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1-20 of 79
Keywords: Pluripotency
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Journal Articles
Katsiaryna Maskalenka, Gökberk Alagöz, Felix Krueger, Joshua Wright, Maria Rostovskaya, Asif Nakhuda, Adam Bendall, Christel Krueger, Simon Walker, Aylwyn Scally, Peter J. Rugg-Gunn
Journal:
Development
Development (2023) 150 (2): dev201155.
Published: 18 January 2023
... overlapping but distinct expression profiles, with high NANOGP1 expression restricted to early epiblast cells and naïve-state pluripotent stem cells. Sequence analysis and epitope-tagging revealed that NANOGP1 is protein coding with an intact homeobox domain. The duplication that created NANOGP1 occurred...
Includes: Supplementary data
Journal Articles
In collection:
Stem cells & regeneration
Journal:
Development
Development (2022) 149 (24): dev200988.
Published: 21 December 2022
...Anish Dattani; Tao Huang; Corin Liddle; Austin Smith; Ge Guo ABSTRACT Propagation of human naïve pluripotent stem cells (nPSCs) relies on the inhibition of MEK/ERK signalling. However, MEK/ERK inhibition also promotes differentiation into trophectoderm (TE). Therefore, robust self-renewal requires...
Includes: Supplementary data
Journal Articles
In collection:
Stem cells & regeneration
Natalia López-Anguita, Seher Ipek Gassaloglu, Maximilian Stötzel, Adriano Bolondi, Deniz Conkar, Marina Typou, René Buschow, Jesse V. Veenvliet, Aydan Bulut-Karslioglu
Journal:
Development
Development (2022) 149 (20): dev200679.
Published: 14 September 2022
... oxygen tension) induces WNT pathway activity and is harnessed to enhance differentiation of embryonic stem cells into gastruloids. Hypoxia Hif1a WNT Gastruloid Pluripotency Max-Planck-Gesellschaft Bundesinstitut für Risikobewertung http://dx.doi.org/10.13039/501100008751...
Includes: Supplementary data
Journal Articles
Elena Melendez, Dafni Chondronasiou, Lluc Mosteiro, Jaime Martínez de Villarreal, Marcos Fernández-Alfara, Cian J. Lynch, Dirk Grimm, Francisco X. Real, José Alcamí, Núria Climent, Federico Pietrocola, Manuel Serrano
Journal:
Development
Development (2022) 149 (8): dev200361.
Published: 22 April 2022
... and MYC (OSKM) enables reprogramming of differentiated cells into pluripotent embryonic stem cells. Methods based on partial and reversible in vivo reprogramming are a promising strategy for tissue regeneration and rejuvenation. However, little is known about the barriers that impair reprogramming...
Includes: Supplementary data
Journal Articles
In collection:
Stem cells & regeneration
Masaki Kinoshita, Toshihiro Kobayashi, Benjamin Planells, Doris Klisch, Daniel Spindlow, Hideki Masaki, Susanne Bornelöv, Giuliano Giuseppe Stirparo, Hitomi Matsunari, Ayuko Uchikura, Ismael Lamas-Toranzo, Jennifer Nichols, Hiromitsu Nakauchi, Hiroshi Nagashima, Ramiro Alberio, Austin Smith
Journal:
Development
Development (2021) 148 (23): dev199901.
Published: 7 December 2021
... ABSTRACT Despite four decades of effort, robust propagation of pluripotent stem cells from livestock animals remains challenging. The requirements for self-renewal are unclear and the relationship of cultured stem cells to pluripotent cells resident in the embryo uncertain. Here, we avoided using feeder...
Includes: Supplementary data
Journal Articles
In collection:
Stem cells & regeneration
Journal:
Development
Development (2021) 148 (20): dev199909.
Published: 28 October 2021
... and function, microtubules have received less attention when unravelling the regulatory circuitry of pluripotency. Here, we summarise the role of microtubule organisation and microtubule-dependent events required for the formation of pluripotent cells in vivo by deciphering the process of early embryogenesis...
