...-associated proteolytic pathway that regulates epithelial development in mouse, independent of its own proteolytic activity. Cell surface proteolysis Serine protease Epithelial development Placental labyrinth Trypsin-like serine proteases are a large family of proteolytic enzymes that reside...

... Spint2 gene led to defects in neural tube closure, abnormal placental labyrinth development associated with loss of epithelial cell polarity, and embryonic demise. Developmental defects observed in HAI2-deficient mice were caused by unregulated matriptase activity, as both placental development...