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Anisha Solanki, Diana C. Yánez, Ching-In Lau, Jasmine Rowell, Alessandro Barbarulo, Susan Ross, Hemant Sahni, Tessa Crompton
Development (2020) 147 (19): dev192203.
Published: 7 October 2020
...-positive (DP) cell. Notch signalling is required for T-cell fate specification and must be maintained throughout β-selection, but inappropriate Notch activation in DN4 and DP cells is oncogenic. Here, we show that pre-TCR signalling leads to increased expression of the transcriptional repressor Bcl6...
Includes: Supplementary data