite extension and blocked agrin-mediated...
Journal Articles
Journal: Development
Development (2004) 131 (3): 525–537.
Published: 1 February 2004
... cells. Upon ectopic expression in axial cells, has2 causes the formation of supernumerary lamellipodia and a blockage of axis extension. Epistasis analyses with constitutively active and dominant-negative versions of the small GTPase Rac1 suggest that HA acts by Rac1 activation, rather than...
Journal Articles
Journal: Development
Development (2003) 130 (22): 5543–5552.
Published: 15 November 2003
...-of-function mutations increased the number of higher-order dendritic branches. Conversely, overexpression of Fmr1 in DA neurons dramatically decreased dendritic branching. In dissecting the mechanisms underlying Fmr1 function in dendrite development, we found that the mRNA encoding small GTPase Rac1...