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Keywords: RNA-binding protein
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Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2021) 148 (1): dev191916.
Published: 11 January 2021
...Danelle Wright; Makoto Kiso; Yumiko Saga ABSTRACT NANOS2 and NANOS3 are evolutionarily conserved RNA-binding proteins involved in murine germ cell development. NANOS3 is required for protection from apoptosis during migration and gonadal colonization in both sexes, whereas NANOS2 is male-specific...
Includes: Supplementary data
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Reproductive biology
Journal: Development
Development (2019) 146 (2): dev168963.
Published: 18 January 2019
... Summary: IMP regulates Notch signalling in follicle cells by controlling Kuzbanian localisation to the apical domain, where Notch cleavage occurs, revealing a novel regulatory step in the Notch pathway. RNA-binding protein Delta ADAM10 protease Drosophila oogenesis RNA-binding proteins...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2016) 143 (24): 4643–4653.
Published: 15 December 2016
..., directly binds dynein light chain DLC-1, regulating FBF-2 localization and activity in a dynein motor-independent manner. Germline Post-transcriptional regulation RNA-binding protein Stem cells LC8 family proteins Translational control is essential for numerous processes in development...
Includes: Supplementary data
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Neural development
Journal: Development
Development (2016) 143 (15): 2753–2759.
Published: 1 August 2016
... specific subsets of mRNAs that are locally translated and have roles in axon pathfinding. However, the RNA-binding proteins involved in axon pathfinding, and their corresponding mRNA targets, are still largely unknown. Here we find that the RNA-binding protein IMP2 (Igf2bp2) is strikingly enriched...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (14): 2397–2404.
Published: 15 July 2015
...Jennifer Tsialikas; Jennifer Romer-Seibert LIN28 is an RNA-binding protein that is best known for its roles in promoting pluripotency via regulation of the microRNA let-7. However, recent studies have uncovered new roles for LIN28 and have revealed how it functions, suggesting that it is more than...
Journal Articles
Journal: Development
Development (2015) 142 (5): 858–870.
Published: 1 March 2015
...Laurence A. Lemaire; Joan Goulley; Yung Hae Kim; Solenne Carat; Patrick Jacquemin; Jacques Rougemont; Daniel B. Constam; Anne Grapin-Botton In human, mutations in bicaudal C1 (BICC1), an RNA binding protein, have been identified in patients with kidney dysplasia. Deletion of Bicc1 in mouse leads...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2012) 139 (19): 3553–3560.
Published: 1 October 2012
...Takaaki Matsui; Akihiro Sasaki; Naoko Akazawa; Hifumi Otani; Yasumasa Bessho RNA-binding proteins (RBPs) bind to numerous and diverse mRNAs to control gene expression post-transcriptionally, although the in vivo functions of specific RBP-mRNA interactions remain largely unknown. Here, we show...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2010) 137 (6): 891–900.
Published: 15 March 2010
...Erica Balzer; Christian Heine; Qiang Jiang; Vivian M. Lee; Eric G. Moss LIN28 is an RNA-binding protein that is expressed in many developing tissues. It can block let-7 ( Mirlet7 ) microRNA processing and help promote pluripotency. We have observed LIN28 expression in the developing mouse neural...
Journal Articles
Journal Articles
Journal: Development
Development (2008) 135 (10): 1803–1812.
Published: 15 May 2008
... is the earliest known molecular event specific to the germline founder cell P 4 . Cis-elements in nos-2 3′UTR have been shown to mediate translational control; however, the trans-acting proteins are not known. Here, we provide evidence that four maternal RNA-binding proteins, OMA-1, OMA-2, MEX-3 and SPN-4, bind...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (13): 3035–3045.
Published: 1 July 2004
...Young J. Yoon; Kimberly L. Mowry RNA localization is a key mechanism for generating cell and developmental polarity in a wide variety of organisms. We have performed studies to investigate a role for the Xenopus homolog of the double-stranded RNA-binding protein, Staufen, in RNA localization during...
Journal Articles
Journal: Development
Development (2003) 130 (11): 2495–2503.
Published: 1 June 2003
... identified an RNP-type RNA-binding protein, SPN-4, as a POS-1-interacting protein. SPN-4 is present developmentally from the oocyte to the early embryo and its distribution overlaps with that of POS-1 in the cytoplasm and P granules of the posterior blastomeres. SPN-4 binds to a subregion of the temporal...
Journal Articles
Journal: Development
Development (2002) 129 (3): 747–759.
Published: 1 February 2002
.... 2002 Caenorhabditis elegans Pattern formation Polarity RNA-binding protein Translational control A central question in developmental biology is how cells first acquire polarity and then use that polarity to produce daughter cells with distinct patterns of gene expression. In C...