...) patterning Developmental genetics Posterior prevalence Vertebral column Primaxial/abaxial Differences in the anteroposterior (AP) patterning of the axial skeleton result in an enormous diversity of body plans in vertebrates. Hox genes were first described in Drosophila for their ability...

... Missense mutation DNA binding Posterior prevalence Hox genes encode a set of highly conserved transcription factors, which control cell fates and regional identities along the primary body axis in all metazoans. Most vertebrates, including humans, have 39 Hox genes arranged in four clusters (Hoxa...

... that prevails, a phenomenon known as posterior prevalence. We use dpp674, a visceral mesoderm-specific enhancer of decapentaplegic ( dpp ), to investigate functional dominance among Hox genes molecularly. We find that posterior prevalence does not adequately describe the regulation of dpp by Hox genes. Instead...

.... Skeletal reductions in the proximal limb may be a consequence of posterior prevalence, whereby proximal misexpression of Hoxd-13 and Hoxd-12 results in the transcriptional and/or functional inactivation of Hox group 11 genes. The Ulnaless digit phenotypes are attributed to a reduction in the distal...