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Keywords: Presenilin
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Journal Articles
Journal: Development
Development (2013) 140 (4): 810–819.
Published: 15 February 2013
...Diana L. van de Hoef; Julia M. Bonner; Gabrielle L. Boulianne Presenilins were identified as causative factors in familial Alzheimer's disease and also play an essential role in Notch signaling during development. We previously identified FKBP14, a member of the family of FK506-binding proteins...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (20): 5019–5029.
Published: 15 October 2003
...Pei Wang; Fred A. Pereira; Duane Beasley; Hui Zheng Mammalian presenilins consist of two highly homologous proteins, PSEN1 and PSEN2, which share redundant activities in Notch processing and signaling. To bypass the early lethality of the Psen1 - and Psen2 -double(PSEN) null embryos, we used...
Journal Articles
Journal: Development
Development (2003) 130 (18): 4259–4268.
Published: 15 September 2003
... in the rostrocaudal patterning of the somite. We have previously shown that changes in the Mesp2 expression domain from a presumptive one somite into a rostral half somite results in differential activation of two types of Notch pathways, dependent or independent of presenilin 1 (Psen1),which is a Notch signal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (10): 2117–2128.
Published: 15 May 2003
...Bernard Lakowski; Stefan Eimer; Christine Göbel; Andreas Böttcher; Babett Wagler; Ralf Baumeister Mutations in presenilin genes are associated with familial Alzheimer's disease in humans and affect LIN-12/Notch signaling in all organisms tested so far. Loss of sel-12 presenilin activity...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (10): 2225–2238.
Published: 15 May 2003
... that Notch signalling requires Presenilin to modulate this switch. Therefore, Notch signalling inhibits chd expression and this may occur through a direct or indirect regulation and/or by inhibiting the development of the dorsal axial mesoderm. Thus, we studied the effects of activating the Notch pathway...
Journal Articles
Journal: Development
Development (2003) 130 (9): 1973–1988.
Published: 1 May 2003
... the SOP insensitive to Dl. * Author for correspondence (e-mail: th.klein@uni-koeln.de ) 30 1 2003 © 2003. 2003 Suppressor of Hairless Enhancer of split complex Notch-signalling Bristle development Presenilin Kuzbanian Senseless Notch signalling plays a fundamental...