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Keywords: Polycystic kidney disease
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Journal Articles
Journal: Development
Development (2018) 145 (6): dev158931.
Published: 22 March 2018
...Bo Zhang; Uyen Tran; Oliver Wessely ABSTRACT The development of the kidney relies on the establishment and maintenance of a precise tubular diameter of its functional units, the nephrons. This process is disrupted in polycystic kidney disease (PKD), resulting in dilations of the nephron and renal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (7): 1107–1116.
Published: 1 April 2010
... are characterized by the formation of fluid-filled cysts in the kidney and by expansion of epithelial ducts in liver and pancreas. This phenotype is reminiscent of human forms of polycystic kidney disease (PKD). Here, we now provide data that Bicc1 functions by modulating the expression of polycystin 2 (Pkd2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (17): 3019–3030.
Published: 1 September 2009
... 11 6 2009 © 2009. © 2009. 2009 Polycystic kidney disease PCP Flow Nodal SAM domain K-homology In vertebrates, left-right (LR) asymmetry of the visceral situs is established by Nodal signals from the posterior notochord (PNC), also known as the ventral node in mammals...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (14): 3457–3467.
Published: 15 July 2004
...David A. Cano; Noel S. Murcia; Gregory J. Pazour; Matthias Hebrok Polycystic kidney disease (PKD) includes a group of disorders that are characterized by the presence of cysts in the kidney and other organs,including the pancreas. Here we show that in orpk mice, a model system for PKD that harbors...