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Keywords: Planar cell polarity
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Journal Articles
Journal: Development
Development (2022) 149 (9): dev200315.
Published: 6 May 2022
... Antic , D. , Stubbs , J. L. , Suyama , K. , Kintner , C. , Scott , M. P. and Axelrod , J. D. ( 2010 ). Planar cell polarity enables posterior localization of nodal cilia and left-right axis determination during mouse and Xenopus embryogenesis . PLoS ONE 5 , e8999...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (18): dev199695.
Published: 23 September 2021
... of epithelia known as planar cell polarity (PCP). This property is controlled by the core PCP pathway, which consists of highly conserved membrane-associated protein complexes that localize asymmetrically at cell junctions. Here, we introduce three new mouse models for investigating the localization...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (14): dev199421.
Published: 12 July 2021
...Anurag Kakkerla Balaraju; Bo Hu; Juan J. Rodriguez; Matthew Murry; Fang Lin ABSTRACT Noncanonical Wnt/planar cell polarity (Wnt/PCP) signaling has been implicated in endoderm morphogenesis. However, the underlying cellular and molecular mechanisms of this process are unclear. We found that, during...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (13): dev196386.
Published: 8 July 2021
...Antoine Donati; Isabelle Anselme; Sylvie Schneider-Maunoury; Christine Vesque ABSTRACT Epithelial cilia, whether motile or primary, often display an off-center planar localization within the apical cell surface. This form of planar cell polarity (PCP) involves the asymmetric positioning...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (23): dev193425.
Published: 11 December 2020
...Krishnanand Padmanabhan; Hanna Grobe; Jonathan Cohen; Arad Soffer; Adnan Mahly; Orit Adir; Ronen Zaidel-Bar; Chen Luxenburg ABSTRACT Planar cell polarity (PCP) is essential for tissue morphogenesis and homeostasis; however, the mechanisms that orchestrate the cell shape and packing dynamics...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev191726.
Published: 30 November 2020
... and lateral nasal processes. We demonstrate that Prickle1 , a key component of planar cell polarity signaling, is expressed in progenitors of the PTD and throughout tear duct morphogenesis. Disruption of Prickle1 stalls tear duct elongation; in particular, the loss of basement membrane deposition and aberrant...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev192724.
Published: 18 November 2020
... and vascular development in mouse embryos lacking fibronectin . Development   119 , 1079 - 1091 . Goto , T. , Davidson , L. , Asashima , M. and Keller , R. ( 2005 ). Planar cell polarity genes regulate polarized extracellular matrix deposition during frog gastrulation . Curr. Biol...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (7): dev186957.
Published: 8 April 2020
... fibers during tissue elongation in the Drosophila ovarian follicle and two new developmental functions for the Dystrophin-Dystroglycan complex. Morphogenesis Extracellular matrix Drosophila Tissue elongation Planar cell polarity Dystrophin Dystroglycan Basement membrane...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev181719.
Published: 9 October 2019
... to preferentially elongate anteroposteriorly. Loss of Wnt5, a putative ligand of the planar cell polarity (PCP) pathway, causes the SpM-SHF to expand isotropically. Temporal tracking reveals that the Wnt5a lineage is a unique subpopulation specified as early as E7.5, and undergoes bi-directional deployment to form...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2019) 146 (17): dev179275.
Published: 2 September 2019
... show that Combover (Cmb), originally identified as an effector of planar cell polarity (PCP) under control of Rho kinase, is essential for sperm individualization. cmb mutants are male sterile, with actin cones that fail to move in a synchronized manner along the flagella, despite being correctly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (9): dev161885.
Published: 10 May 2019
..., and disruption of planar spindle orientation has detrimental consequences for epidermal architecture. Defects in planar cell polarity (PCP) can disrupt spindle positioning during tissue morphogenesis. Upon Arl3 loss, the PCP signaling molecules Celsr1 and Vangl2 failed to maintain planar polarized distributions...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev169326.
Published: 3 December 2018
...Sergio Garrido-Jimenez; Angel-Carlos Roman; Alberto Alvarez-Barrientos; Jose Maria Carvajal-Gonzalez ABSTRACT In vertebrates, planar polarization of ciliary basal bodies has been associated with actin polymerization that occurs downstream of the Frizzled-planar cell polarity (Fz-PCP) pathway...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (19): dev168468.
Published: 8 October 2018
...Bo Dong; Samantha Vold; Cristina Olvera-Jaramillo; Hao Chang ABSTRACT The orientation of mouse hair follicles is controlled by the planar cell polarity (PCP) pathway. Mutations in PCP genes result in two categories of hair mis-orientation phenotype: randomly oriented and vertically oriented...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (18): dev168112.
Published: 17 September 2018
...José Casal; Beatriz Ibáñez-Jiménez; Peter A. Lawrence ABSTRACT Epithelial cells are polarised within the plane of the epithelium, forming oriented structures that have a coordinated and consistent polarity (planar cell polarity, PCP). In Drosophila , at least two separate molecular systems generate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (17): dev162792.
Published: 14 September 2018
... unclear how the keratinocytes sense this gradient and orient barb growth. Here, we show that in chicken, owing to feather branching, the global Wnt gradient is subdivided into periodic barbs. Within each barb, the anterior barbule plate cells tilt before the posterior cells. The core planar cell polarity...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2018) 145 (12): dev159012.
Published: 14 June 2018
... providing neuroprotection in extreme noise. Type II neurons make a distinctive 90° turn towards the cochlear base to synapse with 10-15 outer hair cells. We demonstrate that this axon turning event requires planar cell polarity (PCP) signaling and is disrupted in Vangl2 and Celsr1 knockout mice...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (8): dev163824.
Published: 13 April 2018
...Bo Gao; Rieko Ajima; Wei Yang; Chunyu Li; Hai Song; Matthew J. Anderson; Robert R. Liu; Mark B. Lewandoski; Terry P. Yamaguchi; Yingzi Yang ABSTRACT Embryonic morphogenesis of a complex organism requires proper regulation of patterning and directional growth. Planar cell polarity (PCP) signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (21): 3978–3989.
Published: 1 November 2017
... radially with an apically directed slant – a feature considered crucial for hearing. To determine how this pattern is generated, collagen-fibril formation was examined in mice lacking a tectorin-based matrix, epithelial cilia or the planar cell polarity genes Vangl2 and Ptk7 . In wild-type mice, collagen...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (9): 1712–1724.
Published: 1 May 2017
... clustering downstream of activation of the β-catenin pathway. Strikingly, Wnt4 and Wnt11 co-immunoprecipitate with Vangl2, a core component of the planar cell polarity (PCP) pathway, which accumulates at embryonic NMJs. Moreover, mice bearing a Vangl2 loss-of-function mutation (loop-tail) exhibit fewer AChR...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2017) 144 (4): 552–566.
Published: 15 February 2017
.... , Zhao , Q. , Rank , G. , Auden , A. , Srivastava , S. , Papenfuss , T. A.   et al. ( 2010 ). Epidermal wound repair is regulated by the planar cell polarity signaling pathway . Dev. Cell   19 , 138 - 147 . 10.1016/j.devcel.2010.06.008 Camerer , E. , Barker...