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Keywords: Primitive streak
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Journal Articles
Journal: Development
Development (2022) 149 (10): dev200295.
Published: 16 May 2022
... these. Using experimental manipulation of early chick embryos, including misexpression of an inducer (VG1 or ACTIVIN) and an inhibitor (BMP4), we test two alternative models for their ability to explain how the site of primitive streak formation is positioned relative to the rest of the embryo. In one model...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (4): dev180612.
Published: 16 February 2021
... and regenerative medicine. Axis elongation Gastrulation Neuromesodermal progenitors Primitive streak Tail bud Pluripotent stem cells Lineage specification in the early vertebrate embryo is initiated during gastrulation (see Glossary, Box 1 ), which involves the formation of the three germ...
Journal Articles
Journal: Development
Development (2020) 147 (3): dev175109.
Published: 4 February 2020
... of chick embryos in the early stages of primitive streak formation. Junctional tension of mesendoderm precursors in the epiblast is higher in junctions oriented in the direction of intercalation than in junctions oriented perpendicular to the direction of intercalation and higher than in junctions of other...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (17): dev179564.
Published: 12 September 2019
...Iain Martyn; Eric D. Siggia; Ali H. Brivanlou ABSTRACT Although fate maps of early embryos exist for nearly all model organisms, a fate map of the gastrulating human embryo remains elusive. Here, we use human gastruloids to piece together a rudimentary fate map for the human primitive streak (PS...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (4): dev161075.
Published: 23 February 2018
..., it binds a gene cohort involved in primitive streak formation at gastrulation, including NODAL , BMP4 and WNT3 . Comparing TCF7L1-bound sites with those bound by the WNT signaling effector β-catenin indicates that TCF7L1 acts largely on the WNT signaling pathway. TCF7L1 overlaps less with the pluripotency...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (1): 92–98.
Published: 1 January 2015
..., such as the circular blastopore of amphibians, the straight primitive streak of birds and mammals or in intermediate gastrulation forms of other amniotes such as reptiles. Planar cell movements are prime candidates to arrange specific modes of gastrulation but there is no consensus view on their role in different...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (6): 1209–1221.
Published: 15 March 2014
... by their position. Cell fate is progressively restricted by localised signalling cues from areas including the primitive streak. However, it is unknown whether this restriction accompanies, at the individual cell level, a reduction in potency. Investigation of these early transition events in vitro is possible via...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (13): 2691–2696.
Published: 1 July 2013
...Cantas Alev; Yuping Wu; Yukiko Nakaya; Guojun Sheng Mesoderm is formed during gastrulation. This process takes place at the blastopore in lower vertebrates and in the primitive streak (streak) in amniotes. The evolutionary relationship between the blastopore and the streak is unresolved...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (8): 1665–1675.
Published: 15 April 2013
...-dimensional body plan during gastrulation. In Tcf7l1 -/- embryos, specification of mesoderm is delayed, effectively uncoupling it from the induction of the primitive streak. Tcf7l1 repressor activity is necessary for a rapid switch in the response of pluripotent cells to Wnt/β-catenin stimulation, from one...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (18): 3343–3354.
Published: 15 September 2012
... of the primitive streak. Formation of an ectopic primitive streak, or streak expansion, has previously been reported in mutants lacking antagonists that target Nodal signaling. Here, we demonstrate that loss-of-function of a major bone morphogenetic protein (BMP) effector, Smad5, results in formation of an ectopic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (17): 2863–2874.
Published: 1 September 2010
...Cantas Alev; Yuping Wu; Takeya Kasukawa; Lars M. Jakt; Hiroki R. Ueda; Guojun Sheng In birds and mammals, all mesoderm cells are generated from the primitive streak. Nascent mesoderm cells contain unique dorsoventral (D/V) identities according to their relative ingression position along the streak...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (4): 595–603.
Published: 15 February 2009
..., morphology,and function of the yolk-sac placenta of laboratory rodents. Teratology 41 , 361 -381. Jouve, C., Iimura, T. and Pourquie, O. ( 2002 ). Onset of the segmentation clock in the chick embryo: evidence for oscillations in the somite precursors in the primitive streak. Development 129 , 1107...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (17): 2969–2979.
Published: 1 September 2008
...)-cell self-renewal, such that up to 80% of the hES cells developed into the primitive streak (PS)/mesoderm progenitors, reminiscent of early mammalian embryogenesis. The formation of the PS/mesoderm progenitors essentially depended on the cooperative action of β-catenin together with Activin/Nodal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (15): 2829–2840.
Published: 1 August 2007
...Noemí Cambray; Valerie Wilson In mammals, the primitive streak region and its descendant, the tail bud,are the source of nascent mesoderm and spinal cord throughout axial elongation. A localised population of long-term axial progenitors has been identified in a region of the tail bud...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (19): 3777–3786.
Published: 1 October 2006
...Kunimasa Ohta; Sei Kuriyama; Tatsuya Okafuji; Ryu Gejima; Shin-ichi Ohnuma; Hideaki Tanaka Three classes of signaling molecule, VG1, WNT and BMP, play crucial roles in axis formation in the chick embryo. Although VG1 and WNT signals have a pivotal function in inducing the primitive streak...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (19): 3767–3775.
Published: 1 October 2006
... in mesoderm development. Unlike Bmpr1a -null embryos, which fail to gastrulate, Bmpr-MORE embryos initiate gastrulation, but the recruitment of prospective paraxial mesoderm cells to the primitive streak is delayed. This delay causes a more proximal distribution of cells with paraxial mesoderm character...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (15): 2947–2959.
Published: 1 August 2006
.... * Author for correspondence (e-mail: kdowns@wisc.edu ) 23 5 2005 © 2006. 2006 Allantois Anteroposterior axis Apoptosis Brachyury Primitive streak Patterning Proliferation Vasculogenesis Mouse Yolk sac Heart The evolutionarily conserved T-box family of transcription...
Journal Articles
Journal: Development
Development (2004) 131 (1): 37–55.
Published: 1 January 2004
... placenta. During gastrulation, the allantois grows into the exocoelomic cavity as a mesodermal extension of the posterior primitive streak. On the basis of morphology, gene expression and/or function, three cell types have been identified in the allantois: an outer layer of mesothelial cells, whose distal...
Journal Articles
Journal: Development
Development (2002) 129 (15): 3609–3619.
Published: 1 August 2002
... analysis laacZ Self-renewing cells Stem cell Primitive streak Presomitic mesoderm Segmentation Mouse embryo Clock Patterning A central aspect of vertebrate embryo development is the segmentation and specification of its longitudinal axis ( Keynes and Stern, 1988 ). This segmentation...
Journal Articles
Journal: Development
Development (2002) 129 (10): 2355–2365.
Published: 15 May 2002
... functional analysis. (2) Vital dye (DiI) labelling in vitro suggests that epiblast cells arrive in the PGE from anterior parts of the embryonic disc and then move within this area in a complex pattern of posterior, centripetal and anterior directions to form the primitive streak. (3) BrdU labelling shows...