... and glial cells that make up the mature brain. Proneural genes have well-characterised roles in promoting neural cell differentiation and subtype specification, but they also regulate the timing of identity transitions through poorly understood mechanisms. Here, we investigated how the highly related...

...Gemma Sian Richards; Fabian Rentzsch Notch signalling, SoxB and Group A bHLH ‘proneural’ genes are conserved regulators of the neurogenic program in many bilaterians. However, the ancestry of their functions and interactions is not well understood. We address this question in the sea anemone...

...Bonny B. Millimaki; Elly M. Sweet; Mary S. Dhason; Bruce B. Riley Hair cells of the inner ear develop from an equivalence group marked by expression of the proneural gene Atoh1 . In mouse, Atoh1 is necessary for hair cell differentiation, but its role in specifying the equivalence group (proneural...

... at the Drosophila wing margin have been reported to be unaffected by mutations that remove Achaete and Scute function. Indeed, the proneural gene(s) for these organs is not known. Here, we show that the zinc-finger transcription factor Senseless, together with Daughterless, plays the proneural role for the wing...

...Julianna Kele; Nicolas Simplicio; Anna L. M. Ferri; Helena Mira; François Guillemot; Ernest Arenas; Siew-Lan Ang Proneural genes are crucial regulators of neurogenesis and subtype specification in many areas of the nervous system; however, their function in dopaminergic neuron development...

...E. Andersson; J. B. Jensen; M. Parmar; F. Guillemot; A. Björklund Neurogenin 2 ( Ngn2 ) is a proneural gene involved in neuronal differentiation and subtype specification in various regions of the nervous system. In the ventral midbrain, Ngn2 is expressed in a spatiotemporal pattern...

... of neurogenesis many cell cycles later, thereby potentially coordinating axial patterning with control of neuron number and cell fate. * Author for correspondence (e-mail: jnk@phy.ucsf.edu ) 22 3 2005 ©2005. 2005 Zebrafish ath5 ( atoh7 ) Proneural genes Atonal Sonic Hedgehog...

...Luis M. Escudero; Eva Caminero; Karen L. Schulze; Hugo J. Bellen; Juan Modolell The proneural genes achaete ( ac ) and scute ( sc ) are necessary for the formation of the external sensory organs(SOs) of Drosophila . ac and sc are expressed in proneural clusters and impart their cells with neural...

... strongly promotes neural differentiation. We also showed a similar function during primary neurogenesis. Consistent with this proneural effect, we found that in the open neural plate Xseb4R expression is upregulated by the proneural gene XNgnr1 , as well as by the differentiation gene XNeuroD...

...Rolf Urbach; Ralf Schnabel; Gerhard M. Technau In the Drosophila embryo, studies on CNS development have so far mainly focused on the relatively simply structured ventral nerve cord. In the trunk, proneural genes become expressed in small cell clusters at specific positions of the ventral...

... that the myriapod pattern of neural precursor formation is compatible with the possibility of a chelicerate-myriapod sister group relationship. * Author for correspondence (e-mail: angelika.stollewerk@uni-koeln.de ) 18 2 2003 © 2003. 2003 Proneural genes Neurogenic genes Neurogenesis...

... inappropriate levels of Ngn1 protein that upregulate genes normally activated by other bHLH genes. This interpretation is consistent with results from two studies in flies of misexpressed atonal ( ato ), a proneural gene required in chordotonal organs (CHO), but not external sensory organs (ESO). Surprisingly...

... through the activity of the proneural genes. We demonstrate that both signalling and responsive cells are set aside in each tubule primordium from a proneural gene-expressing cluster of cells, in a two-step process. First, a proneural cluster develops within the domain of Wingless-activated, pointedP2...

... phalangioides , and appears thus to be conserved at least among the Araneae. We have identified two basic helix-loop-helix encoding genes – CsASH1 and CsASH2 – that share sequence similarities with proneural genes from other species. Functional analysis of the genes by double-stranded RNA interference revealed...

...Joaquim Culí; Enrique Martín-Blanco; Juan Modolell ABSTRACT An early step in the development of the large mesothoracic bristles (macrochaetae) of Drosophila is the expression of the proneural genes of the achaete-scute complex (AS-C) in small groups of cells (proneural clusters) of the wing...

... an increase in differentiated bipolar cells. Directed expression of Math5 , but not Xath5 , in Xenopus blastomeres produced an expanded retinal phenotype. We propose that Math5 acts as a proneural gene, but has properties different from its most closely related vertebrate family member, Xath5 . A new...

...Patrick Blader; Nadine Fischer; Gerard Gradwohl; François Guillemot; Uwe Strähle ABSTRACT Zebrafish neurogenin1 encodes a basic helix-loop-helix protein which shares structural and functional characteristics with proneural genes of Drosophila melanogaster. neurogenin1 is expressed in the early...

...Mehmet E. Dokucu; S. Lawrence Zipursky; Ross L. Cagan ABSTRACT In the developing Drosophila retina, the proneural gene for photoreceptor neurons is atonal , a basic helix-loop-helix transcription factor. Using atonal as a marker for proneural maturation, we examine the stepwise resolution...

... 1996 by Company of Biologists 1996 neurogenic genes proneural genes primary neurons XASH-3 NeuroD MASH-1, XASH-1 , and XASH-3 are basic helix-loop-helix (bHLH) transcription factors that were identified on the basis of sequence similarity to the Drosophila proneural genes...

... that the complex affects gliogenesis indirectly. These observations lead to the hypothesis that glio-genesis is induced by the presence of sensory organ cells, either the precursor or its progeny. 03 11 1994 © 1995 by Company of Biologists 1995 proneural genes gliogenesis PNS Drosophila...