....118.300223 Benmimoun , B. , Polesello , C. , Waltzer , L. and Haenlin , M. ( 2012 ). Dual role for Insulin/TOR signaling in the control of hematopoietic progenitor maintenance in Drosophila . Development 139 , 1713 - 1717 . 10.1242/dev.080259 Benmimoun , B...

.... Here, we demonstrate that a restricted pool of progenitors in the mouse spinal cord, expressing the transcription factor Dbx1, produces a subset of astrocytes, in addition to interneurons. Ventral p0-derived astrocytes (vA0 cells) exclusively populate intermediate regions of spinal cord...

...Matthew J. Shannon; Jennet Baltayeva; Barbara Castellana; Jasmin Wächter; Gina L. McNeill; Ji Soo Yoon; Jenna Treissman; Hoa T. Le; Pascal M. Lavoie; Alexander G. Beristain ABSTRACT In early placental development, progenitor cytotrophoblasts (CTB) differentiate along one of two cellular...

...Charles J. Sheehan; John J. McMahon; Lucas D. Serdar; Debra L. Silver ABSTRACT Embryonic interneuron development underlies cortical function and its disruption contributes to neurological disease. Yet the mechanisms by which viable interneurons are produced from progenitors remain poorly understood...

...Thomas Volckaert; Tingting Yuan; Jie Yuan; Eistine Boateng; Seantel Hopkins; Jin-San Zhang; Victor J. Thannickal; Reinhard Fässler; Stijn P. De Langhe ABSTRACT Organ growth and tissue homeostasis rely on the proliferation and differentiation of progenitor cell populations. In the developing lung...

...Eric D. Bankaitis; Matthew E. Bechard; Guoqiang Gu; Mark A. Magnuson; Christopher V. E. Wright ABSTRACT During mouse pancreas organogenesis, endocrine cells are born from progenitors residing in an epithelial plexus niche. After a period in a lineage-primed Neurog3 LO state, progenitors become...

... that the original work is properly attributed. Summary: This Review describes how recent technological advances have shed light on the mechanisms underlying human lung development and disease, and outlines the future challenges in this field. Bronchi Alveolar ESC iPSC Progenitor Stem cell Lung...

... progenitors. We identify a proliferative trophoblast niche at the base of the cytotrophoblast cell columns in first trimester placentas that is characterised by integrin α2 (ITGA2) expression. Pulse-chase experiments with 5-iodo-2′-deoxyuridine indicate that these cells might contribute to both villous (VCT...

...Shawn Liang; Ellen Johansson; Guillermo Barila; Daniel L. Altschuler; Henrik Fagman; Mikael Nilsson ABSTRACT The developmental program that regulates thyroid progenitor cell proliferation is largely unknown. Here, we show that branching-like morphogenesis is a driving force to attain final size...

...Zhanguo Gao; Alexes C. Daquinag; Fei Su; Brad Snyder; Mikhail G. Kolonin The relative abundance of thermogenic beige adipocytes and lipid-storing white adipocytes in adipose tissue underlie its metabolic activity. The roles of adipocyte progenitor cells, which express PDGFRα or PDGFRβ, in adipose...

... airway epithelial homeostasis in mice, FGFR2 signalling is required for self-renewing divisions of basal stem cells and to maintain expression of the key transcription factor SOX2. Cre-Lox Lung Mouse Trachea Progenitor Like human airways, the mouse trachea contains three major...

...Aileen R. Helsel; Qi-En Yang; Melissa J. Oatley; Tessa Lord; Fred Sablitzky; Jon M. Oatley Spermatogenesis is a classic model of cycling cell lineages that depend on a balance between stem cell self-renewal for continuity and the formation of progenitors as the initial step in the production...

.... Somatic deletion of Sip1 from mouse retinal progenitors primarily affects the generation of inner nuclear layer cell types, resulting in complete loss of horizontal cells and reduced numbers of amacrine and bipolar cells, while the number of Muller glia is increased. Molecular analysis places Sip1...

...Sam Goldsmith; Robin Lovell-Badge; Karine Rizzoti Sox2 mutations are associated with pituitary hormone deficiencies and the protein is required for pituitary progenitor proliferation, but its function has not been well characterized in this context. SOX2 is known to activate expression of Six6...

...Christopher P. Zelinka; Leo Volkov; Zachary A. Goodman; Levi Todd; Isabella Palazzo; William A. Bishop; Andy J. Fischer We investigate the roles of mTor signaling in the formation of Müller glia-derived progenitor cells (MGPCs) in the chick retina. During embryonic development, pS6 (a readout...

... of Biologists Ltd 2015 SUMMARY : This poster article summarises how lysophosphatidic acid is produced and metabolised during development, how it signals, and how it influences tissue and organ development. Lysophospholipid GPCR Progenitor Proliferation Differentiation Survival Migration...

...Michael A. Trembley; Lissette S. Velasquez; Karen L. de Mesy Bentley; Eric M. Small An important pool of cardiovascular progenitor cells arises from the epicardium, a single layer of mesothelium lining the heart. Epicardium-derived progenitor cell (EPDC) formation requires epithelial-to-mesenchymal...

...Daniela Später; Emil M. Hansson; Lior Zangi; Kenneth R. Chien During development, cardiogenesis is orchestrated by a family of heart progenitors that build distinct regions of the heart. Each region contains diverse cell types that assemble to form the complex structures of the individual cardiac...

...Philip A. Seymour; Hung Ping Shih; Nisha A. Patel; Kristine K. Freude; Ruiyu Xie; Christopher J. Lim; Maike Sander All mature pancreatic cell types arise from organ-specific multipotent progenitor cells. Although previous studies have identified cell-intrinsic and -extrinsic cues for progenitor...

...Ethan David Cohen; Mayumi F. Miller; Zichao Wang; Randall T. Moon; Edward E. Morrisey Wnt/β-catenin has a biphasic effect on cardiogenesis, promoting the induction of cardiac progenitors but later inhibiting their differentiation. Second heart field progenitors and expression of the second heart...