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Keywords: Planarian
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Journal Articles
Journal: Development
Development (2022) 149 (7): dev200125.
Published: 30 March 2022
...Nicolle A. Bonar; David I. Gittin; Christian P. Petersen ABSTRACT Tissue identity determination is crucial for regeneration, and the planarian anteroposterior (AP) axis uses positional control genes expressed from body wall muscle to determine body regionalization. Canonical Wnt signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (15): dev196097.
Published: 2 August 2021
...Stephanie H. Nowotarski; Erin L. Davies; Sofia M. C. Robb; Eric J. Ross; Nicolas Matentzoglu; Viraj Doddihal; Mol Mir; Melainia McClain; Alejandro Sánchez Alvarado ABSTRACT As the planarian research community expands, the need for an interoperable data organization framework for tool building has...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (24): 4540–4551.
Published: 15 December 2017
..., freshwater planarian Schmidtea mediterranea . Using an RNA-sequencing approach, we identified two classes of markers expressed in sequential fashion when new pigment cells are generated during regeneration or in response to pigment cell ablation. We also report roles for FOXF-1 and ETS-1 transcription...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (19): 3440–3453.
Published: 1 October 2017
... to follow stem cell migration in planarians. We demonstrate the use of this system to study the molecular control of stem cell migration and show that snail-1 , snail-2 and zeb-1 EMT transcription factor homologs are necessary for cell migration to wound sites and for the establishment of migratory cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (18): 3211–3223.
Published: 15 September 2017
...Vidyanand Sasidharan; Srujan Marepally; Sarah A. Elliott; Srishti Baid; Vairavan Lakshmanan; Nishtha Nayyar; Dhiru Bansal; Alejandro Sánchez Alvarado; Praveen Kumar Vemula; Dasaradhi Palakodeti Brain regeneration in planarians is mediated by precise spatiotemporal control of gene expression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (12): 2089–2102.
Published: 15 June 2016
...Sara Barberán; Susanna Fraguas; Francesc Cebrià The planarian Schmidtea mediterranea maintains and regenerates all its adult tissues through the proliferation and differentiation of a single population of pluripotent adult stem cells (ASCs) called neoblasts. Despite recent advances, the mechanisms...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (10): 1697–1709.
Published: 15 May 2016
... in posterior regions of adult animals. However, the molecular underpinnings of these regional differences are unknown. We identified a regional switch in the adult planarian body upon systemic disruption of homologous recombination with RNA-interference of Rad51 . Rad51 knockdown increases DNA double-strand...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (14): 2413–2424.
Published: 15 July 2015
... roles in regeneration, and further study of conserved signalling pathways is required. Here we have studied the role of the conserved JNK signalling cascade during planarian regeneration. Abrogation of JNK signalling by RNAi or pharmacological inhibition blocks posterior regeneration and animals fail...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (9): 1835–1847.
Published: 1 May 2014
...Susanna Fraguas; Sara Barberán; Marta Iglesias; Gustavo Rodríguez-Esteban; Francesc Cebrià During the regeneration of freshwater planarians, polarity and patterning programs play essential roles in determining whether a head or a tail regenerates at anterior or posterior-facing wounds...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (17): 3577–3588.
Published: 1 September 2013
...Ko W. Currie; Bret J. Pearson In contrast to most adult organisms, freshwater planarians can regenerate any injured body part, including their entire nervous system. This allows for the analysis of genes required for both the maintenance and regeneration of specific neural subtypes. In addition...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (5): 951–957.
Published: 1 March 2013
...Peter W. Reddien Planarians are flatworms capable of regenerating all body parts. Planarian regeneration requires neoblasts, a population of dividing cells that has been studied for over a century. Neoblast progeny generate new cells of blastemas, which are the regenerative outgrowths at wounds...
Journal Articles
Journal: Development
Development (2013) 140 (4): 730–739.
Published: 15 February 2013
... lineages. Of particular importance will be understanding the architecture of regenerative genetic regulatory networks and whether they are conserved across broad phylogenetic distances. Here, we describe the role of the conserved TALE class protein PBX/Extradenticle in planarians, a representative member...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (6): 1083–1094.
Published: 15 March 2012
...Labib Rouhana; Ana P. Vieira; Rachel H. Roberts-Galbraith; Phillip A. Newmark Planarian flatworms contain a population of adult stem cells (neoblasts) that proliferate and generate cells of all tissues during growth, regeneration and tissue homeostasis. A characteristic feature of neoblasts...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (20): 4387–4398.
Published: 15 October 2011
...M. Lucila Scimone; Mansi Srivastava; George W. Bell; Peter W. Reddien Planarians can regenerate any missing body part, requiring mechanisms for the production of organ systems in the adult, including their prominent tubule-based filtration excretory system called protonephridia. Here, we identify...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (17): 3679–3688.
Published: 1 September 2011
...Tetsutaro Hayashi; Minako Motoishi; Shigenobu Yazawa; Kazu Itomi; Chiharu Tanegashima; Osamu Nishimura; Kiyokazu Agata; Hiroshi Tarui Planarians have high regenerative ability, which is dependent on pluripotent adult somatic stem cells called neoblasts. Recently, canonical Wnt/β-catenin signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (12): 2417–2427.
Published: 15 June 2011
...Junichi Tasaki; Norito Shibata; Osamu Nishimura; Kazu Itomi; Yoshimichi Tabata; Fuyan Son; Nobuko Suzuki; Ryoko Araki; Masumi Abe; Kiyokazu Agata; Yoshihiko Umesono The robust regenerative ability of planarians depends on a population of somatic stem cells called neoblasts, which are the only...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (17): 3121–3131.
Published: 1 September 2007
...) of the planarian Schmidtea mediterranea. smedinx-11 RNAi treatment inhibits regeneration and abrogates neoblast maintenance. Moreover, smedinx-11 expression is enriched in an irradiation-sensitive subpopulation (`X2') and is required for proper expression of other stem cell-specific markers. Analyses...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (9): 1679–1689.
Published: 1 May 2007
...Takeshi Inoue; Tetsutaro Hayashi; Katsuaki Takechi; Kiyokazu Agata Planarians have a well-organized central nervous system (CNS), including a brain, and can regenerate the CNS from almost any portion of the body using pluripotent stem cells. In this study, to identify genes required for CNS...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (5): 833–837.
Published: 1 March 2007
... in the planarian Schmidtea mediterranea . RNA interference (RNAi) knockdown of a planarian ortholog of the axon-guidance receptor roundabout ( robo ) leads to unexpected phenotypes during anterior regeneration, including the development of a supernumerary pharynx (the feeding organ of the animal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (16): 3691–3703.
Published: 15 August 2005
...Francesc Cebrià; Phillip A. Newmark Conserved axon guidance mechanisms are essential for proper wiring of the nervous system during embryogenesis; however, the functions of these cues in adults and during regeneration remain poorly understood. Because freshwater planarians can regenerate...
Includes: Supplementary data