Journal Articles
In collection:
Stem cells & regeneration
Journal:
Development
Development (2021) 148 (17): dev199604.
Published: 10 September 2021
...Nicola Festuccia; Nick Owens; Almira Chervova; Agnès Dubois; Pablo Navarro ABSTRACT The maintenance of pluripotency in mouse embryonic stem cells (ESCs) is governed by the action of an interconnected network of transcription factors. Among them, only Oct4 and Sox2 have been shown to be strictly...
Includes: Supplementary data
Journal Articles
Journal:
Development
Development (2021) 148 (6): dev189217.
Published: 15 March 2021
... et al., 2011 , 2012 ) ( Fig. 2 A). Importantly, EpiLCs are considered equivalent to post-EPI cells in the E5.5 embryo, and are thought to represent a ‘formative state ’ of pluripotency ( Smith, 2017 ). In contrast, mouse ESCs cultured in 2i+LIF are equivalent to pre-EPI cells of the blastocyst...
Journal Articles
In collection:
Stem cells & regeneration
Journal:
Development
Development (2020) 147 (16): dev189845.
Published: 26 August 2020
..., they are referred to as pluripotent, rather than totipotent. Here, we consider the experimental potential of various ESC populations and a number of recently identified in vitro culture systems producing states beyond pluripotency and reminiscent of those observed during pre-implantation development. We also...
Includes: Supplementary data
Journal Articles
In collection:
Stem cells & regeneration
Journal:
Development
Development (2020) 147 (16): dev185264.
Published: 24 August 2020
...Zhenhua Zhu; Yan Zhang; Xiaoxiao Wang; Xiaohu Wang; Shou-Dong Ye ABSTRACT The identification of novel mechanisms to maintain embryonic stem cell (ESC) pluripotency is of crucial importance, because the currently used culture conditions are not suitable for ESCs from all species. In this study, we...
Includes: Supplementary data
Journal Articles
In collection:
Stem cells & regeneration
Sofiane Hamidi, Yukiko Nakaya, Hiroki Nagai, Cantas Alev, Takeya Kasukawa, Sapna Chhabra, Ruda Lee, Hitoshi Niwa, Aryeh Warmflash, Tatsuo Shibata, Guojun Sheng
Journal:
Development
Development (2020) 147 (3): dev184960.
Published: 3 February 2020
...Sofiane Hamidi; Yukiko Nakaya; Hiroki Nagai; Cantas Alev; Takeya Kasukawa; Sapna Chhabra; Ruda Lee; Hitoshi Niwa; Aryeh Warmflash; Tatsuo Shibata; Guojun Sheng ABSTRACT The pluripotent epiblast gives rise to all tissues and organs in the adult body. Its differentiation starts at gastrulation, when...
Includes: Supplementary data
Journal Articles
In collection:
Stem cells & regeneration
Journal:
Development
Development (2020) 147 (2): dev183129.
Published: 15 January 2020
... development and in embryonic stem cells by maintaining pluripotency or by regulating differentiation. In this Primer, we provide an updated overview of TET functions in development and stem cells. We discuss the catalytic and non-catalytic activities of TETs, and their roles as epigenetic regulators of both...
Journal Articles
In collection:
Chromatin & epigenetics
Journal:
Development
Development (2019) 146 (19): dev174516.
Published: 10 October 2019
.... , McManus , M. T. , Plath , K. , Meshorer , E. , et al. ( 2009 ). Chd1 regulates open chromatin and pluripotency of embryonic stem cells . Nature 460 , 863 - 868 . 10.1038/nature08212 Gaspar-Maia , A. , Alajem , A. , Meshorer , E. and Ramalho-Santos , M. ( 2011...
