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Keywords: Primordial germ cells
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Reproductive biology
Journal: Development
Development (2023) 150 (17): dev202046.
Published: 31 August 2023
.... Male germ cell development starts when pluripotent cells undergo specification to sexually uncommitted primordial germ cells, which act as precursors of both oocytes and spermatozoa. Male-specific development subsequently occurs in the fetal testes, resulting in the formation of spermatogonial stem...
Journal Articles
Journal: Development
Development (2022) 149 (21): dev200920.
Published: 7 November 2022
...-1746891 National Institutes of Health http://dx.doi.org/10.13039/100000002 R37HD037047 T32 GM007445 Germ plasm P-bodies Germline Primordial germ cells RNP granules C. elegans Highlighted Article: This paper describes a new condensate in the C. elegans germ plasm...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (4): dev200319.
Published: 18 February 2022
...Yuki Naitou; Go Nagamatsu; Nobuhiko Hamazaki; Kenjiro Shirane; Masafumi Hayashi; Makoto Hayashi; Satoru Kobayashi; Katsuhiko Hayashi ABSTRACT In mammals, primordial germ cells (PGCs), the origin of the germ line, are specified from the epiblast at the posterior region where gastrulation...
Includes: Supplementary data
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Journal: Development
Development (2021) 148 (6): dev189217.
Published: 15 March 2021
...Grace V. Hancock; Sissy E. Wamaitha; Lior Peretz; Amander T. Clark ABSTRACT The peri-implantation window of mammalian development is the crucial window for primordial germ cell (PGC) specification. Whereas pre-implantation dynamics are relatively conserved between species, the implantation window...
Journal Articles
Journal: Development
Development (2019) 146 (10): dev168427.
Published: 15 May 2019
...Tzofia Bialistoky; Diane Manry; Peyton Smith; Christopher Ng; Yunah Kim; Sol Zamir; Victoria Moyal; Rachel Kalifa; Paul Schedl; Offer Gerlitz; Girish Deshpande ABSTRACT During embryonic gonad coalescence, primordial germ cells (PGCs) follow a carefully choreographed migratory route circumscribed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (20): dev170209.
Published: 17 October 2018
..., OCT4 and PRDM14, in mouse embryonic stem cells, epiblast-like cells and primordial germ cell-like cells (PGCLCs). PGCLCs are an important system for elucidating primordial germ cell development in mice. We monitored PRDM14 binding during the specification of PGCLCs, identifying direct targets of PRDM14...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (16): dev150433.
Published: 23 July 2018
...Toshihiro Kobayashi; M. Azim Surani ABSTRACT In mice, primordial germ cells (PGCs), the precursors of eggs and sperm, originate from pregastrulation postimplantation embryos. By contrast, the origin of human PGCs (hPGCs) has been less clear and has been difficult to study because of the technical...
Journal Articles
Journal: Development
Development (2017) 144 (7): 1201–1210.
Published: 1 April 2017
...Nathalie Oulhen; S. Zachary Swartz; Jessica Laird; Alexandra Mascaro; Gary M. Wessel Stem cells in animals often exhibit a slow cell cycle and/or low transcriptional activity referred to as quiescence. Here, we report that the translational activity in the primordial germ cells (PGCs) of the sea...
Includes: Supplementary data
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Journal Articles
Journal: Development
Development (2016) 143 (12): 2111–2120.
Published: 15 June 2016
...Girish Deshpande; Diane Manry; Nicholas Jourjine; Vladic Mogila; Henny Mozes; Tzofia Bialistoky; Offer Gerlitz; Paul Schedl Coalescence of the embryonic gonad in Drosophila melanogaster requires directed migration of primordial germ cells (PGCs) towards somatic gonadal precursor cells (SGPs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (20): 3571–3582.
Published: 15 October 2015
...Rana Mainpal; Jeremy Nance; Judith L. Yanowitz Despite the central importance of germ cells for transmission of genetic material, our understanding of the molecular programs that control primordial germ cell (PGC) specification and differentiation are limited. Here, we present findings that X...
Includes: Supplementary data
Journal Articles
Journal: Development
Series: Primer Series
Development (2014) 141 (2): 245–252.
Published: 15 January 2014
...Erna Magnúsdóttir; M. Azim Surani Primordial germ cells (PGCs) are the precursors of sperm and eggs, which generate a new organism that is capable of creating endless new generations through germ cells. PGCs are specified during early mammalian postimplantation development, and are uniquely...
Journal Articles
Journal Articles
Journal: Development
Development (2013) 140 (12): 2495–2501.
Published: 15 June 2013
.... Furthermore, primordial germ cells express, and appear to be functionally dependent upon, transcription factors that characterise the pluripotent state. We hypothesise that germ cells require pluripotency factors to control a de-restricted epigenome. Consequently, they harbour latent potential, as manifested...
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