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Keywords: Polarity
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Journal Articles
Journal: Development
Development (2022) 149 (10): dev200295.
Published: 16 May 2022
... in this paper in a system such as anterior-posterior patterning of the chick limb, which is also large at early stages (HH18-20) and involves a localised signalling region (the Zone of Polarizing Activity) ( Riddle et al., 1993 ; Tickle et al., 1975 ). Here, we propose that positional information (when...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (23): dev200029.
Published: 10 December 2021
... consideration in reconciling conflicting data of the literature. Indeed, immature microvilli in non-polarized cells seem to be more dynamic, i.e. life-cycle of ∼12 min in A6 cells ( Gorelik et al., 2003 ), with intense actin treadmilling (half-time recovery of ezrin of ∼30 s) ( Garbett and Bretscher, 2012...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (11): dev175760.
Published: 4 June 2020
.... The EGF receptor in the nearest VPC sequesters the limiting EGF amounts released by the AC to prevent EGF from spreading to distal VPCs. Here, we show that not only EGFR localization in the VPCs but also EGF polarity in the AC is necessary for robust fate specification. The AC secretes EGF...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (7): dev183954.
Published: 12 April 2020
... for the delamination of chick neural crest cells by promoting the basal positioning of nuclei during EMT, an effect that is independent of its catalytic activity. EMT MMP14 Delamination Mitosis Neural crest Polarity Here, we have used chick NC cells as in vivo model of EMT. NC cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (7): dev183186.
Published: 6 April 2020
... in the regulation of the terminal asymmetric divisions of neuronal progenitors. C. elegans Neuron Asymmetric division Polarity Wnt signalling The nervous system of animals is composed of a high diversity of neuronal subtypes. In vertebrates and invertebrates, neurons are often generated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (3): dev180232.
Published: 3 February 2020
...Cristiano Lucci; Raquel Mesquita-Ribeiro; Alex Rathbone; Federico Dajas-Bailador ABSTRACT Both the establishment of neuronal polarity and axonal growth are crucial steps in the development of the nervous system. The local translation of mRNAs in the axon provides precise regulation of protein...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2019) 146 (23): dev182774.
Published: 9 December 2019
... polarisation, as both follicle and stalk cells localise polarity factors correctly, despite being mispositioned. Instead, loss of integrins causes pre-follicle cells to constrict basally, detach from the basement membrane and become internalised. Thus, integrin function is dispensable for pre-follicle cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (22): dev182188.
Published: 25 November 2019
...Dianna J. Prince; Jason R. Jessen ABSTRACT Lateral zebrafish hypoblast cells initiate dorsal convergence near mid-gastrulation and exhibit non-polarized morphologies, limited cell-cell contact and indirect migration trajectories. By late gastrulation, mesodermal cells become packed as they engage...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (11): dev174508.
Published: 5 June 2019
...Aurélien Bidaud-Meynard; Ophélie Nicolle; Markus Heck; Yann Le Cunff; Grégoire Michaux ABSTRACT Intestine function relies on the strong polarity of intestinal epithelial cells and the array of microvilli forming a brush border at their luminal pole. Combining a genetic RNA interference (RNAi...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (6): dev171116.
Published: 25 March 2019
...Andrew W. Folkmann; Geraldine Seydoux ABSTRACT The MARK/PAR-1 family of kinases are conserved regulators of cell polarity that share a conserved C-terminal kinase-associated domain (KA1). Localization of MARK/PAR-1 kinases to specific regions of the cell cortex is a hallmark of polarized cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (22): dev165472.
Published: 15 November 2018
...Anna M. Love; Dianna J. Prince; Jason R. Jessen ABSTRACT During zebrafish gastrulation the planar cell polarity (PCP) protein Vang-like 2 (Vangl2) regulates the polarization of cells that are engaged in directed migration. However, it is unclear whether Vangl2 influences membrane-protrusive...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (21): dev163105.
Published: 9 November 2018
... reduction of lung size owing to an early arrest of branching morphogenesis. This growth defect is accompanied by abnormalities in epithelial cell polarity, cell division plane and extracellular matrix deposition, as well as precocious and increased expression of markers for type 1 alveolar epithelial cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (4): dev155275.
Published: 23 February 2018
... cells to polarized and tremendously ramified cells. Connexin 30, an astroglial gap-junction channel-forming protein expressed postnatally, regulates in situ the extension and ramification of astroglial processes. However, the involvement of connexin 30 in astroglial polarization, which is known...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (2): dev157941.
Published: 26 January 2018
...Teresa T. Bonello; Kia Z. Perez-Vale; Kaelyn D. Sumigray; Mark Peifer ABSTRACT Epithelial apical-basal polarity drives assembly and function of most animal tissues. Polarity initiation requires cell-cell adherens junction assembly at the apical-basolateral boundary. Defining the mechanisms...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (19): 3511–3520.
Published: 1 October 2017
... developing nephron tubules reveals that cell division is not oriented in the longitudinal (or planar-polarized) axis. However, cell division is oriented perpendicular to the apical-basal axis. Absence of afadin in vivo leads to misorientation of apical-basal cell division in nephron tubules. Together...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (19): 3405–3416.
Published: 1 October 2017
...Charles F. Lang; Edwin Munro PAR proteins constitute a highly conserved network of scaffolding proteins, adaptors and enzymes that form and stabilize cortical asymmetries in response to diverse inputs. They function throughout development and across the metazoa to regulate cell polarity. In recent...
Journal Articles
Journal: Development
Development (2016) 143 (13): 2292–2304.
Published: 1 July 2016
... the Shh signaling response, causing cell cycle exit and differentiation. We tested this hypothesis using genetic and pharmacological manipulation, gene expression analysis and time-lapse imaging of zebrafish embryos. Blocking the function of miR-219, a microRNA that downregulates apical Par polarity...
Journal Articles
In collection:
Plant development
Journal: Development
Development (2016) 143 (12): 2044–2055.
Published: 15 June 2016
... (PIs), also exert regulatory effects. Indeed, emerging evidence indicates that PIs play crucial roles in controlling polarity and growth in plants. Here, I highlight the key roles of PIs as important regulatory membrane lipids in plant development and function. * Author for correspondence...
Journal Articles
Journal: Development
Development (2016) 143 (10): 1663–1673.
Published: 15 May 2016
... mammary gland, Blimp1 marks a rare progenitor population, and is required for cell proliferation and polarity as well as efficient milk production. Blimp1 Prdm1 Transcriptional repressor Mammary gland morphogenesis Luminal progenitors Polarity Lumen formation 3D culture Mouse...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (3): 555–566.
Published: 1 February 2015
...Helen L. May-Simera; Ronald S. Petralia; Mireille Montcouquiol; Ya-Xian Wang; Katherine B. Szarama; Yun Liu; Weichun Lin; Michael R. Deans; Gregory J. Pazour; Matthew W. Kelley Primary cilia have been implicated in the generation of planar cell polarity (PCP). However, variations in the severity...
Includes: Supplementary data