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Keywords: Pre-TCR
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Journal Articles

The transcriptional repressor Bcl6 promotes pre-TCR-induced thymocyte differentiation and attenuates Notch1 activation

Anisha Solanki, Diana C. Yánez, Ching-In Lau, Jasmine Rowell, Alessandro Barbarulo, Susan Ross, Hemant Sahni, Tessa Crompton
Journal: Development
Development (2020) 147 (19): dev192203.
https://doi.org/10.1242/dev.192203
Published: 7 October 2020
...-positive (DP) cell. Notch signalling is required for T-cell fate specification and must be maintained throughout β-selection, but inappropriate Notch activation in DN4 and DP cells is oncogenic. Here, we show that pre-TCR signalling leads to increased expression of the transcriptional repressor Bcl6...
View article titled, The transcriptional repressor Bcl6 promotes <span class="search-highlight">pre</span>-<span class="search-highlight">TCR</span>-induced thymocyte differentiation and attenuates Notch1 activation
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Includes: Supplementary data