... researchers, ranging from postgraduate students to young group leaders working in developmental and stem cell biology. Here, we summarize the excellent work presented at the Symposium, which covered topics ranging from pluripotency, species-specific aspects of development and emerging technologies, through...

... DNA elements, which are de-repressed in SUV420H2 knockout ES cells. Moreover, SUV420H2 regulation of H4K20me3-marked heterochromatin controls chromatin architecture, including fine-scale chromatin interactions in pluripotent ES cells. Our results indicate that SUV420H2 plays a crucial role...

...Chandrika Rao; Mattias Malaguti; John O. Mason; Sally Lowell ABSTRACT The intrinsic mechanisms that link extracellular signalling to the onset of neural differentiation are not well understood. In pluripotent mouse cells, BMP blocks entry into the neural lineage via transcriptional upregulation...

...Karolina Punovuori; Rosa P. Migueles; Mattias Malaguti; Guillaume Blin; Kenneth G. Macleod; Neil O. Carragher; Tim Pieters; Frans van Roy; Marc P. Stemmler; Sally Lowell ABSTRACT A switch from E- to N-cadherin regulates the transition from pluripotency to neural identity, but the mechanism by which...

... and infertility. We report the differentiation of human pluripotent stem cells into many of the major types of neuropeptidergic hypothalamic neurons, including those producing pro-opiolemelanocortin, agouti-related peptide, hypocretin/orexin, melanin-concentrating hormone, oxytocin, arginine vasopressin...

... and epigenetic inheritance. * Author for correspondence ( leschb@wi.mit.edu ) Competing interests The authors declare no competing financial interests. © 2014. Published by The Company of Biologists Ltd 2014 Poised Bivalent Germ line Germ cell Chromatin Pluripotent Poised...

... by which reprogramming may be experimentally performed: nuclear transfer to eggs or oocytes, cell fusion, extract treatment, direct reprogramming to pluripotency and transdifferentiation. * Author for correspondence ( rph32@cam.ac.uk ) Competing interests statement The authors declare...

...Jong-Won Lim; Pamela Hummert; Jason C. Mills; Kristen L. Kroll Transient maintenance of a pluripotent embryonic cell population followed by the onset of multi-lineage commitment is a fundamental aspect of development. However, molecular regulation of this transition is not well characterized...