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Keywords: Pluripotency
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Journal Articles
Journal Articles
Journal: Development
Development (2022) 149 (24): dev200988.
Published: 21 December 2022
...Anish Dattani; Tao Huang; Corin Liddle; Austin Smith; Ge Guo ABSTRACT Propagation of human naïve pluripotent stem cells (nPSCs) relies on the inhibition of MEK/ERK signalling. However, MEK/ERK inhibition also promotes differentiation into trophectoderm (TE). Therefore, robust self-renewal requires...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2022) 149 (8): dev200361.
Published: 22 April 2022
... and MYC (OSKM) enables reprogramming of differentiated cells into pluripotent embryonic stem cells. Methods based on partial and reversible in vivo reprogramming are a promising strategy for tissue regeneration and rejuvenation. However, little is known about the barriers that impair reprogramming...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2021) 148 (20): dev199909.
Published: 28 October 2021
... and function, microtubules have received less attention when unravelling the regulatory circuitry of pluripotency. Here, we summarise the role of microtubule organisation and microtubule-dependent events required for the formation of pluripotent cells in vivo by deciphering the process of early embryogenesis...
Journal Articles
Journal: Development
Development (2021) 148 (17): dev199604.
Published: 10 September 2021
...Nicola Festuccia; Nick Owens; Almira Chervova; Agnès Dubois; Pablo Navarro ABSTRACT The maintenance of pluripotency in mouse embryonic stem cells (ESCs) is governed by the action of an interconnected network of transcription factors. Among them, only Oct4 and Sox2 have been shown to be strictly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (6): dev189217.
Published: 15 March 2021
... et al., 2011 , 2012 ) ( Fig. 2 A). Importantly, EpiLCs are considered equivalent to post-EPI cells in the E5.5 embryo, and are thought to represent a ‘formative state ’ of pluripotency ( Smith, 2017 ). In contrast, mouse ESCs cultured in 2i+LIF are equivalent to pre-EPI cells of the blastocyst...
Journal Articles
Journal: Development
Development (2020) 147 (16): dev189845.
Published: 26 August 2020
..., they are referred to as pluripotent, rather than totipotent. Here, we consider the experimental potential of various ESC populations and a number of recently identified in vitro culture systems producing states beyond pluripotency and reminiscent of those observed during pre-implantation development. We also...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (16): dev185264.
Published: 24 August 2020
...Zhenhua Zhu; Yan Zhang; Xiaoxiao Wang; Xiaohu Wang; Shou-Dong Ye ABSTRACT The identification of novel mechanisms to maintain embryonic stem cell (ESC) pluripotency is of crucial importance, because the currently used culture conditions are not suitable for ESCs from all species. In this study, we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (3): dev184960.
Published: 3 February 2020
...Sofiane Hamidi; Yukiko Nakaya; Hiroki Nagai; Cantas Alev; Takeya Kasukawa; Sapna Chhabra; Ruda Lee; Hitoshi Niwa; Aryeh Warmflash; Tatsuo Shibata; Guojun Sheng ABSTRACT The pluripotent epiblast gives rise to all tissues and organs in the adult body. Its differentiation starts at gastrulation, when...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (2): dev183129.
Published: 15 January 2020
... development and in embryonic stem cells by maintaining pluripotency or by regulating differentiation. In this Primer, we provide an updated overview of TET functions in development and stem cells. We discuss the catalytic and non-catalytic activities of TETs, and their roles as epigenetic regulators of both...
Journal Articles
Journal: Development
Development (2019) 146 (19): dev174516.
Published: 10 October 2019
.... , McManus , M. T. , Plath , K. , Meshorer , E. , et al. ( 2009 ). Chd1 regulates open chromatin and pluripotency of embryonic stem cells . Nature   460 , 863 - 868 . 10.1038/nature08212 Gaspar-Maia , A. , Alajem , A. , Meshorer , E. and Ramalho-Santos , M. ( 2011...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (19): dev164772.
Published: 25 September 2019
...Deniz Gökbuget; Robert Blelloch ABSTRACT Pluripotent stem cells give rise to all cells of the adult organism, making them an invaluable tool in regenerative medicine. In response to differentiation cues, they can activate markedly distinct lineage-specific gene networks while turning off...
Journal Articles
Journal Articles
Journal: Development
Development (2019) 146 (13): dev177220.
Published: 21 June 2019
... during their transition to primitive endoderm. He reported that, despite the transcriptional repression of certain pluripotency genes during differentiation, the TFs that regulate these genes remain stable at the protein level and can remain bound to their corresponding enhancers, thus rapidly...
Journal Articles
Journal Articles
Journal: Development
Development (2019) 146 (6): dev173146.
Published: 26 March 2019
...-plated before initiating differentiation, there will be more proliferation before exiting pluripotency. Cell density can be lowered to 0.8×10 4 cells/cm 2 . The efficiency and timing of differentiation can be assessed by using the Sox1GFP reporter cell line ( Ying et al., 2003b ) or by measuring...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2018) 145 (15): dev163386.
Published: 8 August 2018
... for HDAC activity initiates in naïve blastula cells; HDAC inhibition causes loss of pluripotency gene expression and blocks the ability of blastula stem cells to contribute to lineages of the three embryonic germ layers. We find that pluripotent naïve blastula cells and neural crest cells are both...
Includes: Supplementary data