...Rebecca Chowdhury; Yue Wang; Melissa Campbell; Susan K. Goderie; Francis Doyle; Scott A. Tenenbaum; Gretchen Kusek; Thomas R. Kiehl; Suraiya A. Ansari; Nathan C. Boles; Sally Temple ABSTRACT STAU2 is a double-stranded RNA-binding protein enriched in the nervous system. During asymmetric divisions...

...Danelle Wright; Makoto Kiso; Yumiko Saga ABSTRACT NANOS2 and NANOS3 are evolutionarily conserved RNA-binding proteins involved in murine germ cell development. NANOS3 is required for protection from apoptosis during migration and gonadal colonization in both sexes, whereas NANOS2 is male-specific...

... and progenitors. Here, using mouse models, we explored the role of RNA-binding proteins (RBPs) in regulation of the biological activities of this population. Proteins bound to polyadenylated RNAs in primary cultures of undifferentiated spermatogonia were captured with oligo (dT)-conjugated beads after UV...

... Summary: IMP regulates Notch signalling in follicle cells by controlling Kuzbanian localisation to the apical domain, where Notch cleavage occurs, revealing a novel regulatory step in the Notch pathway. RNA-binding protein Delta ADAM10 protease Drosophila oogenesis RNA-binding proteins...

..., with the exception of those of the mushroom body (MB), are decommissioned by the ecdysone receptor and mediator complex, causing them to shrink during metamorphosis, followed by nuclear accumulation of Prospero and cell cycle exit. Here, we demonstrate that the levels of Imp and Syp RNA-binding proteins regulate NB...

..., directly binds dynein light chain DLC-1, regulating FBF-2 localization and activity in a dynein motor-independent manner. Germline Post-transcriptional regulation RNA-binding protein Stem cells LC8 family proteins Translational control is essential for numerous processes in development...

...Piero Sanfilippo; Peter Smibert; Hong Duan; Eric C. Lai Drosophila Elav is the founding member of the conserved family of Hu RNA-binding proteins (RBPs), which play crucial and diverse roles in post-transcriptional regulation. Elav has long served as the canonical neuronal marker. Surprisingly...

... specific subsets of mRNAs that are locally translated and have roles in axon pathfinding. However, the RNA-binding proteins involved in axon pathfinding, and their corresponding mRNA targets, are still largely unknown. Here we find that the RNA-binding protein IMP2 (Igf2bp2) is strikingly enriched...

...Jennifer Tsialikas; Jennifer Romer-Seibert LIN28 is an RNA-binding protein that is best known for its roles in promoting pluripotency via regulation of the microRNA let-7. However, recent studies have uncovered new roles for LIN28 and have revealed how it functions, suggesting that it is more than...

...Laurence A. Lemaire; Joan Goulley; Yung Hae Kim; Solenne Carat; Patrick Jacquemin; Jacques Rougemont; Daniel B. Constam; Anne Grapin-Botton In human, mutations in bicaudal C1 (BICC1), an RNA binding protein, have been identified in patients with kidney dysplasia. Deletion of Bicc1 in mouse leads...

... system (CNS). We show that the pan-neural RNA-binding protein (RBP) ELAV (Hu antigen) regulates the RNA processing patterns of the Hox gene Ultrabithorax ( Ubx ) within the embryonic CNS. Using a combination of biochemical, genetic and imaging approaches we demonstrate that ELAV binds to discrete...

...Takaaki Matsui; Akihiro Sasaki; Naoko Akazawa; Hifumi Otani; Yasumasa Bessho RNA-binding proteins (RBPs) bind to numerous and diverse mRNAs to control gene expression post-transcriptionally, although the in vivo functions of specific RBP-mRNA interactions remain largely unknown. Here, we show...

... and temporally, the Hh signaling pathway needs to be precisely regulated at different levels, but only a few factors external to the pathway have been described. Here, we report for the first time the role of the STAR family RNA-binding protein Quaking A (QkA) in somite muscle development. We show in zebrafish...

...Erica Balzer; Christian Heine; Qiang Jiang; Vivian M. Lee; Eric G. Moss LIN28 is an RNA-binding protein that is expressed in many developing tissues. It can block let-7 ( Mirlet7 ) microRNA processing and help promote pluripotency. We have observed LIN28 expression in the developing mouse neural...

...Hitomi Takada; Takahiro Kawana; Yuzuru Ito; Reiko F. Kikuno; Hiroshi Mamada; Toshiyuki Araki; Hisashi Koga; Makoto Asashima; Masanori Taira Post-transcriptional control by RNA-binding proteins is a precise way to assure appropriate levels of gene expression. Here, we identify a novel mRNA...

... is the earliest known molecular event specific to the germline founder cell P 4 . Cis-elements in nos-2 3′UTR have been shown to mediate translational control; however, the trans-acting proteins are not known. Here, we provide evidence that four maternal RNA-binding proteins, OMA-1, OMA-2, MEX-3 and SPN-4, bind...

...Young J. Yoon; Kimberly L. Mowry RNA localization is a key mechanism for generating cell and developmental polarity in a wide variety of organisms. We have performed studies to investigate a role for the Xenopus homolog of the double-stranded RNA-binding protein, Staufen, in RNA localization during...

... identified an RNP-type RNA-binding protein, SPN-4, as a POS-1-interacting protein. SPN-4 is present developmentally from the oocyte to the early embryo and its distribution overlaps with that of POS-1 in the cytoplasm and P granules of the posterior blastomeres. SPN-4 binds to a subregion of the temporal...

.... 2002 Caenorhabditis elegans Pattern formation Polarity RNA-binding protein Translational control A central question in developmental biology is how cells first acquire polarity and then use that polarity to produce daughter cells with distinct patterns of gene expression. In C...

...Douglas W. Houston; Mary Lou King ABSTRACT Xdazl is an RNA component of Xenopus germ plasm and encodes an RNA-binding protein that can act as a functional homologue of Drosophila boule. boule is required for entry into meiotic cell division during fly spermatogenesis. Both Xdazl and boule...