Includes: Supplementary data
Journal Articles
In collection:
Chromatin & epigenetics
Journal:
Development
Development (2019) 146 (19): dev164772.
Published: 25 September 2019
...Deniz Gökbuget; Robert Blelloch ABSTRACT Pluripotent stem cells give rise to all cells of the adult organism, making them an invaluable tool in regenerative medicine. In response to differentiation cues, they can activate markedly distinct lineage-specific gene networks while turning off...
Journal Articles
Alexander M. Tsankov, Marc H. Wadsworth, II, Veronika Akopian, Jocelyn Charlton, Samuel J. Allon, Aleksandra Arczewska, Benjamin E. Mead, Riley S. Drake, Zachary D. Smith, Tarjei S. Mikkelsen, Alex K. Shalek, Alexander Meissner
Journal:
Development
Development (2019) 146 (19): dev174722.
Published: 12 September 2019
...Alexander M. Tsankov; Marc H. Wadsworth, II; Veronika Akopian; Jocelyn Charlton; Samuel J. Allon; Aleksandra Arczewska; Benjamin E. Mead; Riley S. Drake; Zachary D. Smith; Tarjei S. Mikkelsen; Alex K. Shalek; Alexander Meissner ABSTRACT Maintenance of pluripotency and specification towards a new...
Includes: Supplementary data
Journal Articles
In collection:
Stem cells & regeneration
Journal:
Development
Development (2019) 146 (13): dev177220.
Published: 21 June 2019
... during their transition to primitive endoderm. He reported that, despite the transcriptional repression of certain pluripotency genes during differentiation, the TFs that regulate these genes remain stable at the protein level and can remain bound to their corresponding enhancers, thus rapidly...
Journal Articles
Elena Sena, Nathalie Rocques, Caroline Borday, Harem Sabr Muhamad Amin, Karine Parain, David Sitbon, Albert Chesneau, Béatrice C. Durand
Journal:
Development
Development (2019) 146 (10): dev173112.
Published: 22 May 2019
...://www.biologists.com/user-licence-1-1/ Summary: A novel nuclear inhibitor holds Tcf7l1 in a transcriptional inhibitory state and promotes silencing of Wnt target genes. Organizer Groucho/Tle Tcf/Lef Barhl2 Hdac Stem cells Wnt Pluripotency Transcription References Abramoff , M. D...
Includes: Supplementary data
Journal Articles
In collection:
Stem cells & regeneration
Journal:
Development
Development (2019) 146 (6): dev173146.
Published: 26 March 2019
..., gene regulation and network control of naive pluripotency, and the transition path from pluripotency to lineage commitment ( Blaschke et al., 2013 ; Carey et al., 2014 ; Dunn et al., 2014 ; Ficz et al., 2013 ; Habibi et al., 2013 ; Hackett et al., 2017 ; Hayashi et al., 2012 , 2011 ; Kalkan et...
Includes: Supplementary data
Journal Articles
Thorsten Boroviak, Giuliano G. Stirparo, Sabine Dietmann, Irene Hernando-Herraez, Hisham Mohammed, Wolf Reik, Austin Smith, Erika Sasaki, Jennifer Nichols, Paul Bertone
Journal:
Development
Development (2018) 145 (21): dev167833.
Published: 9 November 2018
... expression signatures are species, stage and lineage specific. The pluripotency network in the primate epiblast lacks certain regulators that are operative in mouse, but encompasses WNT components and genes associated with trophoblast specification. Sequential activation of GATA6, SOX17 and GATA4 markers...
Includes: Supplementary data
Journal Articles
Journal:
Development
Development (2018) 145 (15): dev163386.
Published: 8 August 2018
... for HDAC activity initiates in naïve blastula cells; HDAC inhibition causes loss of pluripotency gene expression and blocks the ability of blastula stem cells to contribute to lineages of the three embryonic germ layers. We find that pluripotent naïve blastula cells and neural crest cells are both...
Includes: Supplementary data
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