...Krista M. Angileri; Nornubari A. Bagia; Cedric Feschotte ABSTRACT Tissue regeneration requires precise temporal control of cellular processes such as inflammatory signaling, chromatin remodeling and proliferation. The combination of these processes forms a unique microenvironment permissive...

... produced fewer ENCCs localized along the gut, and these ENCCs failed to reach the hindgut, resulting in HSCR-like phenotypes. Specifically, we observed a proliferation-dependent migration mechanism, where cell divisions were associated with inter-cell distances and migration speed. Lastly, we detected...

... Toulouse Midi-Pyrénées ANR-11-IDEX-02 Building a multicellular functional organ requires tight coordination between cell proliferation, cell fate specification and differentiation. In the developing nervous system, the spatiotemporal regulation of these processes is of key importance...

...André Rosa; Wolfgang Giese; Katja Meier; Silvanus Alt; Alexandra Klaus-Bergmann; Lowell T. Edgar; Eireen Bartels-Klein; Russell T. Collins; Anna Szymborska; Baptiste Coxam; Miguel O. Bernabeu; Holger Gerhardt ABSTRACT Endothelial cell migration and proliferation are essential for the establishment...

... in bipotent Schwann cell precursors during a specific developmental window induces Mitf and represses FoxD3 to promote melanoblast cell fate at the expense of Schwann cells in limbs. Pigmentation Cell fate Determination Proliferation Mitf FoxD3 Mouse Ligue Contre le Cancer http...

...Hessel Honkoop; Phong D. Nguyen; Veronique E. M. van der Velden; Katharina F. Sonnen; Jeroen Bakkers ABSTRACT Zebrafish are excellent at regenerating their heart by reinitiating proliferation in pre-existing cardiomyocytes. Studying how zebrafish achieve this holds great potential in developing new...

.... In contrast, cartilage overgrowth and scoliosis are absent in rare viable nkx3.2 knockdown animals that lack jaw joints, supporting post-embryonic roles for Nkx3.2. Single-cell RNA-sequencing and in vivo validation reveal increased proliferation and upregulation of stress-induced pathways, including...

.... ( 2000 ). Loss of FBP function arrests cellular proliferation and extinguishes c-myc expression . EMBO J.   19 , 1034 - 1044 . 10.1093/emboj/19.5.1034 Hutvagner , G. and Simard , M. J. ( 2008 ). Argonaute proteins: key players in RNA silencing . Nat. Rev. Mol. Cell Biol.   9 , 22...

...Zhen Shi; Cindy Lim; Vuong Tran; Kairong Cui; Keji Zhao; Xin Chen ABSTRACT The Drosophila male germline stem cell (GSC) lineage provides a great model to understand stem cell maintenance, proliferation, differentiation and dedifferentiation. Here, we use the Drosophila GSC lineage to systematically...

... generation by negatively regulating oligodendrocyte precursor cell (OPC) proliferation. GDE3 inhibits OPC proliferation by stimulating ciliary neurotrophic factor (CNTF)-mediated signaling through release of CNTFRα, the ligand-binding component of the CNTF-receptor multiprotein complex, which can function...

...Raz Ben-Yair; Vincent L. Butty; Michele Busby; Yutong Qiu; Stuart S. Levine; Alon Goren; Laurie A. Boyer; C. Geoffrey Burns; Caroline E. Burns ABSTRACT Deciphering the genetic and epigenetic regulation of cardiomyocyte proliferation in organisms that are capable of robust cardiac renewal...

... levels of GATAe gene expression in tubule principal cells induce uncontrolled cell proliferation, resulting in tumorous growth with associated altered expression of apoptotic and carcinogenic key genes. Furthermore, we uncover the involvement of GATAe in the maintenance of stellate cells and migration...

... is essential for cardiomyocyte proliferation and cardiogenesis. Mosaic Myc overexpression in a Mycn -deficient background shows that Myc can replace Mycn function, recovering heart development. We further show that this recovery involves the elimination of Mycn-deficient cells by cell competition. Our results...

... and highlighting JAK/STAT pathway functions in proliferation, survival and cell competition that are conserved between Drosophila and vertebrates. upd continues to be produced by niche cells in the adult testis but declines with age ( Kiger et al., 2001 ; Toledano et al., 2012 ; Tulina and Matunis, 2001...

.... Here, we study how increased cell number evolved in the vertebrate central nervous system, investigating the regulation of cell proliferation in the lamprey spinal cord. Markers of proliferation show that a ventricular progenitor zone is found throughout the lamprey spinal cord. We show that inhibition...

... that Cdc42 is required for endothelial tip cell selection, directed cell migration and filopodia formation, but dispensable for cell proliferation or apoptosis. Although the loss of Cdc42 seems generally compatible with apical-basal polarization and lumen formation in retinal blood vessels, it leads...

..., proliferation and survival of glial precursors. Both the switch from neurogenesis to gliogenesis and the subsequent glial expansion depend on Notch signaling. Taken together, lineage origins preconfigure the development of individual glial precursors with involvement of serial Notch actions in promoting...

... hormone 20-hydroxyecdysone (20E) in the maintenance of numerous patterning systems in vivo and in explant culture. We find that low concentrations of 20E support prolonged proliferation in explanted wing discs in the absence of insulin, incidentally providing novel insight into the hormonal regulation...

... and tissue movements during elongation. We quantify the tissue-specific contribution to axis elongation using 3D volumetric techniques, then quantify tissue-specific parameters such as cell density and proliferation. To study cell behavior at a multi-tissue scale, we used high-resolution 4D imaging...

... by cell-cell sorting analyses. However, we demonstrate that only the earlier autopod cells can adopt the host proliferation rate to permit normal morphogenesis. Therefore, our findings reveal that the ability of embryonic cells to differentially reset their intrinsic behaviours confers robustness to limb...